19 citations,
December 2016 in “The journal of pharmacology and experimental therapeutics/The Journal of pharmacology and experimental therapeutics” Certain drugs increase calcium levels in cancer cells by triggering internal calcium release.
13 citations,
April 2022 in “Frontiers in oncology” Melanoma development can be linked to the breakdown of skin's melanin-producing units.
5 citations,
October 2020 in “Brain Research Bulletin” Etifoxine, an anxiety drug, can lessen brain inflammation and cognitive issues in mice, partly by increasing production of protective brain steroids.
4 citations,
October 2013 in “Springer eBooks” Melatonin receptors, found in many body parts, can help treat various diseases like depression and diabetes due to their effects on inflammation, tumor progression, sleep disorders, and body mass regulation.
2 citations,
December 2022 in “PNAS nexus” SCD-153 shows promise as an effective topical treatment for alopecia areata.
2 citations,
July 2019 in “Journal of psychology & clinical psychiatry” Zinc helps reduce the severity of depression.
1 citations,
July 2016 in “Elsevier eBooks” Understanding skin structure and development helps diagnose and treat skin disorders.
Tacrolimus causes fewer acute rejections than cyclosporin A in kidney transplants but doesn't necessarily improve kidney function after one year; cardiovascular risks and side effects vary between the two drugs.
237 citations,
February 2016 in “Science Translational Medicine” The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.
176 citations,
January 2003 in “Journal of Investigative Dermatology” Bone Morphogenetic Proteins (BMPs) help control skin health, hair growth, and color, and could potentially be used to treat skin and hair disorders.
144 citations,
August 2019 in “Cells” The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.
140 citations,
April 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” The enzyme 25 Hydroxyvitamin D 1 α-Hydroxylase is essential for healthy skin and recovery after skin damage.
112 citations,
May 2019 in “Pharmacological Research” Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.
77 citations,
January 1989 in “Clinical Infectious Diseases” Toxic Shock Syndrome progresses quickly, often involves multiple organs, and is linked to Staphylococcus aureus toxins, with treatment options available but diagnostic challenges remaining.
57 citations,
June 2021 in “Polymers” Photothermal hydrogels are promising for infection control and tissue repair, and combining them with other treatments could improve results and lower costs.
48 citations,
February 2013 in “Molecular and Cellular Endocrinology” The protein StAR is found in 17 different organs and can affect hair loss and brain functions, but its full role is not yet fully understood.
43 citations,
August 2016 in “International Journal of Nanomedicine” Eupafolin nanoparticles help protect skin cells from damage caused by air pollution.
28 citations,
January 2021 in “Parkinsonism & related disorders (Online)/Parkinsonism & related disorders” Parkinson's disease is linked to skin disorders and skin cells help in studying the disease.
28 citations,
March 2017 in “Endocrinology” Removing vitamin D and calcium receptors in mice skin cells slows down skin wound healing.
16 citations,
February 2018 in “BMC Genomics” Certain genetic markers linked to reproductive potential were identified by their impact on a protein's ability to bind to genes.
11 citations,
August 2018 in “Facial Plastic Surgery Clinics of North America” Adipose-derived stem cells show potential for skin rejuvenation and wound healing but require more research to overcome challenges and ensure safety.
11 citations,
October 2017 in “Journal of Investigative Dermatology” Applying certain inhibitors to the skin can promote hair growth without harming cells.
3 citations,
January 2012 in “Elsevier eBooks” Burn scars form abnormally due to changes in wound healing, and more research is needed to improve treatments.
2 citations,
October 2010 in “Reviews in Medical Microbiology” Syphilis is becoming more common and remains a major health problem due to challenges in prevention and treatment.
1 citations,
October 1996 in “Journal of Cutaneous Medicine and Surgery” Gene therapy shows promise for treating skin disorders and cancer, but faces technical challenges.
May 2023 in “Animal Reproduction Update” High levels of cortisol in hair show long-term stress which can lower fertility in animals.
September 2020 in “Research Square (Research Square)” Certain genes influence immunoglobulin levels in Chinese Holstein cows, which can improve calf health.
January 2003 in “Elsevier eBooks” Androgens and other hormones affect hair growth and skin conditions like acne.
140 citations,
December 2017 in “Journal of Controlled Release” Microneedles improve drug delivery in various body parts, are safe and painless, and show promise in cosmetology, vaccination, insulin delivery, and other medical applications.
155 citations,
August 1991 in “Journal of The American Academy of Dermatology” Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.