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This review highlights that skin organoids, advanced three-dimensional models mimicking human skin, are emerging as effective alternatives to traditional culture models and human skin, overcoming limitations of two-dimensional systems and ethical concerns, and are being increasingly used in areas like developmental biology and disease modeling.

This review outlines the potential of using human pluripotent stem cells for hair follicle bioengineering, detailing current HF morphogenesis and cycling knowledge, various cell sources, and strategies using iPSCs, while discussing the challenges and prospects for therapeutic use in addressing hair loss.

In this viewpoint, researchers discussed the possible role of the developmental origin of scalp dermis in influencing the specific pattern of hair follicle miniaturization seen in male pattern hair loss, noting that frontal follicles are more susceptible while occipital follicles remain largely terminal.

This study reported that an HS-associated NCSTN mutation in iPSC-derived skin organoids led to altered hair follicle stem cell differentiation and increased expression of proteins linked to HS inflammation.

This study found that skin organoids derived from iPSCs with an HS-associated NCSTN mutation showed defects in hair follicle stem cell differentiation and increased expression of inflammatory proteins related to hidradenitis suppurativa.

This study found that dysregulation of the DNA damage response in stem cells is a common factor of aging, affecting tissues like the skin, brain, kidneys, and intestine.

This study found that carefully engineered hydrogels and asymmetric morphogen gradients facilitated the formation of anatomically relevant skin organoids from iPSC-derived EBs, improving pigmentation and hair follicle generation.

This article presents Stemson Therapeutics' development of a stem cell-based approach to generate new hair follicles for treating hair loss, which remains in preclinical stages without tested human results.

This study demonstrated that gene-corrected 3D skin constructs from RDEB patient-derived iPSCs, grafted onto immunocompetent mice, showed normal collagen VII expression after two months.

The researchers reported that iPSCs derived from Sendai virus reprogrammed blood cells can mature into functional keratinocytes for up to 60 days, potentially offering new approaches for DEB treatment.

This study found that long-term hair follicle stem cells originate from embryonic progenitor cells in a niche with reduced Wnt/β-catenin signaling, which is essential for their specification.

This study found that human hair follicles can be used to generate induced pluripotent stem cells, which can then efficiently differentiate back into keratinocytes.

This review discusses the potential of using human pluripotent stem cells to generate new hair follicles, though practical challenges remain before it can be applied for hair restoration.

This study found that human iPSC-derived dermal papilla precursor cells can regenerate hair follicle structures, offering a potential new treatment approach for permanent alopecia.

HA-iMSC-EVs can improve skin aging by boosting cell growth and restoring collagen and elastin.

In this study, researchers found that the microRNA profiles of induced pluripotent stem cells (iPSCs) derived from different adult cell types are largely similar, although each line exhibits some unique gene expression, distinct from both their cells of origin and embryonic stem cells.

In this study, researchers developed a method to differentiate human iPSCs into cells that can generate all lineages of hair follicles, potentially aiding treatments for hair loss and skin disorders.

This review explores the immunopharmacological potential of A. lappa for inflammatory musculoskeletal disorders (IMSDs) but reports no new clinical results, emphasizing the need for standardized research methodologies.

This study concluded that MEX3A is critical for maintaining Lgr5+ intestinal stem cells by regulating the PPARγ pathway, impacting intestinal homeostasis during postnatal development in mice.

This study found that using induced pluripotent stem cell-derived mesenchymal stem cells with acellular nerve allografts significantly improved axon regeneration and functional recovery in rats with sciatic nerve injuries, suggesting a promising approach for clinical nerve repair therapies.

This review discusses methods for generating induced pluripotent stem cells and highlights their recent applications in studying and treating COVID-19, but it reports no new experimental results.

This article reviews the development and use of induced pluripotent stem cell models and artificial organoids for studying neurodevelopmental disorders, but it reports no new clinical findings.

This study investigated transcription factors in human trophectoderm cells during development, finding that GATA2 and GATA3 are essential for transforming stem cells into induced trophoblast stem cells, which display characteristics similar to placental progenitor cells, offering new methods for modeling placental-associated diseases.

This study found that mouse astrocytes formed cell spheres on agarose surfaces, acquired stem cell-like features, and their derived stem cells effectively differentiated into neurons that helped regenerate damaged nerves.

This study demonstrated that EVs from pluripotent stem cell-derived mesenchymal stem cells improved recovery and function in ischemic lower limbs by enhancing angiogenesis through the ERK/MAPK signaling pathway.

This study observed that activating Wnt signaling pathways increased the efficiency of reprogramming human fibroblasts into induced pluripotent stem cells compared to untreated cells.

This review discusses the roles of hypoxia and epigenetics in cellular reprogramming and their contributions to tissue regeneration, reporting no new experimental results.

This review summarizes evidence suggesting that metabolism actively influences stem cell fate in intestinal and hair follicle stem cells, rather than being a mere environmental byproduct.

This study found that glycolysis in Paneth cells provides lactate to support mitochondrial oxidative phosphorylation in intestinal stem cells, aiding their function and differentiation.

In this study, fibroblasts from long-term skin biopsy cultures retained their ability to reprogram into induced pluripotent stem cells after 16 months, despite undergoing transcriptional changes and decreased proliferation rates over successive generations.