June 2024 in “Research Square (Research Square)” This study demonstrated that in mice, the absence of Jagged-1 expression in skin-resident regulatory T cells significantly delays wound healing by reducing the accumulation of neutrophils, highlighting the role of Jagged-1 in coordinating immune cell recruitment during injury.
December 2022 in “Medical lasers” This study reviews the mechanism and potential treatment roles of low-level laser therapy for immune-mediated skin diseases, reporting no new clinical results.
December 2022 in “Journal of Pakistan Association of Dermatologists” This review highlights zinc's role in health and disease, noting its involvement in immune function and its therapeutic potential for conditions like alopecia areata and psoriasis, but it reports no new clinical results.
September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This study using a genetic mouse model found that S. aureus-driven dysbiosis sustains inflammatory skin side effects from EGFR inhibitors, suggesting prophylactic antibiotic treatment may reduce rash severity without fixing barrier defects.
January 2004 in “Weiliang yuansu yu jiankang yanjiu” This study found that diabetic individuals had significantly lower hair levels of chromium, manganese, and copper, but higher iron levels, compared to non-diabetic controls.
52 citations
,
September 2022 in “Viruses” This review discusses the functions of SARS-CoV-2 non-structural proteins in facilitating immune evasion and highlights possible therapeutic strategies, reporting no new clinical results.
47 citations
,
March 2019 in “Journal of immunology research” This review discusses the effects of valproic acid on immune cell activation and gene expression, potentially influencing infection outcomes and suggesting its promise for autoimmune and hypersensitivity condition management.
41 citations
,
February 2012 in “Journal of Neuroendocrinology” This study suggests that in late pregnancy, allopregnanolone induces opioid inhibition of oxytocin secretion in response to immune challenge, potentially minimizing the risk of preterm labor in rats.
39 citations
,
January 2015 in “International journal for parasitology/International Journal for Parasitology” This study found that Schistosoma mansoni cercariae stimulate epidermal keratinocytes in mice, initiating pro-inflammatory responses and barrier repair mechanisms akin to those in wound healing.
30 citations
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April 2007 in “Journal of Leukocyte Biology” This study found that anti-CD44 treatment inhibited leukocyte migration in alopecia areata and eczema, suggesting targeted therapies could enhance contact sensitizer treatment for alopecia areata.
26 citations
,
June 2024 in “Frontiers in Immunology” The authors discussed that SOCS1 and SOCS3's inhibition of JAKs plays a significant role in the development of JAK inhibitor drugs for skin inflammatory diseases and malignancies.
22 citations
,
January 2012 in “Mediators of inflammation” This review discusses the potential benefits of nonantibiotic macrolides for treating inflammatory skin disorders and reports no new clinical results.
17 citations
,
May 2019 in “BMJ Open” This review discusses the potential of drugs targeting the JAK/STAT pathway for dermatological diseases and outlines a protocol to assess existing evidence, reporting no new clinical results.
14 citations
,
March 2017 in “Genes and immunity” Certain microRNAs may help treat alopecia areata by targeting immune pathways.
11 citations
,
October 2023 in “ACS Pharmacology & Translational Science” This review discusses the potential of plant-derived natural compounds with immunomodulatory properties as novel antiviral therapies, highlighting their possible mechanisms against various viral infections in the context of traditional and biotechnological applications.
10 citations
,
May 2011 in “American Journal of Hematology” This study found that vinblastine treatment rapidly increased platelet counts in childhood refractory immune thrombocytopenia, providing effective control of bleeding symptoms, although side effects like neuropathic pain were common and resolved with dose adjustments.
9 citations
,
December 2022 in “Antibiotics” This study found that coconut seed extract may effectively treat scabies in rabbits by improving infection signs and causing high mite mortality, suggesting its potential as a cost-effective herbal alternative.
8 citations
,
October 2023 in “Frontiers in Immunology” This study explores the potential connection between circulating cytokines and immune skin diseases, offering insights that may enhance understanding of their causes, diagnosis, and treatment approaches.
5 citations
,
April 2019 in “Journal of Investigative Dermatology” This study found that oral JAK3 and TYK2/JAK1 inhibitors improved clinical outcomes in alopecia areata patients by reducing immune responses and enhancing hair keratin expression, with stronger effects in those with shorter disease duration.
2 citations
,
January 2024 in “European Journal of Case Reports in Internal Medicine” The researchers reported a case of Beau's lines in a 65-year-old man, potentially linked to past severe COVID-19 infections, suggesting that identifying these nail changes might signal prior infection and increased risk of reinfection.
1 citations
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April 2015 in “Cytokine” This study found that finasteride may improve pulmonary and hepatic immune responses in mice when administered after major trauma and hemorrhage.
July 2026 in “Journal of Investigative Dermatology” May 2026 in “Bioorganic Chemistry” March 2026 in “ACS Applied Materials & Interfaces” This study introduced an innovative nanozyme system called MCP@G, which was shown to improve diabetic wound healing in rats by alleviating mitochondrial oxidative stress, enhancing fibroblast migration, and promoting blood vessel and hair follicle regeneration, offering a promising approach for treating challenging diabetic wounds.
January 2026 in “Metabolites” This study analyzed gene expression profiles from multiple tissues to explore the molecular connections between obesity and immune-related processes, identifying potential links and pathways that may require further experimental validation to understand their roles in obesity fully.
January 2026 in “Advances in Clinical and Experimental Medicine” This paper proposes a model integrating regulatory T cells and mesenchymal stem/stromal cells to enhance understanding of peripheral immune tolerance, suggesting their combined roles in immune regulation, autoimmunity pathophysiology, and potential MSC-based therapies.
January 2026 in “Journal of Biomedical Research” This review discusses the potential of small extracellular vesicles (sEVs) as next-generation therapeutics, noting their ability to overcome biological barriers and modulate cellular environments for various diseases.
July 2025 in “Russian Journal of Clinical Dermatology and Venereology” In this case report, researchers observed that two sisters with congenital immune disorders experienced partial hair regrowth while receiving tofacitinib for severe alopecia areata, highlighting the need for careful clinical and laboratory monitoring due to potential infection risks associated with JAK inhibitor therapy.
May 2025 in “Experimental Dermatology” This study found that specific TRPM5 modulators are unlikely to directly affect sebaceous glands, but safe TPPO analogues may provide moderate lipogenic and anti-inflammatory effects beneficial for dry skin conditions.
August 2024 in “Journal of the Egyptian Womenʼs Dermatologic Society” In this observational study, SOX10 was expressed in 53 out of 81 examined hair follicles in patients with alopecia areata and showed a significant positive relation with the perifollicular lymphocytic infiltrate, suggesting that melanocytes may play a role in the disease's autoimmune pathogenesis.