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This study found that disrupting inflammasome signaling by eliminating caspase-1 and -11 in mice reduced skin inflammation and delayed the onset of disease, highlighting their role in skin disease pathogenesis.

This study found that Caspase-1, traditionally viewed as an inflammasome component, is secreted upon wounding and plays a novel role by triggering hair follicle stem cell migration into the epidermis, offering insights into epithelial hyperplasia mechanisms in inflammatory skin conditions.

In this laboratory study, researchers reported that Camellia sinensis seed flavonoids significantly reduced oxidative stress and inflammation in UV-irradiated skin cells by modulating key signaling pathways, highlighting its potential as a skincare ingredient for anti-inflammatory and anti-photoaging benefits.

This study found that ruxolitinib modulated inflammatory changes and stimulated growth factor signals by blocking the JAK-STAT pathway in an in vitro model of alopecia areata.

In this study, researchers found that people with Parkinson's disease showed higher levels of inflammasome proteins, including caspase-1, ASC, and IL-18, compared to healthy individuals, suggesting these proteins as reliable biomarkers for inflammation in PD.

This study found that platelet-rich plasma might support brain health by enhancing glial cell function and modulating immune responses in inflammation, indicating potential as a treatment for brain disorders.

This study suggests that in hidradenitis suppurativa, MMP-induced matrix alterations may contribute to inflammation by releasing active peptides and inflammatory factors in the extracellular matrix.

In this study, umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles were found to improve wound healing in type 2 diabetic mice by inhibiting macrophage pyroptosis and reducing oxidative stress levels.

This study found that finasteride treatment reduced caspase-1 expression, suggesting that androgens may influence immune processes in the hair cycle of androgenetic alopecia.

This study found that diffuse alopecia in HIV-1-infected patients is characterized by higher rates of follicular stem cell apoptosis compared to controls, suggesting a hair cycle disturbance associated with the infection.

This review discusses findings from genetic studies on acne, highlighting progress in understanding its molecular pathogenesis without reporting new clinical results.

This study found that sex hormones, specifically non-aromatizable androgens like DHT and A/T, significantly increase inflammatory cytokine expression in human adipocytes when stimulated by LPS.

In a mouse model, this study found that exposure to PM2.5 leads to significant postpartum hair loss, apparent via morphological changes and elevated markers of inflammation, apoptosis, and fibrosis, potentially exacerbated by changes in hormone receptors and stem cell populations.

Acne is linked to inflammation and insulin resistance, and is associated with various syndromes that require different treatments.

This study found that TPA induces apoptosis in pig renal epithelial cells by affecting cell cycle proteins, and activated ras can prevent this process.

This study found that silver nanoparticles biofabricated using Ostericum koreanum leaf extract inhibited inflammatory cytokine production in stimulated human mast cell lines, suggesting potential use in treating mast cell-mediated allergic diseases.

This article reviews the genetic and androgenic factors influencing the development of androgenetic alopecia and reports no new findings; the authors highlight a need for further research into the underlying mechanisms.

This study found that S. scabiei infestation in rabbits leads to epidermal thickening possibly due to apoptosis-related proliferation and keratinization of the skin.

This study found that using insulin-like growth factor 1 with bone marrow-derived mesenchymal stem cells in a collagen-chitosan scaffold enhanced wound healing and hair follicle regeneration in rats.

This study reports that taxifolin from enzymatic hydrolysis effectively regulates dermal papilla cell apoptosis and promotes hair growth by increasing IGF-1 and reducing TGF-β1, though it shows less inhibition of DHT compared to minoxidil.

In this review, researchers discussed recent insights into caspases, enzymes initially associated with cell death and inflammation, revealing their broader roles in cell proliferation, migration, and differentiation, and highlighting the importance of caspase knock-out mice for understanding their implications in diseases.

This research found that certain inflammasome proteins, like caspase-1, ASC, IL-18, and IL-1β, were elevated in patients with aneurysmal subarachnoid hemorrhage (aSAH) compared to controls and suggested these proteins could serve as reliable biomarkers for inflammation, potentially predicting worse outcomes.

This study found that topical application of TSG from Polygonum multiflorum promoted hair regrowth in depilated mice, potentially through the inhibition of apoptosis-related proteins.

This article reviews anthralin's pharmacology, mode of action, and its use for psoriasis and other dermatoses, but reports no new clinical results.

This study found that phenolic compounds from Quercus acutissima, particularly casuarinin, showed strong antioxidative, anti-inflammatory, and antiacne effects in mouse macrophage cells, suggesting potential therapeutic candidates for acne.

This review highlights advances in understanding inflammatory memory in epidermal stem cells, focusing on their capacity to remember prior inflammatory responses and respond more quickly to future stimuli, potentially aiding strategies against skin-related diseases.

This study found that etifoxine pretreatment reduced neuroinflammation and improved cognitive function in LPS-induced neuroinflammation in mice, potentially through increased neurosteroid synthesis and reduced apoptosis.

This study reported that fermented yeast complex extract may promote hair regrowth by modulating antioxidative and anti-inflammatory pathways in dermal papilla cells and increasing hair follicle numbers in an animal model.

This study found that in a mouse model, alopecia areata was associated with changes in heart structure, biochemistry, and gene expression linked to cardiac hypertrophy after ACTH exposure.

Inflammasome proteins can indicate the severity and treatment response of various diseases and injuries.