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This study shows that alpha 6 + /MHCI - cells have gene expression profiles similar to hair follicle stem cells, suggesting they may be enriched for stem cells.

This study found that both ethanol and aqueous extracts of Lepidium sativum seeds improved insulin signaling and reduced obesity-related metabolic changes in high-fat diet-fed rats, suggesting potential as a dietary supplement.

This study reported that pathways related to apoptosis, cell proliferation, and WNT signaling might be key drivers of hair loss in androgenetic alopecia, guiding potential targets for therapy development.

This study examined noninvasive tissue samples, including buccal swabs, hair follicles, saliva, and urine cell pellets, and found hair follicles and urine cell pellets promising for transcriptomic and clinical analyses due to their sample quality and performance in disease-relevant applications.

In this study, a mixture of tocopherol acetate, L-menthol, and stevioside was more effective in promoting hair growth in mice compared to tocopherol acetate or L-menthol alone.

This study mapped gene expression in different skin structures of dogs, finding similarities to humans that support using dogs as models for human skin diseases.

This study found that alopecia areata patients had significantly higher levels of interleukin-6 compared to healthy controls.

This study found that 3D-cultured dermal papilla cells more accurately mimic in vivo conditions compared to 2D cultures, enhancing our understanding of molecular mechanisms in androgen-induced alopecia.

This article reviews the role of KLF4, a transcription factor, in various cellular processes and its dual function as a tumor suppressor or oncogene depending on the context, but presents no new experimental results.

This article reviews the botanical characteristics, traditional and modern medicinal uses, and market potential of Prunus mira, but reports no new clinical findings.

This study found that a mixture of plant extracts significantly improved skin barrier function, reduced inflammation, and exhibited anti-aging effects in human skin cells.

This research detailed a single-cell atlas showing dynamic hair follicle stem cell states associated with the hair cycle during aging in mice, highlighting differences in chromatin landscape linked to stem cell differentiation and quiescence, and providing a foundation for future exploration of aging reversal.

This study created a detailed spatial atlas of healthy human skin and basal cell carcinoma, revealing a potential hair follicle origin for basal cell carcinoma and expansion of certain mesenchymal cell populations.

This study reported that alopecia in giant pandas may be linked to abnormal expression of several hair-related genes and pathways, providing insight for potential prevention and treatment strategies.

This study concluded that the CXCL12–CXCR4 signaling pathway significantly contributes to hair loss in androgenetic alopecia and alopecia areata by promoting inflammation and fibrosis, whereas inhibiting this pathway can restore hair growth and follicle health.

This review discusses the multifaceted roles of regulatory T cells in cutaneous wound healing and highlights potential therapeutic strategies targeting these cells to enhance wound repair in chronic and diabetic wounds, but reports no new clinical results.

This study demonstrated that skin organoids derived from human stem cells can model cutaneous tuberculosis, revealing that fibrosis development in Mycobacterium tuberculosis-infected organoids is linked to the PI3K-AKT and AP1 pathways in fibroblasts, and suggesting the potential for antifibrotic treatment evaluation.

In this study, researchers found that the compound BMS-470539 induced a senescence-like state in fibroblasts from systemic sclerosis patients, reducing fibrosis-associated markers in vitro and decreasing skin thickness in a mouse model of skin fibrosis, suggesting a novel therapeutic strategy for managing fibroblast-driven diseases.

This study in diabetic db/db mice found that treatment with the antihypertensive agents minoxidil or nebivolol stimulated elastogenesis and inhibited elastolysis, leading to restored elastic fibers, reduced aortic stiffening, and normalized blood pressure.

In this review, researchers explored the roles of vitamins A, B3, C, D, and E in skin immunity, highlighting their potential as therapeutics for skin diseases due to their antioxidant, anti-inflammatory, and antimicrobial properties.

In this study, researchers using single nuclei RNA-sequencing found that fibroblasts in deeper layers of mouse skin expressed higher levels of pro-inflammatory genes post-wounding compared to other cells, highlighting their significant role in early inflammation and tissue repair processes.

This study demonstrated that SHFKO significantly accelerated healing in acute radiation-induced skin injuries, with mechanisms involving apoptosis inhibition, suppression of inflammation, and restoration of ROS balance, suggesting its potential as a novel multi-target therapy for radiodermatitis.

This study identified at least four distinct fibroblast populations in adult human skin, each with unique functional properties, suggesting potential therapeutic applications for wound healing and fibrosis-related diseases.

This review discusses the links between particulate matter exposure and skin diseases, highlighting oxidative stress and inflammation as key mechanisms; it reports no new clinical results.

This review discusses the role of reactive oxygen species in wound healing, highlighting potential strategies like mitochondrial-targeted antioxidants for managing non-healing chronic wounds, and reports no new clinical results.

This study found that adipose-derived mesenchymal stem cells produced more anti-inflammatory and pro-angiogenic cytokines on electrospun scaffolds, which enhanced wound healing and macrophage activity in a rat model.

Mammalian organs regenerate using stem cells and cell plasticity, but this ability declines with age.

This review discusses the cellular and molecular changes involved in cutaneous wound re-epithelialization and EMT, highlighting their similarities and differences, but reports no new clinical results.

This review discusses the historical development, mechanisms of action, and potential new clinical applications of the drug cepharanthine, highlighting its multi-faceted pharmacological properties; it reports no new clinical results.

This review discusses the role of signaling networks in sebaceous gland development and disorders, highlighting recent insights from mouse models and cell line studies, but reports no new experimental results.