January 2014 in “Springer eBooks” Inflammasome proteins can indicate the severity and treatment response of various diseases and injuries.
March 2013 in “Actas Dermo-Sifiliográficas” This review discusses recent advancements in dermatopathology, including molecular biology techniques and diagnostic innovations, and reports no new experimental findings.
This review describes the link between obesity and gastrointestinal conditions, highlighting the need for more research to understand their pathophysiology and develop new treatments; it presents no new findings.
March 2006 in “Drug Discovery Today: Therapeutic Strategies” The 2006 editorial concluded that immunotherapy was advancing with new drugs, focusing on specific biological therapies and convenient oral treatments, and highlighted the importance of partnerships and new regulations in the field.
September 2025 in “Cuadernos de Educación y Desarrollo” This study reviewed the literature on laser and light technologies in dermatology, highlighting their varied clinical applications such as skin rejuvenation, acne scar treatment, and hair removal, alongside their potential for combining with AI to improve outcomes.
This review discusses the effectiveness of adipose-derived stem cells in treating alopecia, reporting on various clinical studies but presenting no new clinical results.
32 citations
,
March 2014 in “PLOS ONE” This study demonstrates that FMOD deficiency in mice alters TGF-β ligand and receptor expression during wound healing stages, leading to delayed wound closure and increased scar size.
42 citations
,
September 2012 in “PLoS ONE” In this study, bezafibrate treatment improved certain aging-like features in a mouse model with mitochondrial dysfunction, but did not enhance muscle function or lifespan.
175 citations
,
December 2014 in “PLoS Biology” This study found that macrophages near hair follicles contribute to the activation of skin epithelial stem cells in mice, suggesting a novel role for macrophages in regulating hair growth.
127 citations
,
January 2013 in “PLOS ONE” This study found that feeding aged mice a probiotic yogurt induced changes leading to thicker, healthier fur, suggesting a bacteria-triggered interleukin-10-dependent mechanism that mimics signs of youth and reproductive fitness.
82 citations
,
May 2010 in “PLoS neglected tropical diseases” This study provides quantitative evidence that secondary syphilis is highly endemic in Cali, Colombia, and many untreated patients have high numbers of circulating Treponema pallidum spirochetes.
24 citations
,
November 2021 in “PLoS ONE” In this study, fractional laser treatment was observed to reverse age-related gene expression changes in skin and enhance dermal remodeling, further improved by multiple treatments.
November 2025 in “PLoS ONE” This study found that synthetic RNA and DNA trigger significant increases in certain chemokines in human keratinocytes, predominantly via NF-κB activation, without evidence of alternative splicing, suggesting other regulatory pathways may be involved.
February 2026 in “Frontiers in Materials” In this study, researchers developed iron-curcumin-coordinated nanoparticles to enhance curcumin's bioavailability and therapeutic effects, finding that these nanoparticles accelerate wound healing in diabetic mice by reducing inflammation and oxidative stress more effectively than free curcumin.
January 2026 in “Frontiers in Medicine” This article questions whether frontal fibrosing alopecia and fibrosing androgeneic patterned hair loss are overlapping conditions or stages of the same process, calling for further research to clarify their underlying factors.
January 2026 in “Frontiers in Pharmacology” This study suggests that cedrol may improve mitochondrial function, gut microbiota, and intestinal barrier integrity, indicating its potential value in treating inflammatory bowel disease.
March 2026 in “Frontiers in Medicine” This study reviews advances in targeted therapies for moderate-severe dermatological conditions like plaque psoriasis and atopic dermatitis, reporting on newly approved treatments and highlighting the need for further innovations in managing rare inflammatory skin diseases through emerging laboratory techniques and trials.
18 citations
,
March 2024 in “Frontiers in Pharmacology” This review highlights that the NLRP3 inflammasome is a promising therapeutic target for cerebral ischemia-reperfusion injury and discusses recent advancements in using natural plant products to modulate this pathway and reduce inflammation.
1 citations
,
May 2025 in “Frontiers in Medicine” In this case series, dual-targeted therapy was observed to provide promising clinical responses in refractory inflammatory bowel disease, with 88.23% to 100% response rates across 9 months and an endoscopic response in 88.89% of evaluated patients, though some adverse events occurred.
December 2025 in “Frontiers in Endocrinology” This study found that elevated CgA levels in PCOS are associated with obesity, insulin resistance, and low-grade inflammation, suggesting CgA may be a novel biomarker for metabolic risk stratification in PCOS.
8 citations
,
March 2020 in “Dermatologic Therapy” This study found that a new formulation kit of Pielus Anti-hair loss lotion and shampoo, used daily for 90 days, was safe and effective in reducing hair loss and increasing hair strength and density among patients with telogen effluvium and/or androgenetic alopecia.
1 citations
,
February 2021 in “Gastroenterology” This report discusses a case of vesiculopustular eruption in a patient with ulcerative colitis, highlighting the effective use of ustekinumab for treatment and suggesting its consideration in similar cases of IBD-related skin lesions.
March 2018 in “Suez Canal University Medical Journal” This review examines targeting the JAK-STAT pathway in inflammatory skin diseases, highlighting existing JAK inhibitors and potential developments, but presents no new experimental or clinical results.
51 citations
,
October 1981 in “British Journal of Dermatology” This study found that in patients who underwent jejuno-ileal bypass for morbid obesity, dapsone was effective in treating inflammatory skin lesions and joint symptoms when other antibiotics failed.
47 citations
,
June 2012 in “Genes & Development” This study found that maternal consumption of a western diet in mice led to toxic milk production, causing inflammation and alopecia in nursing neonates due to Toll-like-receptor activation.
42 citations
,
September 2018 in “Journal der Deutschen Dermatologischen Gesellschaft” This review discusses the distinct clinical and psychological aspects of adult female acne and reports no new clinical results, highlighting the need for a comprehensive management approach.
32 citations
,
December 2009 in “Archives of Dermatological Research” In this study, DHT was associated with increased production of proinflammatory cytokines IL-6 and TNF-α in cultured sebocytes, suggesting a role in acne pathophysiology beyond sebum production.
29 citations
,
June 2018 in “Scientific Reports” In this study, Alox15 knockout mice exhibited disrupted skin integrity and increased inflammation, suggesting that Alox15-mediated resolvin D2 production is crucial for maintaining skin homeostasis by suppressing inflammation.
24 citations
,
January 2012 in “Indian Journal of Dermatology, Venereology and Leprology” This study suggests that hypersensitivity and increased serum IgE levels might contribute to the pathogenesis of diffuse alopecia areata through intense local inflammatory infiltration.
15 citations
,
July 2019 in “Journal of Investigative Dermatology” This exploratory study found that cannabidiol (CBD) at higher concentrations may inhibit hair growth by promoting the onset of catagen in human hair follicles, while lower concentrations showed potential anti-inflammatory effects without promoting catagen.