44 citations
,
March 2016 in “Frontiers in cellular neuroscience” In this study using zebrafish, four bisbenzylisoquinoline derivatives were found to protect hair cells from aminoglycoside-induced damage without reducing antibiotic efficacy, potentially leading to therapies for patients undergoing such treatments.
43 citations
,
April 2021 in “Angiogenesis” This review examines the evolving understanding of lymphatic vessel development, emphasizing new cellular mechanisms and lineage diversity, while discussing experimental methods and identifying key knowledge gaps.
43 citations
,
July 2019 in “Stem Cells International” This review discusses advances and challenges in skin tissue engineering, focusing on developing 3D constructs for functional skin substitutes, and reports no new clinical results.
43 citations
,
August 2018 in “Cell Stem Cell” This study found that Hoxc gene expression can reprogram mesenchymal dermal papilla cells, enhance epithelial stem cell regenerative potential, and promote region-specific hair follicle regeneration through Wnt signaling.
43 citations
,
December 2013 in “Stem Cells” Stretching skin increases a certain protein that attracts stem cells, helping skin regeneration.
43 citations
,
March 2009 in “Journal of Cellular and Molecular Medicine” This study suggests that TGF-β 2 plays a critical role in hair follicle morphogenesis and may enhance the effectiveness of future cell therapies for hair regrowth using expanded dermal papilla cells.
42 citations
,
September 2017 in “Advances in protein chemistry and structural biology” This chapter reviews surface plasmon resonance (SPR) methodology and its applications in basic science and human disease without reporting new clinical results.
42 citations
,
January 2017 in “Stem cells international” This study found that while extracellular matrix components like hyaluronic acid promoted larger organoid formation, other matrix components hindered hair follicle germ assembly in an in vitro model.
42 citations
,
July 2014 in “Journal of biological chemistry/The Journal of biological chemistry” This study suggests that heparan sulfate is crucial for regulating hair follicle formation, cycling, and gland morphogenesis, with its ablation leading to continuous hair growth and increased gland activity in mice.
42 citations
,
March 2014 in “European Journal of Pharmacology” This study found that minor ginseng saponin F2 may promote hair growth more effectively than finasteride by enhancing anagen induction and modulating the Wnt signaling pathway in cell and mouse models.
41 citations
,
October 2024 in “Nature Communications” In this study, researchers developed a wearable red and blue LED patch and a sprayable fibrin gel to treat infected wounds at home, demonstrating effective infection control and enhanced wound healing in diabetic mice and minipigs.
41 citations
,
June 2018 in “Journal of The American Academy of Dermatology” This study examined the therapeutic response to folliculitis decalvans treatments among 60 patients and found that earlier disease onset was linked to more severe cases, while a combination of rifampicin, clindamycin, tetracyclines, and intralesional steroids was most effective in controlling symptoms.
41 citations
,
December 2015 in “Journal of the European Academy of Dermatology and Venereology” This review discusses the challenges and potential solutions in studying Demodex mites and their possible pathogenic role in human skin disorders but reports no new findings.
41 citations
,
July 2002 in “Clinical and Experimental Dermatology” This review evaluates hair growth measurement methods for human scalp hair, suggesting that combining highly resolutive analytical approaches with global calibrated methods is recommended for assessing hair changes in clinical settings.
41 citations
,
March 1998 in “Archives of Dermatological Research” This study found that androgen metabolism within hair follicles varies significantly between compartments, with dermal papillae showing high 5α-reductase activity, suggesting a key role in androgen-driven hair growth responses.
40 citations
,
November 2021 in “npj Regenerative Medicine” In this study, spiny mice showed superior cardiac recovery after myocardial infarction compared to other mouse strains, with enhanced myocardial preservation and functional stabilization.
40 citations
,
January 2016 in “PLoS ONE” The study found that exposing Arbas Cashmere goats to a short photoperiod significantly increased cashmere production by extending the anagen phase of hair follicles, with gene expression changes identified as contributing factors.
40 citations
,
May 2014 in “PLoS ONE” This study suggests that chronic stress can lead to decreased skin pigmentation in mice by disrupting the skin's HPA axis, potentially making stress a risk factor for depigmentation.
40 citations
,
June 2013 in “Biomaterials” This study developed a 3D engineered hair follicle model that mimics the native hair bulb and may aid in drug screening for hair growth therapies.
40 citations
,
June 2011 in “Journal of biological chemistry/The Journal of biological chemistry” This study revealed that deficiency in the enzyme FA2H in mice affected sebaceous gland function, altered sebum composition, and caused cycling alopecia, highlighting FA2H's role in hair follicle homeostasis.
39 citations
,
January 2019 in “The World Journal of Men's Health” Testosterone replacement therapy can prevent men from fathering children and should not be used by those wanting to stay fertile.
39 citations
,
October 2013 in “Plastic and Reconstructive Surgery” In this study, researchers found that intestine-derived human alpha defensin 5 enhances wound healing, reduces bacterial load, and promotes hair growth in murine burn wound beds by increasing LGR stem cell migration.
38 citations
,
June 2018 in “Plant & cell physiology/Plant and cell physiology” This study found that overexpressing PLC5 in Arabidopsis thaliana reduced root growth but improved drought tolerance, and suggests PIP2 is crucial for root hair growth.
38 citations
,
February 2016 in “Surgery Journal” This article discusses a wide range of procedures in facial plastic surgery and highlights the recent advancements and trends without reporting new clinical findings.
38 citations
,
October 2011 in “Analytical biochemistry” This study used proteomic techniques to analyze human hair proteins, revealing keratin heterogeneity and identifying posttranslational modifications, such as cysteine trioxidation and methylation.
37 citations
,
December 2024 in “Theranostics” In this study, a newly developed nanoparticle-loaded hydrogel wound dressing demonstrated significant antibacterial, antioxidant, anti-inflammatory, and proangiogenic activities, effectively reducing pain and promoting healing in a murine burn wound model while preventing infection by *Staphylococcus aureus*.
37 citations
,
April 2017 in “npj Regenerative Medicine” This study found that platelet-derived growth factor signaling is crucial for maintaining the hair follicle dermal stem cell pool and supporting their regenerative capacity.
37 citations
,
August 2014 in “Journal of experimental botany” This study identified the AtPRPL1 gene in Arabidopsis thaliana as being involved in cell elongation processes, despite unclear changes in cell wall composition from its altered expression.
37 citations
,
March 2010 in “British Journal of Dermatology” Oestrogen and thyrotropin-releasing hormone affect prolactin and its receptor in human skin and hair, suggesting new treatment options for related conditions.
36 citations
,
January 2019 in “Nature communications” This study found that Ldh activity in hair follicle stem cell-mediated squamous cell carcinoma is not necessary for tumorigenesis, as its modulation did not affect the cancer's development or characteristics.