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The reviewers found the manuscript on inflammation's role in cancer stem cells to be relevant but suggested it needs clarity, more background information, discussion on immune cells' role in tumors, updated references, and grammar corrections.

Nitric oxide is important for skin functions and both helps protect against and contributes to skin inflammation and sensitization.

Herbs might help with hair loss, but more research is needed to confirm their safety and effectiveness.

IL-1 family cytokines are crucial for skin defense and healing, but their imbalance can cause skin diseases.

Azelaic acid may help treat acne by killing bacteria, reducing inflammation, and preventing clogged pores.

Loss of OGG1 increases skin inflammation and auto-antibodies in lupus.

Wound healing is a complex process involving different cells and stages, leading to scar tissue formation and strength increase over time.

Putting thymidine dinucleotide on newborn mice's skin can delay and reduce skin cancer.

Eupafolin nanoparticles help protect skin cells from damage caused by air pollution.

The hydrogel with silver and ibuprofen promotes wound healing and fights infection.

The conclusion is that analyzing RNA from skin oils is a promising way to understand skin diseases.

High-dose radiation speeds up aging in skin stem cells.

Oregano extract helps fix testis and sperm damage caused by finasteride.

Hydrogel with M2-derived exosomes improves wound healing by slowly releasing exosomes that help reduce inflammation and promote tissue repair.

Male tissue has more cell death than female tissue after ischemia, and some neurosteroids only protect female cells.

17β-estradiol can reduce inflammation in the skin.

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

Both treatments for alopecia areata showed similar modest effectiveness.

Regulatory T-cells are important for healing and regenerating tissues in various organs by controlling immune responses and aiding stem cells.

Fisetin may help treat psoriasis and reduce skin inflammation.

Mitochondrial Complex I reduces inflammation and increases bone breakdown by affecting certain immune cells.

The conclusion suggests that treatments targeting root causes of chronic diseases may be developed by focusing on gene expression and lifestyle factors.

Topical aprepitant reduces skin rash and hair loss caused by cancer treatment.

The research confirms that Hidradenitis Suppurativa is characterized by increased inflammation, disrupted skin cell organization, and abnormal metabolic processes.

Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.

Phospholipase A2 enzymes play key roles in skin health and disease.

Hair aging is caused by stress, hormones, inflammation, and DNA damage affecting hair growth and color.

Disrupted cholesterol production impairs hair follicle stem cells, leading to hair loss.

Caffeine can stimulate hair growth, but the best dose and frequency for hair loss treatment are still unknown.

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.