Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

In this study, the administration of indole-based compounds, particularly L-Tryptophan and Tryptophol, to a PCOS-induced rat model resulted in an increased number of healthy ovarian follicles and a reduction in ovarian cysts compared to untreated rats, suggesting potential therapeutic efficacy.

This review discusses indole-based bifunctional aldose reductase inhibitors and antioxidants for diabetic complications and chronic inflammation-related pathologies, but reports no new clinical results.

In this study, a new herbal hair serum using a dual-phase system effectively reduced scalp flakiness and hair fall in a six-week trial, combining oil-based growth stimulants and water-based antimicrobial agents for comprehensive scalp and hair health.

This review synthesizes recent molecular and preclinical advances in alopecia areata and androgenetic alopecia, highlighting how interventions targeting specific intracellular signaling pathways and utilizing stem cell technologies can support precision regrowth and structural follicle reconstruction.

This study found that compound 3, a tetrahydropyridoindole carboxymethylated at position 5, significantly inhibited sorbitol accumulation in both rat eye lenses and tissues affected by diabetes, indicating its potential as a lead compound for ALR2 inhibition.

This review summarizes the biological process of melanogenesis and evaluates natural skin-whitening treatments based on their mechanisms affecting melanin production, aiming to inform on the effects and awareness of skin-bleaching creams.

In this study, phytochemical analysis and molecular docking suggested that bioactive compounds in several Ayurvedic herbs may interact persistently with hair growth and antifungal protein targets, indicating potential as plant-based treatments for dandruff and hair loss.

This study reported the development of new pyrazole-based MPC inhibitors that effectively inhibit mitochondrial pyruvate transport, showing potential as therapeutic candidates for conditions like metabolic dysfunction-associated steatohepatitis without activating PPARγ.

This study found that indole glycosides from Calanthe discolor Lindl. can significantly promote the proliferation of human hair follicle dermal papilla cells, potentially through upregulating specific growth factors.

This review highlights the potential of nanotechnology-based formulations in hair care and treatment, emphasizing how these innovative materials can enhance the stability, efficacy, and safety of active compounds while addressing the limitations of conventional formulations.

This review discusses the topical use of systemic drugs for cutaneous disorders and reports a lack of strong evidence from randomized controlled trials, highlighting the need for larger comparative effectiveness studies.

This study introduces MicrobeFDT, a tool that clusters chemically similar compounds and links them to gut microbial enzymes and toxicities, demonstrating its utility by uncovering previously unknown metabolism of the cancer drug altretamine.

This review summarized and classified 32 approved synthetic and natural-identical antioxidants, examining their regulatory status, safety, pharmacological properties, and effectiveness on human health, aiming to clarify their antioxidant actions and encourage further research in the field.

This research focused on formulating finasteride, dutasteride, and minoxidil with cyclodextrins to enhance their solubility and skin penetration for topical use, potentially reducing scalp irritation from current alcohol-based preparations.

This review discusses three classes of thiazole-bearing compounds in drug development and presents preclinical findings but reports no new experimental results, highlighting the need for further drug discovery.

This study identified eight isoflavone derivatives as potential nonsteroidal inhibitors of rat 5α-reductase using a pharmacophore model in virtual screening.

This study found that bis-benzylisoquinoline and Amaryllidaceae alkaloids, especially aromoline, show potential as antiviral agents, suggesting they could serve as foundations for developing new treatments against coronaviruses by enhancing the understanding of their structure-activity relationships.

This study presents a Cu-catalyzed atroposelective method achieving high stereoselectivity for synthesizing chiral biaryl N-oxides, with product 3e showing promising therapeutic efficacy against triple-negative breast cancer in cell lines MDA-MB-231 and MDA-MB-468.

This study found that hypaphorine alters cytoskeletal organization in Eucalyptus globulus root hairs, contributing to reduced root hair elongation by possibly disrupting vesicle delivery needed for growth.

This review highlights the potential of inorganic nanoparticle-based scaffolds as innovative tools for advanced wound care, emphasizing their ability to provide antimicrobial action and regenerative support, while also discussing fabrication strategies and challenges in optimizing their clinical application.

This study found that glutathione deficiency affects lateral root and root hair responses to indole butyric acid in plants, but not to indole acetic acid, indicating its role in auxin pathway regulation.

In this study, researchers analyzed the chemical constituents of male and female Gynostemma longipes plants and different parts like roots and leaves, identifying significant variations in metabolites which could aid in assessing and selecting quality medicinal materials.

This study evaluated a novel Dual-Phase Herbal Elixir aimed at managing hair fall and dandruff, finding that its unique oil and aqueous layers significantly reduced scalp flakiness and hair fall in a six-week trial, underscoring its potential as a natural hair care alternative.

This review summarizes the promising role of melatonin combined with nanosized carriers in drug delivery, suggesting enhanced effectiveness in treating various diseases compared to free melatonin.

This review discusses nearly 70 patent applications for the treatment of androgenetic alopecia and other hair conditions, highlighting the mechanisms of action explored but reports no clinical results.

This study developed chemical fingerprints to differentiate Eclipta prostrata and Wedelia calendulacea, two plants often confused and adulterated in the Indian herbal market, identifying distinct chemical profiles that can prevent such adulteration.

This review discusses current challenges in selective androgen receptor modulator discovery and preclinical evaluation and reports no new results, emphasizing the need for basic research to improve safety and selectivity.

This review discusses the potential uses of 5α-reductase inhibitors for conditions ranging from benign prostatic hyperplasia to skin disorders like acne and male pattern baldness, but it reports no new clinical results.

This review discusses the mechanisms of skin aging, highlighting the roles of stem/progenitor cells, genetic and environmental factors, and suggests potential for cell-based therapies, but reports no new experimental findings.

This review highlights the challenges in screening for steroid 5 alpha-reductase inhibitors and discusses significant variability in the effectiveness of finasteride and dutasteride, calling for standardized testing methods to develop safer, more specific inhibitors from herbal preparations.