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In this study using a mouse model with alopecia areata, the researchers found that ruxolitinib enhances hair regrowth by inhibiting the JAK-STAT signaling pathway, reducing inflammation and oxidative stress, and decreasing apoptosis, which supports its clinical effectiveness in treating this condition.

This study suggests that Cepharanthine, a monomer in traditional Chinese medicine, may help treat COVID-19 by affecting multiple signaling pathways, and that TNF and IL-17 inhibitors used in rheumatoid arthritis, ankylosing spondylitis, and gouty arthritis might also be beneficial.

This study elucidates a mechanism for acne-like skin toxicity caused by EGFR/MEK inhibitors, involving an interaction with skin bacteria to trigger inflammation, which supports existing antibiotic treatment practices.

This study found that exosome-like nanoparticles derived from leeks promoted hair follicle stem cell proliferation and migration, enhanced antioxidant capacities, reduced inflammation, and inhibited hair maturation in rats by altering differentiation pathways, suggesting potential therapeutic benefits for managing hirsutism.

This review highlights that iron deficiency is a significant yet often overlooked contributor to the development of immune-mediated inflammatory skin diseases, suggesting that iron dysregulation may drive inflammation and metabolic imbalances in conditions like psoriasis and atopic dermatitis.

This study found that Melamax®, originally developed as an eco-friendly hair dye, provides significant protection against ultraviolet-induced oxidative and inflammatory damage in keratinocytes by modulating gene expression and signaling pathways, highlighting its dual potential for cosmetic coloration and skin photoprotection.

This study demonstrates that Bazi Bushen capsules may have therapeutic potential against skin photoaging in mice by enhancing NRF2 expression and targeting the KEAP1-NRF2 pathway.

In a human genetic study on hidradenitis suppurativa, researchers identified 12 genetic risk loci and found that CXCR4-CD74 signaling may play a key role in hair follicle inflammation, suggesting CXCR4 blockade as a potential therapeutic approach for this condition.

This study found that peimine treatment significantly improved wound healing and tissue regeneration in mice by enhancing wound closure, granulation tissue formation, and epidermal thickness, with effects linked to activation of the Notch1 signaling pathway.

This study found that sleep deprivation in mice can trigger prostatitis by activating the cGAS-STING pathway due to reduced levels of dihydrotestosterone and melatonin, resulting in a pro-inflammatory environment, while recovery sleep can mitigate these effects.

In this animal study, researchers observed that ginsenoside CK significantly reduced hair loss, improved sexual organ health, and encouraged hair growth in mice with androgenetic alopecia by modulating key signaling pathways and normalizing hormone metabolism, highlighting its potential as a therapeutic agent.

This study observed that among a Moroccan population with frontal fibrosing alopecia, common comorbidities included lichen planus pigmentosus (36.8%), rosacea (28.9%), thyroid disorders (23.7%), and dyslipidemia (21.1%), highlighting potential relationships mediated by shared inflammatory or metabolic pathways.

This study in mice found that a monoclonal antibody targeting EGFR resulted in skin inflammation mediated by TNFα, suggesting potential pathways for addressing EGFR antibody-induced skin rash in cancer patients.

In this study, exposure to m-Aminophenol in human keratinocytes altered the expression of thousands of genes involved in inflammation and stress responses, suggesting potential biomarkers for MAP-induced skin toxicity.

This study using a mouse model reports that CuATSM treatment accelerates skin wound healing and reduces scar formation, with effects possibly mediated via the ferroptosis-induced Hippo/YAP signaling pathway and macrophage polarization, suggesting CuATSM as a potential therapy for scarless wound healing in clinical settings.

This review summarizes the current understanding of Wnt signaling in relation to its roles in tissue regeneration and cancer progression and discusses recent medical advancements targeting this pathway for therapeutic purposes.

This review summarizes recent findings on how the dysregulated PI3K/Akt/mTOR pathway contributes to immune-mediated inflammatory skin disorders and discusses the potential of natural products, synthetic compounds, and biologic agents in their treatment. However, it emphasizes the need for further research to develop effective therapies.

This study found that α-ketoglutarate protected dermal papilla cells from oxidative stress by enhancing the Nrf2 pathway and mitigating cell damage through the ERK/Nrf2 axis.

This study demonstrated that Periplaneta americana extract significantly promoted hair regeneration in depilated mice by enhancing superoxide dismutase activity, upregulating vascular endothelial growth factor, modulating the FOXO/PI3K/AKT pathway, and restoring skin microbiome balance, suggesting its potential as a novel therapeutic candidate for alopecia.

This study identified three hub genes—BMP4, POSTN, and WNT5A—that are closely associated with keloid fibroblast hyperplasia, suggesting they may serve as potential biomarkers for inhibiting this condition. Further research is necessary to fully understand their roles in keloid development.

This study found that hypoxia-preconditioned HF-MSC-derived exosomes improved therapeutic outcomes in models of ulcerative colitis, potentially through miR-214-3p-mediated pathways affecting mitochondrial function and inflammatory responses.

This review compiled evidence suggesting that flavonoids may promote skin wound healing due to their anti-inflammatory, angiogenesis, re-epithelialization, and antioxidant properties, while also discussing current limitations and future prospects for these compounds as wound-healing agents.

This study discovered that TREM2 macrophages influenced by squalene play a role in acne's development by hindering the killing of Cutibacterium acnes, helping explain why benzoyl peroxide is effective in treatment.

The authors discussed that SOCS1 and SOCS3's inhibition of JAKs plays a significant role in the development of JAK inhibitor drugs for skin inflammatory diseases and malignancies.

This study found that fermented Flammulina velutipes polysaccharides showed higher antioxidant and anti-inflammatory capacities than non-fermented ones, suggesting potential use in functional foods and health products.

This study suggests that while Nanostring profiling identifies important processes in resolving MA-ARDS, solely targeting late-stage resolution by altering SPM production is not enough. The researchers conclude that combining multi-targeted adjunctive therapies with antimalarial drugs may be necessary to enhance survival and recovery.

This study found that Forsythiaside A may protect against sepsis-induced acute kidney injury in mice by reducing inflammation and apoptosis through modulation of ER stress responses.

This study found that using elastic nano-liposomes to deliver palmitoylethanolamide improved its transdermal delivery and enhanced its skincare effects, with minimal cytotoxicity and no allergic reactions observed.

In this study, cepharanthine showed potent antiviral effects against tick-borne encephalitis virus in vitro by reducing viral replication and inflammation in human lung and neuroblastoma cells.

In this study, finasteride significantly reduced plasma cholesterol and triglycerides and decreased atherosclerotic lesion burden in mice, suggesting its potential role in delaying cardiovascular disease.