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In this study, fibroblasts from long-term skin biopsy cultures retained their ability to reprogram into induced pluripotent stem cells after 16 months, despite undergoing transcriptional changes and decreased proliferation rates over successive generations.

This study developed and validated an optimized culture method for dermal papilla cells, leading to the establishment of an immortalized cell strain called iDP6, which resembles primary DP cells in key characteristics.

This study found that Muse cells retained their pluripotency and ability to differentiate into various cell types even after being cryopreserved multiple times.

In this study, DPC-hTERT cells were shown to induce hair follicle-like structures expressing specific keratin when co-injected with epithelial cells into nude mice.

This research discusses the shift in cosmetic dermatology towards integrating regenerative medicine, AI, and personalized care, highlighting their potential to improve aesthetic outcomes and skin function while considering ethical and regulatory challenges.

This study concluded that the process of mummification disfigures facial features, making identification challenging, but commercial shrunken heads retain more defining features compared to ceremonial ones.

Bioengineered skin models aging well, useful for studying aging and testing treatments.

This research found that immobilizing type I atelocollagen onto artificial hair significantly improved the adhesion and long-term fixation of the hairs in the human scalp, indicating high biosafety and enhanced tissue integration.

This study reports that microencapsulation of therapeutic cells with contrast agents enables visualization across multiple imaging modalities, potentially improving cellular immunoprotection and tracking after transplantation.

This study introduces a new multimodal imaging technology to visualize and quantify cell dynamics in natural skin over long durations, demonstrated in GFP bone marrow-transplanted mice, to study dynamic skin regeneration.

In this study, isolated human hair follicles maintained prolonged growth and consistent DNA and keratin synthesis patterns in a fully defined medium for at least 9 days while preserving in vivo-like morphology.

This article describes the immunofluorescence tomography method to achieve high-resolution 3-D reconstruction of epithelial tissues and reports no clinical results.

This study found that preserving hair micrografts in an enriched storage medium for five hours significantly increased their survival rate compared to those stored in saline.

This research outlines an innovative bioregeneration chamber aimed at significantly extending human lifespan and enhancing health maintenance by treating the body as a thermodynamic system, potentially enabling an average lifespan of 130 to 150 years in an advanced therapeutic setting.

In this study, researchers showed that multiphoton microscopy with fluorescent protein tagging enables single-cell imaging and tracking in live transgenic mice, offering new insights into cell dynamics in stem cell research compared to traditional histological methods.

This study reported that an ex vivo organ culture system effectively induced aging-related changes in healthy human skin, allowing testing of senolytics like tretinoin, resveratrol, and caffeine.

This review examines the process of cornification as a mode of programmed cell death and outlines how keratinocytes activate anti-cell death mechanisms to maintain epidermal homeostasis, but reports no new results.

This review highlights how in vivo imaging can explore biological processes related to stem cell activity, behavior, and control, but it reports no new clinical results.

In this study, an immortalized MSC line from human adipose tissue showed potential for applications in regenerative medicine and inflammatory diseases through production of active factors, demonstrated in vitro.

This study found that permanent makeup pigments were applied at similar depths as traditional tattoo inks in mice but faded over time due to larger inorganic pigments.

This study proposes a model describing the transformation process from living to dead cells during early hair formation, highlighting the stepwise degradation of cellular functions.

This study found that storing hair follicle grafts in chilled ATPv-supplemented saline was most effective for preserving trichogenic gene expression, compared to other storage solutions and temperatures.

This study presents a new long-term 3D skin model using cells from mature donor skin, showing significant features of skin aging, such as decreased cellular proliferation and hyaluronan content.

This study established that cryopreservation methods can maintain the pluripotency and hair growth potential of hair follicle-associated pluripotent stem cells, enabling potential applications in regenerative medicine and hair transplantation.

This study found that stem cells can temporarily act as non-professional phagocytes during hair cycle regeneration by clearing apoptotic cells through a process requiring local lipids and retinoids for activation, providing insights into their dual role in maintaining tissue integrity.

This study found that storing hair micrografts in DMEM with apoptotic cell death inhibitors improved in vitro hair shaft elongation and reduced apoptosis, potentially enhancing micrograft transplantation outcomes.

In this study published in Nature, researchers explored how hair follicle stem cells manage apoptotic cell clearance while maintaining their regenerative roles, identifying significant molecules involved in sensing and engulfing dying cells to sustain tissue health.

This article discusses the potential impact of biomedical innovations in aging biology on extending human lifespan and highlights both the pharmaceutical industry's investment in such innovations and the potential implications for pension systems, reporting no new results.