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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

The document provides a method to classify human hair growth stages using a model with human scalp on mice, aiming to standardize hair research.

Planarian regeneration begins with a specific gene activation caused by injury, essential for healing and tissue regrowth.

Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.

Noggin is necessary to start the hair growth phase in skin after birth.

The Multi-Organ-Chip improves the growth and quality of skin and hair in the lab, potentially replacing animal testing.

PGD2 stops hair growth and is higher in bald men with AGA.

Lactate production is important for activating hair growth stem cells.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

Researchers created human hair follicles using a new method that could help treat hair loss.

Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.

Special fiber materials boost the healing properties of certain stem cells.

Regenerated fully functional hair follicles using stem cells, with potential for hair regrowth therapy.

Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.

Different types of skin cells have unique genetic markers that affect how likely they are to spread cancer.

Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.

Scientists made working salivary glands in mice using bioengineered cells, which could help treat dry mouth.

CDP is crucial for lung and hair follicle cell development.

Testosterone therapy in transgender men has both desired effects like increased muscle mass and potential health risks such as higher cardiovascular risk.

Blood vessels and specific genes help turn cartilage into bone when bones heal.

Telocytes might help with skin repair and regeneration.

Stress-related substance P may lead to hair loss and negatively affect hair growth.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Understanding hair growth involves complex interactions between molecules and could help treat hair disorders.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Cathepsin L is essential for normal hair growth and development.

Aging causes skin stem cells to work less effectively.