Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review highlights the possible role of T regulatory cells in the immune-related mechanisms of alopecia areata but reports no new clinical findings.

This review suggests that IL-23 inhibitors may be effective for various non-psoriatic inflammatory skin conditions, but emphasizes the need for further large-scale trials to confirm their efficacy and safety.

This review covers presentations from the 68th Annual Meeting of the Society of Investigative Dermatology and highlights research advances in dermatology, but reports no new clinical results.

In a proof-of-concept study at Xiangya Hospital, the researchers observed that combining tofacitinib with low-dose interleukin-2 helped maintain remission in refractory alopecia areata patients, with three out of four maintaining complete remission for 11–20 months post-treatment and no adverse events reported.

This study found that topical ginsenoside Rg1 may protect skin from UVB-induced damage in mice by reducing pathological changes and modulating cytokine mRNA expression associated with inflammation and immune response.

This study describes a patient with metastatic renal cell carcinoma who experienced a recurrence of pemphigus vulgaris after receiving interleukin 2 immunotherapy, suggesting a possible link between the treatment and autoimmune disease recurrence.

In this study, hair-follicle-associated pluripotent stem cell implantation improved functional recovery and reduced inflammation in a mouse model of intracerebral hemorrhage.

This report describes two cases where patients developed alopecia while undergoing treatment for psoriasis with IL-17 inhibitors, suggesting an unexpected paradoxical reaction.

This case report describes a patient with psoriasis who experienced scalp hair darkening and increased growth during anti–IL-17 therapy.

This study found that patients with alopecia areata receiving combined therapy showed a significant reduction in proinflammatory cytokines and circulating immune complexes, along with increased IL-10 levels and phagocytic activity, suggesting an immunomodulatory effect that reduces inflammation and restores immune balance.

In this study using mouse models, researchers found that elevated IL-17a in aged olfactory epithelium impairs olfactory function, while IL-17a inhibition promotes regeneration and mitigates age-related decline.

In this animal study, AGO (agomelatine) effectively alleviated testosterone-induced benign prostatic hyperplasia in rats by reducing oxidative stress and inflammation, indicating its potential as a therapeutic option for managing BPH through specific signaling pathways.

This study found that combining metformin and clomifene citrate improved pregnancy outcomes and reduced miscarriage rates in women with PCOS and infertility undergoing intrauterine insemination.

Brodalumab effectively treated a man's severe hand and foot psoriasis.

This study reported that dupilumab, an FDA-approved biologic, is a safe and effective first-line systemic treatment for children with moderate-to-severe atopic dermatitis, showing sustained skin improvement and itch reduction, with injection site reactions and conjunctivitis as potential side effects.

In this case report, a patient with severe atopic dermatitis experienced significant improvement with dupilumab after other treatments, including immunosuppressive agents, failed to control the disease.

In a systematic review and meta-analysis, the researchers found that intralesional triamcinolone acetonide was more effective than cryotherapy for achieving significant hair regrowth in patients with patchy alopecia areata, although both treatments had distinct safety profiles.

This narrative review reports that IL-17 and IL-23 inhibitors, while effective for psoriasis and other inflammatory diseases, can cause a variety of skin reactions that resemble primary dermatoses, highlighting the need for careful diagnosis and varied management strategies.

This study found that while all hair removal techniques increased axillary erythema and skin dryness, shaving caused less erythema but more dryness than plucking or waxing, without affecting post-inflammatory hyperpigmentation or other skin properties.

This study observed that hair cortisol levels increased during pregnancy and positively correlated with certain systemic cytokines postpartum, suggesting potential associations with perinatal outcomes.

This study found that intramuscular anti-IFN-γ significantly stabilized and promoted hair regrowth in alopecia areata patients with patchy, progressive hair loss, whereas those with total baldness showed more limited improvement.

This study found that alopecia areata patients who responded poorly to topical immunotherapy had impaired peripheral blood mononuclear cell responses to T-cell stimulants.

IL-27 may help prevent hair loss by creating immune-suppressing cells.

This study found that plasmacytoid dendritic cells may initiate alopecia areata in mice by overexpressing interferon-alpha.

IL-17 and IL-23 inhibitors may cause hair loss.

In a murine model of alopecia areata, this study observed that the IL-2 fusion protein HCW9302 helped prevent disease development by expanding regulatory T cells and reducing disease-causing effector T cell infiltrates, suggesting potential for using IL-2 fusion proteins in alopecia areata treatment.

This study suggests a potential role for S100A7 and IL-17 in the pathogenesis of lichen planopilaris.

This study observed that male patients with alopecia areata had elevated serum levels of HSP70 and IL-15, with levels increasing alongside disease severity, suggesting these markers are strongly associated with the disease's pathogenesis.

This study found that patients with alopecia areata had increased levels of serum immunoglobulin E and interleukin-13 compared to healthy controls, with additional variation in levels observed across age and weight.

In this study, PA-011, a traditional Chinese medicine extract, was shown to improve hair growth in alopecia areata model mice by reducing skin inflammation and altering skin microbiota, indicating its potential therapeutic role for this condition.