6 citations
,
March 2019 in “Medical science monitor basic research/Medical science monitor. Basic research” This study found that phosphorylated VEGFR-2 is present in human scalp epidermal appendages and suggests it plays a role in their daily regulation.
April 2020 in “Journal of animal research” In this study, researchers identified hair follicle stem cells in the bulge region of canine hair follicles, suggesting potential applications for future translational research.
March 2022 in “International Journal of Health Sciences” In this animal study, topical pentoxifylline was associated with improved hair regrowth in cyclophosphamide-induced hair loss in male Swiss albino rats.
20 citations
,
May 2016 in “Journal of Cutaneous Pathology” This study suggests that the presence and arrangement of plasmacytoid dendritic cells can help distinguish chronic cutaneous lupus erythematosus from other types of scarring alopecia.
5 citations
,
February 2008 in “Histopathology” This article discusses CD10 immunohistochemistry in prurigo nodularis and reports no new research findings.
4 citations
,
November 2016 in “Journal of Cutaneous Pathology” This letter discusses three plasmacytoid dendritic cell-related parameters that may help differentiate lupus alopecia from lichen planopilaris, but it reports no new study results.
5 citations
,
October 2021 in “Journal of the American Academy of Dermatology” PRAME helps distinguish between benign and malignant skin cells in most cases.
15 citations
,
December 2013 in “Clinical Cosmetic and Investigational Dermatology” This study found that levels of the protein MAGP-1, important for skin elasticity, decrease with aging and photoexposure, potentially contributing to skin fragility, sagging, and enlarged pores.
1 citations
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December 2012 in “Journal of dermatological science” This study introduces ficlatuzumab, an anti-HGF monoclonal antibody, in combination with gefitinib in a phase 2 trial to address EGFR TKI resistance in Asian NSCLC patients.
1 citations
,
October 2025 in “Frontiers in Cardiovascular Medicine” This review examines AAS-related deaths and finds that anabolic-androgenic steroid abuse may lead to severe cardiac abnormalities, contributing to fatal arrhythmias and sudden cardiac death in young athletes and bodybuilders.
835 citations
,
October 2008 in “Nature Genetics” Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.
272 citations
,
September 2001 in “Journal of Biological Chemistry” This study cataloged human type II hair keratins, detailing their expression and differentiation roles in hair follicles and comparing them with type I keratins to explore keratin-pairing principles.
157 citations
,
October 2002 in “Journal of Cutaneous Pathology” This study suggests that p63 is consistently expressed in the basal cells of the skin and may influence differentiation and the development of common skin carcinomas.
128 citations
,
February 1992 in “British Journal of Dermatology” The researchers reported that basal cell carcinoma tumor cells strongly express keratins typical of basal keratinocytes and some hair follicle components but lack differentiation markers, suggesting a follicular or pluripotent stem cell origin.
69 citations
,
September 1991 in “Journal of Surgical Research” This review highlights the unique scarless wound healing abilities of fetuses and discusses potential applications to adult wound healing, reporting no new experimental findings.
65 citations
,
December 2015 in “Experimental dermatology” This study found that both Th1 and Th2 immune responses, along with IL-23 and IL-32 cytokine pathways, are active in alopecia areata lesions, and corticosteroid injections significantly altered these immune markers.
58 citations
,
December 2000 in “Experimental Dermatology” This study found that new rabbit antisera against recombinant mouse involucrin effectively marked keratinocyte differentiation, with comparable expression patterns to human involucrin.
45 citations
,
April 2001 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that Myc superfamily transcription factors may have distinct roles in different epithelial compartments of the human hair follicle, possibly influencing cell fate in the putative stem cell compartment.
39 citations
,
November 2007 in “Experimental dermatology” This study found that prostaglandin receptors are widely expressed in hair follicles, suggesting a complex network of prostanoid pathways involved in hair growth control.
37 citations
,
August 2000 in “Journal of Cutaneous Pathology” This study found that keratin immunohistochemistry suggests neoplastic cells in eccrine and apocrine poromas are closely related to dermal sweat duct cells, but cannot differentiate these poromas based solely on keratin patterns.
35 citations
,
March 2012 in “Journal of dermatological science” This observational study aims to more accurately detect and localize Propionibacterium acnes in acne lesions by combining multiple microbiological visualization techniques, but it does not present new results on their causality to acne.
32 citations
,
December 2009 in “Archives of Dermatological Research” In this study, DHT was associated with increased production of proinflammatory cytokines IL-6 and TNF-α in cultured sebocytes, suggesting a role in acne pathophysiology beyond sebum production.
31 citations
,
June 2017 in “Regeneration” This study found that applying BMP2 stimulated limited regeneration of the amputated P2 bone in mice, but only when applied during a specific "regeneration window" after injury.
31 citations
,
November 2016 in “Cell Reports” This study reveals that somatosensory neurons in mouse skin exhibit structural plasticity during hair-follicle regeneration, which may temporarily impair the reliability of encoding gentle touch.
31 citations
,
January 2004 in “Methods in cell biology” Hair and follicle keratins differ in structure and expression, especially in cysteine content.
28 citations
,
March 2010 in “Histochemistry and Cell Biology” This study identified specific markers that can distinguish between stem cells in different regions of human scalp hair follicles, offering potential strategies for cell sorting and purification based on these markers.
28 citations
,
August 2006 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified that survivin is expressed in human hair follicles during their growth phase and its expression may be regulated by Wnt/β-catenin signaling, potentially influencing the balance between cell proliferation and apoptosis in hair follicle cycles.
28 citations
,
September 1995 in “Biochemistry and Cell Biology” This study localized Merkel cells in human skin, finding them in the basal layer of glabrous skin at palms and soles, and in the interfollicular epidermis and isthmus region of hair follicles.
24 citations
,
April 2017 in “Oncology Reports” In this study, full-size KRT81 was expressed in both normal breast epithelial and breast cancer cells, and contributed to the migration and invasion abilities of breast cancer cells.
24 citations
,
March 2001 in “Journal of Endocrinology/Journal of endocrinology” In this study, androgen receptors were found only in the mane follicles of red deer stags during the breeding season, suggesting their expression is induced by seasonal hormone changes.