56 citations
,
January 2021 in “Clinical and Experimental Medicine” This review highlights the challenges in treating alopecia areata, noting that current therapies often lead to relapse and have uncertain long-term effectiveness; it also points to potential future treatments such as JAK-STAT inhibitors and PRP.
In this study, a clear pattern of selective sweep was observed for the SLC24A5 gene, with high linkage disequilibrium and low haplotype diversity, but no clear correlation with UV radiation intensity was found.
April 2024 in “Dermatovenerologiâ, kosmetologiâ” This material provides comprehensive information about actinic keratosis, highlighting its potential outcomes, risk factors, clinical features, diagnosis, and treatment considerations for medical specialists.
April 2024 in “Dermatovenerologiâ, kosmetologiâ” This study provides a comprehensive overview of actinic keratosis, highlighting its potential to progress to squamous cell carcinoma and noting that routine treatment poses a significant burden on healthcare providers.
30 citations
,
July 2019 in “PloS one” This study found that T-regulatory cells, specifically the FOXP3 CD39 subset, were significantly reduced in both circulation and hair follicles of alopecia areata patients compared to healthy subjects, suggesting potential therapeutic targets.
49 citations
,
January 2018 in “Immunology” This review discusses the relationship between psoriasis and autoimmunity, focusing on autoimmune co-morbidities, but reports no new research findings.
5 citations
,
November 2021 in “Skin appendage disorders” This review discusses the quality of life impact of hair loss disorders and potential psychological treatment approaches but reports no new clinical results.
57 citations
,
March 2021 in “International Journal of Molecular Sciences” This study found that type 2 immunity may play a role in the development of alopecia areata in patients with extrinsic atopic dermatitis, indicating different immunological states compared to non-atopic patients.
February 2024 in “Recima21” This study explored the connections between Covid-19 and hair loss issues like telogen effluvium and alopecia areata, highlighting the virus's potential trigger effect and underscoring the importance of comprehensive post-Covid-19 treatment strategies that consider immune, psychological, and hair cycle factors.
421 citations
,
April 2012 in “The New England Journal of Medicine” Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.
82 citations
,
October 2019 in “Frontiers in Immunology” This review discusses the features of regulatory T cells and the modulation of Foxp3, emphasizing post-translational modifications' impact on Treg function but reports no new clinical results.
50 citations
,
March 2000 in “American Journal of Clinical Dermatology” This article discusses the etiology, clinical features, and treatment of alopecia areata but presents no new clinical findings, underlining the palliative nature of current therapies.
27 citations
,
December 2015 in “Mayo Clinic Proceedings” This review presents an evidence-based algorithm for managing hidradenitis suppurativa in primary care, highlighting the need for more research on treatment effectiveness and the disease's pathogenesis.
3 citations
,
May 2023 in “Biomedicines” This article reviews the immunometabolic mechanisms linking polycystic ovary syndrome to infertility and stresses the need for interdisciplinary approaches to treat PCOS-related fertility issues; it reports no new clinical results.
3 citations
,
July 2017 in “Elsevier eBooks” This article reviews the identification and assessment of cutaneous drug reactions, emphasizing the importance of early recognition and the need for accurate diagnosis to prevent serious complications; it reports no new clinical results.
1 citations
,
April 2016 in “CRC Press eBooks” Skin aging reflects overall body aging and can indicate internal health conditions.
1 citations
,
November 1976 in “Archives of Dermatology” This article discusses the role of clinical observation and microscopic correlation in American dermatology training and reports no new clinical results.
January 2022 in “Medical research archives” This article reviews the potential role of vitamin D supplementation as an adjunct to alemtuzumab therapy in multiple sclerosis management, noting its possible benefits for autoimmune comorbidities and patient adherence, but reports no new clinical results.
156 citations
,
August 2016 in “Journal of controlled release” This review summarizes current knowledge on tight junctions in mammalian skin and their role in drug delivery and interaction with other barrier components, but reports no new experimental results.
1 citations
,
June 2001 in “Annals of Internal Medicine” This letter critiques a review of distant healing studies, highlighting significant methodological issues and limited evidence for its efficacy.
January 2020 in “Annals of the Academy of Romanian Scientists Series of Medicine” This article discusses the proposed role of immunologic responses to staphylococcal superantigens in folliculitis decalvans and reports no clinical results; treatment should be tailored to the disease's severity.
June 2001 in “Annals of Internal Medicine” This letter highlights the challenge of implementing ethical principles in healthcare due to society's dependence on financial systems, suggesting this may hinder public health and environmental well-being.
378 citations
,
February 2020 in “Nature Reviews Endocrinology”
55 citations
,
July 2016 in “Dermatologic Therapy” This article reviews treatment options for androgenetic alopecia and suggests that therapy should be personalized and targeted at various pathophysiological aspects, but reports no new clinical findings.
26 citations
,
June 2012 in “The Journal of Obstetrics and Gynecology of India” This review discusses various skin changes during pregnancy, noting that while most are benign and resolve after childbirth, some may require careful medical management for the safety of the mother and fetus; it reports no new results.
15 citations
,
January 2018 in “Acta dermato-venereologica” This study found that dermatological treatments significantly reduce health-related quality of life among patients with various skin conditions, suggesting that the burden of these therapies should be considered in treatment planning and development.
2 citations
,
July 2023 in “Toxics” This study observed that high concentrations of rosemary and thyme extract caused thymic tissue damage, decreased IgM and IgG levels, and fluctuated IL-10 levels in chick embryos, with inflammation signs present despite potential benefits.
May 2026 in “Aesthetic Cosmetology and Medicine” This study outlined the complexities of common scalp conditions like dandruff and alopecia, emphasizing the need for comprehensive treatment strategies that include modern diagnostic techniques and address underlying factors to enhance therapy effectiveness and improve patients' quality of life.
December 2025 in “Cureus” In this case report, a unique immunological mechanism was observed in an 11-year-old girl where the presence of one autoimmune disease appeared to prevent the manifestation of another, leading to the withdrawal of one type of lesion when another appeared.
November 2024 in “Revista fisio&terapia.” This literature review found that among therapies for Alopecia Areata, Janus kinase inhibitors are particularly promising despite safety challenges, while newer approaches like stem cells face cost and complexity issues; a comprehensive approach integrating medical and emotional support was emphasized for improving patient outcomes.