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Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

Stress-related substance P may lead to hair loss and negatively affect hair growth.

Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.

Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

No single treatment is consistently effective for alopecia areata, and more research is needed.

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

Folliculitis decalvans is a rare scalp condition causing scarring hair loss, treated with long-term antibiotics and other medications, but it often comes back and is hard to manage.

Oral retinoids are effective for various skin conditions but have side effects and should not be used during pregnancy.

Alopecia areata is caused by immune system attacks on hair follicles, often triggered by viral infections.

Skin surface lipids are important for skin health and altering them could help prevent aging and treat skin conditions.

Fullerenes show potential in skin care but need more safety research.

Hair follicles help skin immune recovery after UVB exposure.

Melanocytes are crucial for skin pigmentation and can affect conditions like melanoma, vitiligo, and albinism, as well as hair color and hearing.

The circadian clock is crucial for tissue renewal and regeneration, affecting stem cell functions and having implications for health and disease.

FOXO1 is important for wound healing, but its dysfunction in diabetes can slow the healing process.

Alpha-hydroxy acids, like glycolic acid, safely improve skin issues and work on all skin types.

Animal models have helped understand hair loss from alopecia areata and find new treatments.

The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.

Children with atopic dermatitis often have sleep problems due to itching and may benefit from melatonin, which helps with sleep and skin symptoms.

Using CRISPR for gene editing in the body is promising but needs better delivery methods to be more efficient and specific.

Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.

Environmental factors at different levels control hair stem cell activity, which could lead to new hair growth and alopecia treatments.

The review suggests that other immune cells besides CD8+ T cells may contribute to alopecia areata and that targeting regulatory cell defects could improve treatment.

Vitamin A affects hair loss and immune response in alopecia areata.

New methods to improve the healing abilities of mesenchymal stem cells for disease treatment are promising but need more research.

Some skin conditions may indicate metabolic syndrome, which could help with early detection and management of related health issues.

RANK is a key target in breast cancer treatment due to its role in tumor growth and bone metastasis.