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This case report describes a rare association where herpes zoster infection may have triggered the first attack of NMOSD with systemic vasculitis in a patient, suggesting potential overlaps in immunopathogenesis.

This study found that in mice, perforin-mediated cytolysis by CD8 T cells is not necessary for the autoimmune attack on hair follicles in alopecia areata, suggesting other mechanisms are responsible for disease progression.

This paper identifies challenges in diagnosing alopecia variants, emphasizing the importance of pathologists understanding hair follicle histology, biopsy types, and collaborating with dermatologists to improve diagnostic accuracy.

In this study, a mouse model of scarring alopecia demonstrated significantly reduced CD200R expression in affected skin, which may contribute to immune attacks on hair follicles.

This case report describes an 11-year-old Lhasa Apso diagnosed with hypothyroidism and diabetes mellitus, illustrating the link between these common endocrine disorders in dogs.

This review discusses how modern lifestyle factors affecting gut health may contribute to Alopecia Areata in genetically predisposed individuals, reporting no new results but suggesting the need for long-term interventions.

In this study, researchers found that in mice, gonadal hormones and biological sex do not affect the expression of SARS-CoV-2 entry proteins ACE-2 and TMPRSS-2 in the respiratory tract, regardless of disease state.

In this review, researchers conclude that immune imbalance between regulatory and cytotoxic T cells, along with activation of IFN-γ–MHC and IL-15–NK pathways, disrupts hair follicle immune privilege, suggesting pivotal mechanisms in alopecia areata development and potential targets for immunotherapeutic interventions.

This study reported that CXCL12 may have a dual role in alopecia areata, where decreased levels could impair angiogenesis and disrupt vascular support to hair follicles, while its overexpression might exacerbate autoimmune attacks on hair follicles, contributing to hair loss.

Vitiligo is caused by the immune system attacking skin pigment cells.

This study reported that newly developed RADA16-I peptide hybrids, with active motifs like GHK and KGHK, demonstrated improved wound healing in a mouse skin injury model without cytotoxicity, suggesting they might be effective scaffolds for tissue engineering and regeneration.

This article discusses the challenges in diagnosing and treating autoimmune diseases, emphasizing the need for regenerative medicine approaches to address the root causes rather than just suppressing symptoms.

This article discusses autoimmune diseases, detailing their types, symptoms, and potential management strategies, without providing new clinical findings.

This article discusses various autoimmune diseases, including their symptoms and management, and reports no new clinical findings.

This abstract discusses alopecia areata, highlighting its complex autoimmune pathogenesis involving immune cells and signaling molecules, and underscores the importance of accurate diagnosis and tailored management strategies, noting the need for further research to improve treatments.

This study found that direct immunofluorescence of hair is a simple and non-invasive alternative for monitoring pemphigus vulgaris, matching skin biopsy results in the cases observed.

This review provides an overview of genetics, causes, and treatment options for alopecia areata but reports no new clinical results and emphasizes the importance of support for those affected.

This study demonstrated that both classical and atypical BSE strains from cattle can be transmitted to goats, highlighting the importance of surveillance in protecting public health.

This review discusses alopecia areata as a model for studying tissue-directed autoimmune diseases and reports no new clinical findings.

This review discusses the complex interplay of factors controlling hair regeneration and highlights the potential for targeted clinical applications in various hair disorders, while reporting no new clinical results.

This abstract outlines the issue of hair loss caused by various factors, including stress and autoimmune disorders like alopecia areata, which results in spot baldness, but does not provide specific study results.

This research reported that the FDA approved Litfulo® (ritlecitinib) as the first oral treatment for severe alopecia areata in adolescents over 12 years old, with 23% of treated patients showing significant hair regrowth in clinical trials compared to 1.6% with placebo.

This abstract provides background information on alopecia areata, describing it as an autoimmune condition leading to non-scarring, patchy hair loss but does not report specific study results.

This review discusses the pathogenesis of alopecia areata, highlighting the role of immune privilege collapse in hair follicles but reports no clinical results.

This review discusses the interplay between hormonal and immune systems in hair follicles and reports no new results, highlighting the need for further research on their role in skin biology and alopecia areata.

A man was diagnosed with a rare form of lupus after showing unique skin symptoms that responded well to treatment.

This study found that alopecia areata is linked to genetic factors, specifically HLA haplotypes on chromosome 6, and involves immune privilege collapse at hair follicles which is mediated by the JAK-STAT pathway and pro-inflammatory cytokines like IFN-γ.

This study describes previously unknown immune characteristics of the normal human nail, highlighting its similarities to the hair follicle immune system and suggesting an immune privilege in the proximal nail matrix that both provides autoimmunity protection and presents infection susceptibility.

The researchers designed a Janus microneedle system for treating vitiligo, which targets the skin’s layers to regulate the immune response, promote melanocyte regeneration, and enhance pigment transfer, offering a new precise treatment approach for this condition.

Permanent hair loss after a stem cell transplant can be a sign of chronic immune system attack on the scalp.