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The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Stress can cause hair loss by negatively affecting hair follicles and this effect might be reversed with specific treatments.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

The document concludes that hair is complex, with a detailed growth cycle, structure, and clinical importance, affecting various scientific and medical fields.

Certain immune cells in the skin release a protein that stops hair growth by keeping hair stem cells inactive.

Mammals might fail to regenerate not because they lack the right cells, but because of how cells respond to their surroundings, and changing this environment could enhance regeneration.

Animal models have helped understand hair loss from alopecia areata and find new treatments.

Lichen Planopilaris and Frontal Fibrosing Alopecia may help us understand hair follicle stem cell disorders and suggest new treatments.

Fat tissue cells are a promising option for healing various diseases, but more research is needed to ensure they are safe and effective.

Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.

Using CRISPR for gene editing in the body is promising but needs better delivery methods to be more efficient and specific.

Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.

The conclusion is that individual differences in COVID-19 severity are influenced by factors like age, sex, race, and genetics, which are important for personalized medicine.

The document concludes that while there are various treatments for Alopecia Areata, there is no cure, and individualized treatment plans are essential due to varying effectiveness.

The review suggests that other immune cells besides CD8+ T cells may contribute to alopecia areata and that targeting regulatory cell defects could improve treatment.

New methods to improve the healing abilities of mesenchymal stem cells for disease treatment are promising but need more research.

RANK is a key target in breast cancer treatment due to its role in tumor growth and bone metastasis.

RXRα is crucial for proper immune response and links diet to immune function.

Lysophospholipids like LPA and S1P are important for hair growth, immune responses, and vascular development, and could be targeted for treating diseases.

Wounds on the face usually heal with scars, but understanding how some wounds heal without scars could lead to better treatments.

Cytokines and neuropeptides are key in controlling androgen levels, affecting skin and hair conditions.

The document concludes that future heart disease research should account for sex-specific differences to improve diagnosis, treatment, and outcomes.

Fat cells are important for tissue repair and stem cell support in various body parts.

MicroRNAs play a crucial role in skin and hair health, affecting everything from growth to aging, and could potentially be used in treating skin diseases.

Blocking JAK/STAT pathways can help treat hair loss from alopecia areata.

Aging slows wound healing due to weaker cells and immune response.

Tiny particles called extracellular vesicles could help with skin healing and hair growth, but more research is needed.

Skin and hair can help us understand organ regeneration, especially how certain stem cells might be used to form new organs.