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This review evaluates dihydrotestosterone's role in androgenic alopecia and proposes a model suggesting that chronic scalp tension and inflammation contribute to hair follicle miniaturization, identifying fibrosis, calcification, and tension as treatment targets.

This study found that the PSEN1-P242LfsX11 mutation in hidradenitis suppurativa influences cytokine and chemokine expression in macrophages, potentially affecting inflammatory responses.

This study found that Tsukushi facilitates wound healing in mice by regulating macrophage function and myofibroblast differentiation.

This study found that intracellular Toll-like receptors were significantly up-regulated in peripheral blood mononuclear cells of alopecia areata patients, suggesting a potential role in inflammatory signaling and pathogenesis.

This article discusses inflammatory perifollicular fibrosis and alopecia but provides no new research findings.

This review examines the role of autoinflammation and immune dysregulation in hidradenitis suppurativa, linking it to genetic factors and autoinflammatory syndromes, but highlights the need for further research to fully understand its pathogenic mechanisms.

In a mouse model of androgenetic alopecia, this study found that a safflower oil body nanoparticle loaded with human fibroblast growth factor 10 significantly improved hair regeneration and reduced associated microinflammation without significant toxicity.

This study observed that ethanol extracts of Lygodium japonicum spores significantly reduced inflammatory responses in LPS-stimulated murine macrophages in vitro by negatively regulating p38 MAPK and NF-κB.

This research notes that biologics and small molecules are effective for treating nail psoriasis and alopecia areata, albeit with precautions for adverse events, but no clinical trials have been published for their use in treating nail lichen planus and atopic dermatitis.

This study found that α-MSH may suppress IFN-γ-driven upregulation of ICAM-1 in human dermal fibroblasts, suggesting potential roles for melanocortins in inflammatory skin disorders beyond collagen synthesis effects.

This study analyzed 24 Japanese cases of fibrosing alopecia in a pattern distribution and found a distinctive "parachute" hair loss pattern, emphasizing unique clinical characteristics potentially influenced by racial factors.

In an animal study, researchers observed that simvastatin and Luteolin significantly increased hair growth and reduced hair loss in male mice, with improvements linked to their antioxidant and anti-inflammatory properties.

This study highlights a close link between metabolic syndrome, characterized by conditions like obesity and hypertension, and various inflammatory skin diseases, suggesting that mitochondrial dysfunction plays a key role in their pathogenesis and could be a target for new therapies.

This study found that the methanolic extract of Suaeda monodiana Maire exhibited antioxidant, antimicrobial, and photoprotective activities, suggesting its potential use in pharmaceutical formulations for treating skin diseases.

This study observed that inflammatory stimuli significantly altered gene expression in rat theca-interstitial cells, affecting pathways related to growth and androgen production, which are central features of polycystic ovary syndrome.

Higher levels of certain nerve-related proteins are linked to hair loss in women with scalp pain.

This paper outlines the chronic inflammatory skin disorder hidradenitis suppurativa, emphasizing its symptomatology, associated systemic diseases, known risk factors, and treatment strategies, including medical and surgical interventions depending on disease severity, while highlighting its significant impact on patients' quality of life.

This study developed the first patient-driven outcome set for psoriasis, emphasizing the importance of symptom control, treatment efficacy, confidence in care, and disease control as key factors for evaluating treatment success.

This review discusses the potential of P. polyphylla saponins to treat acne through antibacterial, anti-inflammatory, immunomodulatory, and antioxidant effects, noting that acne's complex pathogenesis makes this line of research promising for future studies.

This study found that hidradenitis suppurativa is associated with increased serum levels of hypoxia-inducible factor-1α, suggesting its role in the disease's pathogenesis and as a treatment target.

This review discusses multisystem inflammatory syndrome in adults (MIS-A) related to SARS-CoV2 and outlines the existing knowledge and unanswered questions, reporting no new clinical results.

In this study, successful treatment outcomes with platelet-rich plasma injections in patients with IC/BPS and rUTI were associated with specific cytokine concentrations, particularly lower TNF-α levels.

In this study, researchers observed that RE-ORGA, a preparation from Korean herbs, may help alleviate androgenic alopecia by promoting human dermal papilla cell proliferation, reducing 5α-reductase enzyme levels, and displaying anti-inflammatory properties, suggesting potential regulation of androgen receptor sensitivity.

This case study describes hair loss as a potential late complication of multisystem inflammatory syndrome in children, observed in a 7-year-old girl who developed Telogen effluvium 73 days post-diagnosis.

In this review, researchers explored the potential of cannabinoids, particularly cannabidiol, as a holistic treatment for acne vulgaris, highlighting their lipostatic, anti-inflammatory, antiproliferative, and antimicrobial effects in modulating acne-related factors like sebum production and inflammation.

This study, published in "Más Dermatol," explores how multiple factors contribute to hair loss, such as genetics, hormones, oxidative stress, microinflammation, and emotional stress, and highlights interventions targeting these causes to improve hair regrowth and quality of life.

This review found that intermittent fasting might benefit skin health by enhancing skin regeneration, delaying aging, and improving inflammatory skin conditions; however, most evidence is based on preclinical data, indicating a need for more human trials to confirm these findings.

This study found that inducing SOX2 in keratinocytes significantly reduced pressure ulcer formation after cutaneous ischemia-reperfusion injury by producing amphiregulin, which also reduced oxidative stress and apoptosis.

This study reports the case of a 12-year-old girl who developed psoriatic alopecia after increasing her dose of the TNF-α inhibitor adalimumab for Crohn's disease, emphasizing psoriatic alopecia as a phenomenon associated with these medications.

TNF-a may not be as involved in certain types of hair loss as previously thought.