Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that hairless mice with homozygous mutations developed significantly more aggressive basal cell carcinomas and a heightened inflammatory response to UVB exposure compared to their haired littermates.

This study found that 650-nm red light treatment promoted hair follicle proliferation and delayed the transition from anagen to catagen in ex vivo hair follicles from androgenetic alopecia patients, with RNA-seq analysis suggesting involvement of biological processes like metabolism and leukocyte migration.

This article is a letter to the editor discussing potential therapeutic synergy between a wig-fixing device and tofacitinib for treating alopecia areata but reports no new clinical results.

This study found a significant overlap between gene expression signatures of alopecia areata and certain chronic inflammatory skin disorders, suggesting shared biological processes may drive their co-occurrence and providing a foundation for future research into distinct comorbid subtypes.

This study develops FR-1, a topical small molecule, which reduces scarring and avoids skin atrophy in a murine wound model, showing potential for treating fibrosis without the side effects of current therapies.

This study found that MEG3-miRNAs are key regulators of the age-dependent crimped wool trait in Tan sheep, likely influencing primary follicle development and degeneration through immune-inflammatory pathways.

This study identified 193 plasma proteins associated with prostate cancer risk, validating 20 high-risk proteins including KLK3, and pinpointed potential drug targets like HSPB1, RRM2B, and PSCA through genetic analysis, offering new insights for biomarkers and treatments.

This study demonstrated that in mice, the absence of Jagged-1 expression in skin-resident regulatory T cells significantly delays wound healing by reducing the accumulation of neutrophils, highlighting the role of Jagged-1 in coordinating immune cell recruitment during injury.

This study found that N,N-dimethylglycine sodium salt promoted proliferation and migration of cultured human epidermal keratinocytes and had anti-inflammatory and antioxidant effects in vitro.

This study found that conditional deletion of Mof in mice resulted in severe defects in skin development, including compromised epidermal differentiation and hair growth, leading to perinatal lethality.

In this study, researchers found that alopecia areata patients show a significant reduction in suppressive regulatory T-cells and an increase in inflammatory T-cell populations, suggesting an immunological imbalance contributing to the disease.

This study identified two distinct fibroblast subsets in mouse skin, revealing that adult skin scarring occurs due to the repair process utilizing only one, lineage-restricted fibroblast type instead of coordinated diverse populations.

Proteins like aPKC and PDGF-AA, substances like adenosine and ATP, and adipose-derived stem cells all play important roles in hair growth and health, and could potentially be used to treat hair loss and skin conditions.

This review discusses the potential dermatological applications of Dendrobium officinale polysaccharides, noting their hair growth promoting, skin moisturizing, and antioxidant effects, but reports no new clinical results.

This study identified transcription elongation as a crucial regulatory factor in adipocyte cell fate, showing that the elongation factors Spt4 and Spt6 are essential for proper adipogenic differentiation by aiding RNA polymerase II progression through key adipogenic genes.

This review examines apoptotic and anti-apoptotic mechanisms in skin homeostasis and related diseases but presents no new research findings.

This review summarizes existing knowledge of how the WNT signaling pathway affects mesenchymal stem cells under various conditions, highlighting challenges and mechanisms for clinical applications.

This review discusses the protective roles of skin-resident immune cells in maintaining tissue homeostasis and facilitating wound healing, but reports no new experimental findings.

This article reviews the epidemiology, clinical evaluation, and pathogenesis of alopecia areata and highlights recent advancements, but it does not report new clinical findings.

This review discusses the role of regulatory T-cells in tissue repair and regeneration across various organs and reports no new clinical results.

This review discusses the potential role of oxidative stress in hair graying and age-related alopecia, emphasizing the need for new strategies to counteract these effects, but reports no new results.

This study found that in mice, dermal adipocytes initiate inflammation and aid repair after skin injury by releasing lipids, suggesting a role in managing inflammatory diseases and impaired wound healing.

This review discusses the effects of estrogens on skin aging and highlights the potential benefits of estrogen replacement therapy and selective estrogen receptor modulators for improving skin health in postmenopausal women, but reports no new clinical findings.

This study found that adipose-derived mesenchymal stromal cell secretome, particularly when preconditioned with IFNγ, significantly influences cell motility and anti-inflammatory responses, enhancing its potential as a regenerative therapy.

This review discusses the impact of sleep cycles and circadian rhythms on nighttime exacerbation of atopic dermatitis in children and presents potential treatment options for related sleep disturbances, but reports no new clinical results.

This review discusses the potential of ultraviolet (UV) radiation technologies in wound care, highlighting their antimicrobial properties and risks of DNA damage, but reports no new clinical findings.

This review examines dandruff and seborrheic dermatitis, highlighting the role of Malassezia yeasts in inflammation and hyper-proliferation, and reports no new clinical findings.

This review discusses the role of tyrosine kinase signaling pathways in autoimmune and inflammatory skin diseases and reports no new clinical results, highlighting ongoing research into small-molecule tyrosine kinase inhibitors as potential treatments.

This review summarizes 15 years of clinical and experimental research advancements in hidradenitis suppurativa, highlighting its recognition as a uniquely healable inflammatory skin disease but reports no new clinical results.

This research abstract provides no results, focusing on the equal contributions of the authors in the field of molecular, cellular, and developmental biology from Yale University.