3 citations
,
April 2017 in “Zahedan Journal of Research in Medical Sciences” This study observed that nearly all kidney transplant patients experienced complications from immunosuppressive therapy, with excessive hair growth and increased blood sugar being the most common issues.
20 citations
,
January 1995 in “Journal of Dermatological Science” This study found that topical application of cyclosporin A and FK506 induces new hair growth in mice, while ascomycin and rapamycin do not, suggesting hair induction is not due to immunosuppression.
August 1994 in “Journal of dermatological science” Cyclosporin A and FK506 can start new hair growth in mice, but ascomycin and rapamycin cannot.
11 citations
,
January 2017 in “Oxidative medicine and cellular longevity” This study found that antroquinonol inhibited CD8+ T cell proliferation and reduced proinflammatory cytokine secretion in vitro, while also ameliorating H2O2-induced depigmentation and resisting reductions in hair follicle length, skin thickness, and tyrosinase expression in mice.
May 2024 in “International journal of medicine and psychology.” In this study, researchers observed that transcranial electrical stimulation in COVID-19 patients with mild to moderate symptoms led to a trend of greater reduction in interleukin-10 levels and interleukin-10/lymphocyte ratio compared to standard treatment alone, suggesting potential impacts on immunosuppression mechanisms that warrant further investigation.
April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” The researchers reported that DHT may reduce the inflammatory responses induced by C. acnes in androgen-sensitive human sebocyte cells, suggesting a potential link between androgens and infection in sebaceous disorders.
August 1994 in “Journal of dermatological science” Different substances affect hair and skin cell growth in various ways.
January 2016 in “Vojnosanitetski Pregled” Some treatments for inflammatory bowel disease can cause skin problems like rashes and melanoma.
28 citations
,
January 2000 in “Medical Mycology” This article reviews the impact of natural fungal pathogens on laboratory animal research and reports no new results, calling attention to infection risks with dermatophytes, Candida, and pneumonia in immunocompromised rodents.
155 citations
,
August 1991 in “Journal of The American Academy of Dermatology” This article reviews methotrexate's pharmacokinetics and toxicity, emphasizing the role of urinary excretion and leucovorin in avoiding most toxic reactions; it provides no new clinical results.
2 citations
,
January 2015 in “Indian dermatology online journal” This case report describes a 30-year-old woman with vitiligo who developed a rare dermatophyte infection encircling one of her vitiligo patches, possibly due to immunosuppression from her treatment.
1 citations
,
May 2024 in “International Journal of Molecular Sciences” This study suggests that targeting adenosine receptors could be an effective strategy for reducing inflammation in inflammatory skin disorders, with promising results observed in animal models.
July 2024 in “International Journal of Dermatology Venereology and Leprosy Sciences” This study suggests that topical minoxidil could promote hair regrowth in individuals with alopecia areata by exerting a localized immunosuppressive effect, and that combining minoxidil with other treatments may enhance hair growth outcomes.
April 1982 in “Journal of The American Academy of Dermatology” Retinoids help treat psoriasis effectively, but they can cause side effects and need more research on safe use with other treatments.
January 1989 in “Side effects of drugs annual” This chapter reviews studies on the side effects of cytostatics and immunosuppressive drugs, detailing various toxicities such as cardiovascular, pulmonary, and neurotoxicity, but provides no new clinical results.
23 citations
,
October 2005 in “Journal of The American Academy of Dermatology” This report describes the unexpected development of alopecia areata in kidney-pancreas transplant recipients undergoing cyclosporine-based immunosuppressive therapy, suggesting a complex relationship between the treatment and disease.
1 citations
,
October 2018 in “InTech eBooks” This article reviews treatment approaches for cicatricial alopecia, describing how medication efficacy varies and suggesting autologous hair transplantation for stable cases; no new clinical data are presented.
33 citations
,
October 2013 in “Cutaneous and ocular toxicology” This article discusses the autoimmune pathogenesis of alopecia areata and reviews the use of immunosuppressive therapies in its treatment, but it does not provide new clinical results.
This review discusses cyclosporine A's mechanisms of action and side effects compared to tacrolimus in renal transplantation, but it reports no new experimental results; the authors highlight implications for cardiovascular risk management.
54 citations
,
July 1994 in “Journal of Dermatological Science” This study found that topical application of FK506 stimulated hair growth in animals, which may occur independently of its immunosuppressive effects, though its effect on human hair growth remains unclear.
13 citations
,
August 2024 in “iScience” This study found that 3D spheroid culture reprogrammed mesenchymal stem cells into a uniform immunosuppressive phenotype, suggesting potential therapeutic applications for inflammatory diseases like psoriasis.
5 citations
,
August 1976 in “Biochemical Society transactions” This review discusses the effects of steroids on the skin and does not report any new research findings.
31 citations
,
July 1975 in “PubMed” This study reported that intensive immunosuppression in multiple sclerosis patients significantly reduced relapse rates versus pre-treatment expectations, though some required ongoing treatment after tapering.
This case report highlights hair loss as a side effect of tacrolimus-based immunosuppression in a kidney transplant patient, improving after switching to cyclosporine A. The authors emphasize the importance of monitoring and managing such side effects to ensure treatment adherence and patient well-being.
3 citations
,
February 1976 in “Pediatric Clinics of North America” This article discusses the factors influencing anticancer therapeutic regimens and reviews mechanisms of action and side effects of major chemotherapeutic agents without reporting new research findings.
19 citations
,
December 2008 in “Arthritis Care & Research” This study found that the decision board is a reliable and valid tool for assessing treatment preferences in systemic lupus erythematosus patients, who tended to favor oral medication due to concerns about side effects.
May 2026 in “Case Reports in Dermatology” This case report detailed a 31-year-old kidney transplant recipient who experienced significant hair loss linked to tacrolimus-based immunosuppression, which improved after switching to cyclosporine A, emphasizing the importance of awareness and management of hair-related side effects in transplant patients.
1 citations
,
May 2023 in “Prospects in Pharmaceutical Sciences” This study reviews current treatments for alopecia areata, highlighting that despite various options like corticosteroids and immunosuppressives, their limited efficacy and potential side effects are challenges, while targeting specific cytokines has shown promise except with TNF inhibitors, which may worsen the condition.
July 2025 in “Clinical Dermatology Review” This report presents a rare case where a patient with chronic urticaria developed alopecia areata during azathioprine therapy, accompanied by bone marrow suppression; these effects resolved after stopping the medication, suggesting a possible link between azathioprine and autoimmune activation despite its intended immunosuppressive use.
8 citations
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September 2006 in “Transplantation” In this reported case, an immunosuppressive regimen including tacrolimus and mycophenolate mofetil was associated with a total regression of hidradenitis suppurativa activity over one year, while cyclosporine alone had no effect.