January 2026 in “Journal of Cosmetics Dermatological Sciences and Applications” This review reports that while platelet-rich plasma shows promise as a safe treatment for various types of hair loss, variability in studies limits definitive conclusions on its effectiveness.
December 2025 in “Journal of AI” This study bibliometrically evaluated 5741 articles on PRP from 1980 to 2024, highlighting Türkiye's contribution and identifying prominent research areas such as orthopedics and wound healing.
December 2025 in “Lviv clinical bulletin” This review found that platelet-rich plasma therapy may enhance ovarian repair and fertility outcomes in ovarian insufficiency, but notes that optimal usage and long-term effects require further investigation.
December 2025 in “VNU Journal of Science Medical and Pharmaceutical Sciences” This review synthesizes evidence supporting the efficacy of PRP in dermatological conditions like wound healing and alopecia, but emphasizes the need for standardized protocols and larger randomized controlled trials.
September 2025 in “Dermatology and Therapy” This systematic review and meta-analysis found that platelet-rich plasma (PRP) therapy is effective in increasing hair density and reducing hair loss for alopecia, with variations in response based on activation status.
September 2025 in “Drug Design Development and Therapy” This study suggests that while platelet-rich products show promise in treating dermatological conditions like chronic wounds and skin aging, there is still a need for standardized methodologies and extensive trials to confirm their long-term clinical benefits.
August 2025 in “Research Square (Research Square)” This study observed that among male patients who experienced telogen effluvium after platelet-rich plasma treatment for androgenic alopecia, there were elevated levels of TNF-α, androgen receptors, and altered 5α-reductase gene expression, suggesting these factors as potential contributors to this unintended outcome.
This study evaluated the effect of intralesional injections of lyophilized Platelet Derived Growth Factors in 42 patients with Peyronie's disease and found significant reductions in penile curvature and plaque size, along with improvements in Peyronie's Disease Questionnaire scores, suggesting a potential treatment role.
January 2025 in “The World Journal of Men s Health” In this study, autologous intratesticular PRP injection was found to be a feasible and well-tolerated procedure with low complication rates and quick recovery, but the authors indicated that current evidence is insufficient to confirm its effectiveness for mTESE.
January 2025 in “Acta Clinica Croatica” This pilot study found that using platelet rich fibrin in combination with dressings after revascularization surgery in patients with critical limb ischemia accelerated wound healing compared to dressings alone.
This study developed a legally valid, evidence-based informed consent document specifically for platelet-rich plasma injections, intended to enhance patient rights and communication, and support legal defense in malpractice cases.
December 2023 in “International journal of multidisciplinary research and analysis” In this study, topical administration of secretome hypoxia mesenchymal stem cells gel increased IL-10 and decreased TNF-α gene expression in a fluconazole-induced alopecia-like model in rats, with the 40 μL dose having the most significant effect.
November 2023 in “Indian journal of surgery” This study found that platelet-rich gel is a simple and effective non-surgical method for healing exposed skull injuries, resulting in complete healing with minimal scars and sparse hair growth in all patients.
November 2023 in “International Journal of Medical Case Reports and Reviews” This review discusses the potential and current applications of platelet-rich plasma in otolaryngology and reports no new clinical results; the authors note varying evidence for its effectiveness across medical conditions.
May 2023 in “PARIPEX INDIAN JOURNAL OF RESEARCH” This study found that platelet-rich plasma, used as a sole treatment in male patients with androgenetic alopecia, may improve hair growth over a three-month period.
January 2023 in “Annali di stomatologia” This review traces the development and application of Platelet-rich Plasma in regenerative medicine, emphasizing its role in tissue healing and bone regeneration, but reports no new clinical results.
January 2023 in “Journal of orthopedics & bone disorders” This study suggests that platelet-rich plasma's high levels of growth factors may be limited in promoting bone regeneration due to the concurrent release of Dickkopf-1, which inhibits osteogenesis.
January 2020 in “Majalah Kedokteran Gigi Indonesia” The researchers reported that freeze-dried collagen-activated platelet-rich plasma increased transforming growth factor-β1 levels compared to non freeze-dried PRP with collagen, suggesting a potential benefit for tissue regeneration.
January 2019 in “Research Square (Research Square)” In this study, researchers will conduct a randomized, double-blind, multi-center clinical trial to assess the effectiveness of YH0618 granule in preventing chemotherapy-induced hair loss among breast cancer patients, aiming to understand its mechanism related to kidney deficiency in Chinese Medicine. Results are not yet reported.
January 2019 in “Springer eBooks” Platelet-rich plasma therapy may have benefits and is generally safe, but more research is needed to confirm its effectiveness and safety.
January 2013 in “Otorhinolaryngology clinics : an international journal” This review examines platelet-rich plasma's applications in aesthetic surgery and reports no new clinical results; the authors highlight its growing use and potential as a therapeutic modality.
June 2020 in “Aesthetic Surgery Journal” This study found that PRP with high estrogen levels increased hair density more effectively and earlier than autologous PRP in male patients with androgenic alopecia.
June 2020 in “Journal of Evolution of medical and Dental Sciences” This study found that platelet-rich plasma treatment effectively decreased hair fall and increased hair growth in male patients with androgenetic alopecia.
March 2019 in “European archives of medical research” In this study, PRP injections were found to improve hair density and quality in patients with androgenetic alopecia, with a significant reduction in hair loss and high patient satisfaction after three treatment sessions over several months.
11 citations
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June 2012 in “Archives of Dermatological Research” This study demonstrated that high doses of L-cystine and vitamin B6 effectively prevent doxorubicin-induced hair loss in mice.
This review concludes that platelet-rich plasma is a promising treatment for androgenetic alopecia, enhancing hair density and thickness, though outcomes vary due to differences in preparation and application methods.
15 citations
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May 1997 in “Annals of Internal Medicine” This case report describes a patient with breast cancer who developed female androgenetic alopecia after starting tamoxifen therapy.
348 citations
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July 2017 in “Skin appendage disorders” This review discusses the use of platelet-rich plasma in dermatology for various applications such as tissue regeneration and wound healing, but it reports no new clinical results and calls for clearer guidance on suitable treatments.
164 citations
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January 2014 in “Journal of Cutaneous and Aesthetic Surgery” This study found that PRP injections may improve hair density and reduce hair loss in patients with androgenetic alopecia without significant side effects, but further research is needed to confirm efficacy.
117 citations
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March 2017 in “Nature Communications” This study shows that macrophage-induced TNF signaling can activate hair follicle stem cells and promote new hair follicle formation after wounding by regulating AKT/β-catenin pathways.