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This review summarizes the latest progress and challenges in skin organoid research, emphasizing advancements in organoid construction, applications in disease modeling, and factors affecting tissue maturation, while noting barriers such as vascularization and neural integration that hinder clinical translation.

In this study, 55 pediatric patients with hidradenitis suppurativa were assessed, revealing common comorbidities like obesity and acne, a frequent delay in diagnosis, and that most patients experienced symptom improvement with treatment including antibiotics and hormone therapy.

This article reviews the general, pathophysiological, diagnostic, and therapeutic aspects of alopecia frontal fibrosante, highlighting its irreversible nature and the importance of early diagnosis, but it reports no new clinical results.

In this case report, a 39-year-old man with sudden whitening of scalp hair due to alopecia areata experienced total regrowth of pigmented hair after six months without systemic treatment.

This review outlines treatment options for alopecia areata and highlights promising new therapies like targeted immune interventions and platelet-rich plasma application, but reports no new clinical results.

This diagnostic discussion reports that diffuse alopecia areata was identified in a patient with diffuse hair loss, based on specific histopathological features observed in a biopsy.

In this study, patients with systemic lupus erythematosus and generalized non-scarring alopecia exhibited hair loss similar to telogen effluvium, with significant changes observed in the cuticle of telogen hairs.

This case report describes the characteristic clinicopathological features of trichodysplasia spinulosa in two boys with acute lymphocytic leukemia, highlighting its resolution as immune function normalizes.

This review discusses the genetic, autoinflammatory, and keratinization factors involved in hidradenitis suppurativa and presents the concept of classifying it as an autoinflammatory keratinization disease, but reports no new clinical results.

This article reviews the potential role of prolactin as a neuroendocrine modulator in skin biology and pathology, discussing its relevance for conditions such as psoriasis and hair growth, but reports no new clinical findings.

This review examines the role of autoinflammation and immune dysregulation in hidradenitis suppurativa, linking it to genetic factors and autoinflammatory syndromes, but highlights the need for further research to fully understand its pathogenic mechanisms.

This study found that patients with hidradenitis suppurativa had significantly higher levels of cell-free DNA in their serum compared to healthy controls, suggesting its potential as a biomarker for the disease.

This article reviews possible pathogenesis scenarios for hidradenitis suppurativa and emphasizes the need for focused research on the innate immune system of hair follicles to better understand the disease.

This review explores the complex causes and treatment options for alopecia, emphasizing that current therapies mainly offer symptomatic relief, while new advancements like stem cell approaches and improved drug delivery systems show promise for addressing underlying disease mechanisms.

This review highlights that alopecia's complex causes include hormonal, genetic, and environmental factors, and discusses traditional and emerging therapies, suggesting a need for multi-targeted, mechanism-based treatments to improve long-term management and efficacy.

This source discusses how the skin mycobiome, dominated by Malassezia fungi, may provide a unique niche that can be disrupted by environmental changes, potentially leading to the fungal pathogen C. auris overtaking Malassezia and predisposing individuals to severe infections.

This study found that the systemic immune-inflammation index (SII) can be used as a cost-effective marker to assess the severity and treatment response in patients with alopecia areata.

This study found that patients with severe acne vulgaris had different systemic inflammatory indices and hematologic parameters compared to healthy individuals.

This Delphi study found that moderate-to-severe alopecia areata in Poland, Czechia, Russia, and Türkiye significantly impacts quality of life and highlights an unmet need for more effective treatments.

This study found that inducing a leaky gut in mice led to increased gut permeability and decreased expression of protective genes, suggesting a potential link to alopecia areata.

This study found that blood cell count derived parameters were similar across non-cicatricial alopecia groups but showed general differences when compared to psoriasis and hidradenitis suppurativa. Among patients with alopecia areata, modulating platelet number and volume may serve as a therapeutic marker.

This review summarizes existing literature on the safety of commonly used dermatologic medications during pregnancy but does not present new clinical findings, aiming to assist physicians with prescribing decisions.

This review explores the potential of neuro-driven hydrogels for skin and nerve regeneration, integrating biochemical cues and advanced technologies like AI for personalized wound healing, but notes the need for further validation and trials before clinical use.

The researchers reported that integrating the naturopathic complex Detoxil into standard therapy for chronic dermatoses enhances detoxification, normalizes metabolic markers, and accelerates symptom resolution, suggesting potential benefits for managing skin conditions.

This article discusses the role of neurohormones and neuropeptides in hair follicle pigmentation and outlines promising neuroendocrinological strategies to address greying and damage, but reports no new clinical results.

Vitiligo is caused by the immune system attacking skin pigment cells.

Alopecia areata is linked to immune system differences, with specific biomarkers like CXCL9 and CXCL10 being key for diagnosis and potential treatment targets.

This study found that systemic administration of NDP-MSH, a melanocortin receptor agonist, provided neuroprotective effects on dopaminergic nigrostriatal neurons in a mouse model of Parkinson's disease, reducing neuroinflammation and suggesting a role for regulatory T cells in these neuroprotective effects.

This review discusses the dermatological effects and potential mechanisms of plant adaptogens, emphasizing their role in skin health and aging without presenting new experimental results.

Too much zinc can cause hair loss and weaken the immune system.