81 citations,
February 2016 in “Veterinary pathology” Progeroid mouse models show signs of early aging similar to humans, helping us understand aging better.
May 2023 in “Journal of Investigative Dermatology” The research developed methods to test drugs that could protect and restore hair follicle protection in a hair loss condition.
Moles may stop growing because of cell cooperation, not just because of aging cells.
Moles may stop growing due to cell cooperation, not just because of individual cell aging.
69 citations,
June 2017 in “Experimental Biology and Medicine” Advanced human skin models improve drug development and could replace animal testing.
20 citations,
December 2019 in “Current Opinion in Systems Biology” The document concludes that computational models are useful for understanding immune responses and could improve cancer immunotherapy.
26 citations,
February 2013 in “Biochimica et Biophysica Acta (BBA) - General Subjects” The review found that different stem cell types in the skin are crucial for repair and could help treat skin diseases and cancer.
25 citations,
December 1992 in “Seminars in cell biology” Skin stem cells are maintained by signals from nearby cells and vary in their ability to renew and mature.
5 citations,
October 2012 in “Journal of Investigative Dermatology” Scientists can mimic hair disorders by altering genes in lab-grown human hair follicles, but these follicles lack some features of natural ones.
3 citations,
March 2023 in “Scientific Reports” Researchers developed a new method to test hair growth drugs and found that adult cells are best for hair growth, but the method needs improvement as it didn't create mature hair follicles.
A mix of Polygonatum sibiricum and Nelumbinis semen may ease menopause symptoms with fewer side effects.
63 citations,
May 2011 in “Clinical cancer research” The topical inhibitor CUR61414 was not effective in treating basal cell carcinoma in human trials.
44 citations,
March 2011 in “Journal of biotechnology” Scientists recreated human hair follicles in the lab that can grow hair.
31 citations,
January 2014 in “Advances in Clinical and Experimental Medicine” Stem cells could improve plastic surgery but are not widely used due to cost and safety concerns.
5 citations,
October 2021 in “BioMed Research International” Noncrosslinked hyaluronic acid helps human hair cells grow and could be a potential hair loss treatment.
237 citations,
June 2013 in “Nature Medicine” A protein from certain immune cells is key for new hair growth after skin injury in mice.
188 citations,
October 2012 in “The AAPS Journal” The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.
116 citations,
May 2013 in “Proceedings of the National Academy of Sciences of the United States of America” Hair grows faster in the morning and is more vulnerable to damage from radiation due to the internal clock in hair follicle cells.
89 citations,
August 2013 in “PloS one” Androgen receptors are active in many tissues of both male and female mice, not just reproductive organs.
12 citations,
February 2010 in “Asian Journal of Animal and Veterinary Advances” Young and adult hamsters both respond similarly to testosterone and finasteride treatments, but young hamsters aren't good for testing the inhibitory activity of a specific enzyme.
9 citations,
May 2021 in “Frontiers in aging neuroscience” Taking triterpenoids from Ganoderma lucidum over a long time can help slow down brain aging and improve overall health in mice.
9 citations,
July 2001 in “Cell” Cells from certain embryo parts can induce head formation in another embryo, involving complex signaling pathways.
7 citations,
January 2020 in “PubMed” Stem cell therapies show promise for treating hair loss, but more research is needed to understand their safety and effectiveness.
February 2024 in “Tissue & Cell” New tissue engineering strategies show promise for regenerating human hair follicles, which could improve hair loss treatments.
February 2023 in “Frontiers in Bioengineering and Biotechnology” Optical imaging and light therapy show promise for diagnosing and treating liver injury caused by surgery.
November 2008 in “Medical & surgical dermatology” A device was made in 2008 to measure hair loss severity. Other findings include: frizzy mutation in mice isn't related to Fgfr2, C/EBPx marks preadipocytes, Cyclosporin A speeds up hair growth in mice, blocking plasmin and metalloproteinases hinders healing, hyperbaric oxygen helps ischemic wound healing, amniotic membranes heal wounds better than polyurethane foam, rhVEGF165 from a fibrin matrix improves tissue flap viability and induces VEGF-R2 expression, and bFGF enhances wound healing and reduces scarring in rabbits.
January 2008 in “Annals of Nutrition and Metabolism” Parthenolide promotes hair growth in mice and may influence pathways related to male pattern baldness.
124 citations,
June 2020 in “Cell Stem Cell” Fat cells in the skin help start healing and form important repair cells after injury.
54 citations,
February 2013 in “The journal of investigative dermatology/Journal of investigative dermatology” Vitamin A affects hair loss and immune response in alopecia areata.
52 citations,
July 2001 in “Molecular and cellular endocrinology” Activin A helps heal skin wounds and protects the brain after injury.