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Lupus can affect the scalp and nails, often causing hair loss and nail damage, and needs early aggressive treatment to prevent permanent damage.

The Brazilian Society of Dermatology agrees that oral isotretinoin is effective for acne and other skin conditions, and it's safe when monitored, but more research is needed on dosing and duration.

Some cases of tinea capitis, a fungal scalp infection, can look like scarring hair loss due to the body's immune response and the fungus itself.

The document says that treating the root cause of hair follicle damage is crucial to prevent permanent hair loss, and treatment options vary.

The NUDT15 gene variant causes severe side effects from azathioprine in some Indian patients.

A specific gene variant is linked to a higher risk of hair loss from chemotherapy in breast cancer patients.

Nirmatrelvir/Ritonavir treatment may lead to a weaker immune response to COVID-19, but doesn't affect the chance of rebound.

Higher testosterone levels can increase the risk of certain diseases like type 2 diabetes in women and prostate cancer in men, but can also protect against autoimmune diseases and hair loss. It also affects body fat and bone density.

Certain variations of the HDAC9 gene can increase or decrease stroke risk in the Chinese population.

People with Down syndrome have a higher risk of skin disorders and need better screening and treatment.

Segmental Vitiligo is a stable, early-onset form of vitiligo that responds well to early treatment and is ideal for repigmentation studies.

The document concludes that permanent hair loss conditions are complex, require early specific treatments, and "secondary permanent alopecias" might be a more accurate term than "secondary cicatricial alopecia."

Alopecia areata and vitiligo can coexist, respond well to treatment, and may have a better prognosis together.

Men with early balding should be checked for metabolic syndrome, as there's a link between the two.

Acne is a chronic skin condition not caused by poor hygiene or diet, and it requires long-term treatment and patient education.

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

Acne is significantly influenced by genetics, and understanding its genetic basis could lead to better, targeted treatments.

Different ACE2 gene versions may affect COVID-19 impact based on age and suggest some hair loss drugs could be potential treatments.

JAK inhibitors show promise for treating skin conditions like eczema, hair loss, and psoriasis.

People on immune-modifying skin disease treatments may have a weaker antibody response to COVID-19 vaccines but often improve after the second dose.

Hormonal treatments can help with hair loss, acne, and excess hair growth, but it takes 3-6 months to see results and patients should know the possible side effects.

The document concluded that stem cells are crucial for skin repair, regeneration, and may help in developing advanced skin substitutes.

Researchers found that certain RNA circles in the brain are linked to disease risk, but their exact role in disease is still unknown.

Intermediate filaments are crucial for cell differentiation and stem cell function.

Long-term high testosterone levels can improve bone density and reduce body fat but may increase the risk of prostate cancer and high blood pressure.

Increased free testosterone can lead to stronger bones and less body fat but also higher risks of prostate cancer, hair loss, spine issues, and high blood pressure.

Maintaining DNA health in stem cells is key to preventing aging and tissue breakdown.

Keratins help protect cells, aid in cancer diagnosis, and influence cancer behavior and treatment.

Skin reactions are a common reason for emergency visits due to drug allergies, with some severe cases needing intensive care.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.