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The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Probiotic bacteria improved skin and hair health in aged mice.

Alopecia areata is a chronic condition causing hair loss, with new treatments targeting the immune system showing promise.

Skin stem cells remember past inflammation, helping them respond better to future injuries and possibly aiding in treating skin issues.

GRK2 is essential for healthy hair follicle function, and its absence can lead to hair loss and cysts.

The cause of alopecia areata is likely a mix of genetics, immune system issues, and environmental factors, with more research needed to understand it fully.

T cells and bacteria in the gut and skin help maintain health and protect against disease.

The cause of Frontal fibrosing alopecia, a type of hair loss, is complex, likely involving immune responses and genetics, but is not fully understood.

IVIG therapy was linked to hair regrowth in two patients with hair loss, but it's not recommended due to its risks and costs.

CRH in the skin acts like the body's stress response system, affecting cell behavior and immune activity.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Understanding hair growth involves complex factors, and more research is needed to improve treatments for hair loss conditions.

Targeted immunotherapy could be a promising new treatment for hair regrowth.

Lichen Planus is a less common condition affecting skin and mucous membranes, with various types and associated risk factors, challenging to diagnose, significantly impacts life quality, and may have a risk of cancerous changes in oral lesions.

Understanding how hair follicle stem cells work can help find new ways to prevent hair loss and promote hair growth.

Changes in skin microbes play a role in some skin diseases and could lead to new treatments.

Inflammation plays a key role in activating skin stem cells for hair growth and wound healing, but more research is needed to understand how it directs cell behavior.

Bacteria in our hair can affect its health and growth, and studying these bacteria could help us understand hair diseases better.

Nitric oxide is important for skin functions and both helps protect against and contributes to skin inflammation and sensitization.

People with alopecia have a higher risk of thyroid cancer.

The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.

Type I interferons play a key role in the development of various skin diseases.

Some treatments like methotrexate with prednisone might help juvenile morphea, but more research is needed to confirm.

A mother and son both had ulcerative colitis and alopecia, suggesting a genetic link in autoimmune disorders and successful treatment with cyclosporine.

Immunosuppressive therapy helps manage autoimmune diseases but carries risks like infection and potential for malignancy.

The document concludes that corticosteroids effectively treat vasculitis allergica in over 90% of cases, with long-term kidney issues being the main adverse outcome.

A man developed neurological issues from SARS-CoV-2 without severe breathing problems, worsening to death.

The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.

The document concludes that hair loss is complex, affects many people, has limited treatments, and requires more research on its causes and psychological impact.

Different stem cells are key for hair growth and health, and understanding their regulation could help treat hair loss.