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Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

The document concludes that the understanding of scar formation is incomplete and current prevention and treatment for hypertrophic scars and keloids are not fully effective.

Lichen Planus is a less common condition affecting skin and mucous membranes, with various types and associated risk factors, challenging to diagnose, significantly impacts life quality, and may have a risk of cancerous changes in oral lesions.

Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.

The guidelines suggest a detailed approach to diagnosing and treating lupus, with a focus on regular check-ups, personalized medicine, and a range of drug options for different cases.

Interferon alfa-2a is effective for treating cutaneous T cell lymphoma but has significant side effects.

Some herbal therapies may help with skin conditions, but more research is needed to confirm their safety and effectiveness.

Regulatory T-cells are important for healing and regenerating tissues in various organs by controlling immune responses and aiding stem cells.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

New effective scar treatments are urgently needed due to the current options' limited success.

COVID-19 can cause different skin symptoms that may help with early diagnosis and show how severe the disease is.

Isotretinoin is highly effective in treating severe acne, rosacea, and gram-negative folliculitis.

Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.

Low-Level Laser Therapy is effective and safe for hair growth with minimal side effects.

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

Blocking JAK-STAT signaling can lead to hair growth.

Some skin medications are safe during pregnancy and breastfeeding, but others can harm the baby and should be avoided.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Humans lost body hair relatively recently in evolution.

Liposomal systems show promise for delivering drugs through the skin but face challenges like high costs and stability issues.

Most people with systemic lupus erythematosus have skin problems, and skin symptoms are often the first sign of the disease.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

Aging causes skin stem cells to work less effectively.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Postpartum depression is linked to changes in brain chemicals, inflammation, stress, and certain genes, and can potentially be identified by markers like specific steroids, serotonin levels, and vitamin D levels.

Some viruses can cause cancer by changing cell processes and avoiding the immune system; vaccines and targeted treatments help reduce these cancers.

Taxane chemotherapy can cause skin, hair, and nail side effects, which are often under-reported and can affect patient quality of life.