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This study found that sulfated CCK octapeptide reduces psoriasis-like skin inflammation in mice, suggesting a new pathophysiological role for CCK in regulating epidermal inflammation.

People with acne have more CD4+ immune cells in their skin than healthy people.

This review discusses immune pathways involved in alopecia areata and explores emerging, more targeted therapeutic strategies, noting their potential for better safety and effectiveness compared to traditional immune suppressants.

This study found that nanobubble-encapsulated diclofenac with ultrasound-targeted microbubble destruction (DNBs-UTMD) can enhance the anti-tumor efficacy of Doxil® by regulating the tumor immune microenvironment, improving drug uptake, and increasing T cell responses while reducing immune-suppressive cells in the process.

This article reviews the roles and synthesis of essential long-chain fatty acids in the body and reports no new research findings; it emphasizes the importance of dietary sources for these lipids.

This study tested a hydrogel microneedle patch delivering T reg attractants in mice with alopecia, finding it boosted regulatory T cell numbers at the site, leading to hair regrowth without causing peripheral immunosuppression, suggesting a potential new approach for autoimmune skin disease treatment.

In this study, researchers developed a dissolvable microneedle patch combining HA-TEMPO and Portulaca oleracea L.-derived nanoparticles, which effectively reduced oxidative stress and inflammation in an atopic dermatitis model while restoring immune balance, suggesting a promising treatment strategy.

A heart transplant patient developed a skin condition called epidermodysplasia verruciformis after taking immune-suppressing drugs.

This case report describes the first known recovery from alopecia universalis using standard immunosuppression after lung transplantation in a patient with advanced bronchiectasis.

This review discusses the relationship between aging, chronic inflammation, and immunosuppression, suggesting that these interconnected processes may contribute to tumorigenesis and premature aging, but reports no new experimental results.

This research found that topical minoxidil may promote hair regrowth in alopecia areata by stimulating hair follicle epithelium and suppressing certain immune responses, with potential contributions from its vasodilatory effects.

This review discusses the preclinical and clinical data on teriflunomide for multiple sclerosis, highlighting its selective action on immune cells without causing clinical immune suppression, and provides no new clinical results.

This article reviews the roles of lesser-known secreted phospholipase A2 isoforms in various biological processes, such as immune suppression, metabolic regulation, epidermal hyperplasia, and male reproduction, without reporting new clinical findings.

This case report describes a rare instance of tuberculous lymphadenitis in a patient with systemic lupus erythematosus, highlighting the potential link between immune suppression and tuberculosis risk.

This report details a case of tuberculous lymphadenitis in a 21-year-old female with SLE, suggesting that immune suppression may increase susceptibility to this extra-pulmonary TB.

This study found that theabrownin-selenium nanoparticles (TB-Se NPs) effectively target Malassezia-induced dermatitis through a dual antifungal and immunomodulatory mechanism, suppressing fungal overgrowth, reducing inflammation, and enhancing immune memory to prevent recurrence in a dermatitis model.

This case study describes a 4-year-old boy with juvenile dermatomyositis whose severe subcutaneous edema resisted conventional treatment, necessitating aggressive immunosuppression for disease control.

This case report describes a 70-year-old kidney transplant recipient who developed a keratoacanthoma near an arteriovenous fistula after returning to hemodialysis and stopping immunosuppression.

This case report describes a 30-year-old woman with vitiligo who developed a rare dermatophyte infection encircling one of her vitiligo patches, possibly due to immunosuppression from her treatment.

This study retrospectively analyzed 945 patients with head and neck cSCC to identify risk factors for recurrences, reporting treatment modality, tumor characteristics, and patient factors such as immunosuppression as strong predictors for loco-regional recurrences.

This study found that Cyclosporin A may prolong the anagen phase of hair growth in cultured dermal papilla cells by decreasing TGF-β2 expression, similar to its mechanism in immunosuppression.

Immune cells called Treg cells are essential for hair growth and regeneration.

This review summarizes the pathophysiology and immune mechanisms of inflammatory skin diseases like psoriasis and atopic dermatitis, highlighting the therapeutic potential of targeted immunotherapies, but reports no new clinical results.

This review discusses the heterogeneity of Tregs in normal and tumor environments, emphasizing the complexity of targeting tumor-resident Tregs while maintaining systemic immune tolerance, but reports no new findings.

This study investigated immune dysregulation in individuals with Down syndrome and found that treatment with the JAK inhibitor tofacitinib improved skin conditions like alopecia areata and reduced autoimmune markers without severe side effects. Additional research is necessary to understand its broader impacts.

This review discusses sex differences in immune responses and highlights mechanisms involving sex hormones, X-linked genes, and X-Chromosome Inactivation, but reports no new clinical findings.

In this study, IFN-γ-stimulated iPSC-derived mesenchymal stem cell extracellular vesicles improved atopic dermatitis in mice by reducing Th2 cytokine activity, suppressing inflammation, and restoring skin barrier function, as evidenced by decreased itching and inflammatory markers.

This review discusses the potential immuno-regenerative effects of polydioxanone threads in hair loss treatment, focusing on tissue responses and immune modulation, but does not report clinical results.

This study observed that individuals with Down syndrome exhibit early immune dysregulation, including multi-organ autoimmunity and hypercytokinemia, and found that the JAK inhibitor tofacitinib showed a good safety profile and reduced skin pathology in a Phase II trial.

This study found that in mice with premature ovarian insufficiency, miR-21 enhances ovarian function recovery following umbilical cord-derived mesenchymal stem cell transplantation by influencing specific cellular signaling and immune pathways.