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This study identified 29 Moroccan medicinal plants containing compounds that may act as natural inhibitors of SARS-CoV-2 based on molecular docking and in-silico analyses.

In this study, in silico screening and molecular simulations identified β-sitosterol and brassicasterol as stable potential inhibitors of 5α-reductase1, suggesting they could be explored for androgenic alopecia treatment.

In this study, phytochemical analysis and molecular docking suggested that bioactive compounds in several Ayurvedic herbs may interact persistently with hair growth and antifungal protein targets, indicating potential as plant-based treatments for dandruff and hair loss.

This study identified procyanidin B2 and leucopelargonidin from Saraca asoca as potential inhibitors in PCOS by showing high binding energy scores against key enzymes involved in estrogen and testosterone biosynthesis.

This study used molecular docking to identify stiripentol as a potential new inhibitor of the SRD5A2 enzyme, which is targeted for treating androgen-related diseases; however, in vivo trials are needed to validate its efficacy.

In in-vitro experiments, this study found that poncirin showed higher inhibitory activity against JAK3 than tofacitinib, suggesting potential for alopecia areata treatment.

This study found that methanolic extract of Eclipta alba leaves exhibited strong antibacterial effects against certain pathogens including methicillin-resistant Staphylococcus aureus, but it showed no activity against Mycobacterium tuberculosis, including drug-resistant strains.

This study identified five FDA-approved drugs—cepharantine, clofazimine, metergoline, imatinib, and efloxate—as potential candidates for repurposing to interfere with viral entry in COVID-19 treatment.

This study identified five FDA-approved drugs, including cepharantine and clofazimine, as potential COVID-19 therapies through in silico and in vitro screening targeting viral entry mechanisms.

This study presented a new two-dimensional model that successfully predicts transdermal permeation of caffeine, highlighting the significant role of the follicular pathway in increasing systemic bioavailability.

This study investigates the potential of onion extract as a treatment for androgenetic alopecia by using in silico and ADME/T analyses to examine how active compounds from onions interact with the 5-alpha-reductase enzyme.

This study identified 19 specific genes involved in root hair growth and morphogenesis in Arabidopsis, using a combination of computational and experimental methods.

This study used an in silico/in vitro approach to identify potential inhibitors of the enzyme SRD5A2, finding that the androgen receptor modulator MK-0773 is a moderate inhibitor, although it does not act as a covalent inhibitor like finasteride.

In this study, the researchers identified that perturbing both AKT1 and MDM2 significantly reduces epithelial-mesenchymal transition in melanoma, proposing Cialis and Finasteride as potential therapeutic candidates with favorable properties for managing aggressive melanoma.

This study identified new potential targets and indications for several marketed drugs using in silico profiling, suggesting opportunities for drug repositioning.

This study demonstrated that a computational screening process can identify existing drugs and natural compounds with potential anti-COVID-19 activity, highlighting some candidates for further experimental validation.

This study highlights the role of bioinformatics and in-silico studies for identifying drug targets, specifically in herbal drugs, using software and modern techniques to analyze data and model disease pathways before later-stage in vivo and in vitro testing.

This study predicted that 6-hydroxy genistein, coreximine, and scoulerine from Dadap leaves may act as anti-alopecia agents by interacting with JAK2, but further in-vivo testing is needed.

This study identified several compounds from traditional Chinese medicines that may inhibit prostaglandin D2 synthase, potentially providing promising candidates for treating androgenic alopecia with minimal adverse skin reactions.

This study analyzed watercress oil and confirmed its phytochemical profile, UV absorption properties, and potential efficacy for hair growth, supporting traditional hot oil applications.

In this study, researchers reported that compounds from Bruguiera gymnorhiza leaves showed anti-inflammatory potential in in silico analyses, with favorable drug properties and specific binding to the IKKβ receptor, suggesting possible development into anti-inflammatory drugs.

This study found that the transcriptome of skin stem cells in mice changes significantly with age, revealing specific age-dependent biological programs and transcriptional hubs.

This study used molecular docking simulations to identify approved drugs, including Bedaquiline and Telmisartan, with potential to treat Onchocerca volvulus infections by inhibiting key protein targets, suggesting these drugs could be repurposed for onchocerciasis treatment with further validation.

This source describes the implementation of a province-wide lung cancer screening program in Ontario, emphasizing that organized, program-based low-dose CT screening for high-risk populations is seen as more effective in reducing cancer incidence and mortality, while being cost-effective compared to non-organized screenings.

This study found that using nanoporous silica entrapped lipid-drug complexes enhanced the solubility and bioavailability of dutasteride in beagle dogs.

This study identified 30 new compounds with significant androgen receptor binding affinity through a combination of virtual screening and in vitro testing.

This study identified 26 bioactive compounds in the ethanol extract of Indigofera tinctoria leaves, which are linked to various therapeutic activities, supporting its traditional medicinal use in treating numerous health conditions.

This molecular docking study reported that danoprevir, remdesivir, and saridegib exhibit stronger binding affinities to the main protease of SARS-CoV-2 than the control, suggesting their potential as inhibitors of the virus's replication process.

This study found that the ethyl acetate extract of Semecarpus anacardium leaves demonstrated cytotoxicity against MCF-7 cancer cells and induced apoptosis, suggesting potential as a cancer treatment with fewer side effects.

This study identified 14 different phytoconstituents in the methanolic fruit extract of Citrullus colocynthis, suggesting its potential pharmacological importance.