research Differential Effects of Wnt5a on the Proliferation, Differentiation, and Inflammatory Response of Keratinocytes
Wnt5a may contribute to psoriasis by reducing skin cell growth, blocking skin cell maturation, and increasing inflammation.
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research Challenging Regional Psoriasis and Ustekinumab Biotherapy: Impact of the Patterns of Disease
Ustekinumab might work for severe psoriasis, but more research is needed to be sure.
research Cytokine-Targeted Treatment in Alopecia Areata - New Possibilities?
New cytokine-targeted therapies show promise for treating alopecia areata.
research Endocannabinoid-Like Molecule Oleoylethanolamide Promotes Sebaceous Lipid Synthesis
Oleoylethanolamide (OEA) safely boosts fat production in skin cells and may help treat dry skin and reduce inflammation.
research Use of Ultra-Fast One-Step CK5 IHC for Identifying BCC and SCC During Mohs Surgery
A new one-step test can quickly identify skin cancer during surgery.
research Structural Changes in Human Skin After Topical Application of Glucocorticoids Assessed by In Vivo Imaging Technologies
Topical glucocorticoids thin the skin and change collagen structure.
research Peroxisome Proliferator Activated Receptor-Gamma Tissue Expression and Gene Polymorphism in Alopecia Areata in an Egyptian Sample
PPAR-γ may be a key target for treating alopecia areata and other skin conditions.
research T Cell and Bacterial Microbiota Interaction at Intestinal and Skin Epithelial Interfaces
T cells and bacteria in the gut and skin help maintain health and protect against disease.
research Claudin-1 and Claudin-3 Maintain Proper Hair Follicle Structure and Regulate Telogen Effluvium
Claudin-1 and Claudin-3 are crucial for keeping hair follicle structure and preventing a type of hair loss called telogen effluvium.
research Aqueous Extract of Mentha Suaveolens Induces Nrf-2 Activation and Expression of Antioxidant and Detoxifying Enzymes in Human Keratinocyte HaCaT
Mint water extract boosts protective enzymes in skin cells.
research Nicotinic Acid Suppresses Sebaceous Lipid Synthesis of Human Sebocytes via Activating Hydroxycarboxylic Acid Receptor 2 (HCA2)
Nicotinic acid reduces excessive oil production in skin cells by activating a specific receptor, which could help treat acne.
research Effect of Minoxidil on Hair Growth in Minipigs
Minoxidil didn't significantly increase hair growth in minipigs.
research Orchestrated Cytotoxic and Skin Migratory Ability Lacking Self-Tolerance: Circulating γδT-Cells May Promote Alopecia Areata
The role of γδT-cells in causing alopecia areata remains unclear.
research Measurement of Level of Vitamin D and Antioxidants in Discoid Lupus Erythematosus Patients
Patients with Discoid Lupus Erythematosus have lower vitamin D and antioxidant levels and higher oxidative stress.
research A Novel Small Compound HPH-15 Antagonizes TGF-β/Smad Signaling and Ameliorates Experimental Skin Fibrosis
HPH-15, a new compound, effectively reduces skin fibrosis in experiments without causing harm.
research Deep Phenotyping of Patients with Xeroderma Pigmentosum and Trichothiodystrophy
Deep phenotyping helps distinguish between xeroderma pigmentosum and trichothiodystrophy, aiding in diagnosis and treatment.
research Clinical Snippets: R-Spondin2 Amplifies Wnt Signaling for Hair Growth, Gene Expression Differences in Balding Scalp, IKB Regulates hBD2 in Psoriasis, ß-Defensin Gene Cluster and Hidradenitis Suppurativa, Autoantigen Epitopes in Alopecia Areata
New treatments for hair growth and psoriasis may be possible, and gene differences could affect baldness and the severity of skin conditions.
research Highlights
Acne is not a key diagnostic feature for PCOS, postadolescent men with acne may have insulin resistance, melanoma patients often have few moles, tumor size in CSCC indicates higher risk of serious outcomes, and hidradenitis suppurativa is linked to higher risk of heart problems and death.
research Treatment of Nodulocystic Acne with Once Weekly Finasteride: A Pilot Study
research The Role of Local and Systemic Leptin in Androgenetic Alopecia
Higher leptin levels link to hair loss.
research Roles of Tumor Suppressors in Regulating Tumor-Associated Inflammation
Tumor suppressors help control inflammation in cancer and restoring their function could lead to new treatments.
research Regulatory T Cells in Inflammatory Skin Disease: From Mice to Humans
Special immune cells called Regulatory T cells help control skin inflammation and repair in various skin diseases.
research Tissue Resident and Follicular Treg Cell Differentiation Is Regulated by CRAC Channels
CRAC channels are crucial for the development and function of specialized immune cells, preventing severe inflammation and autoimmune diseases.
research CD4+CD25+FoxP3+ Regulatory Tregs Inhibit Fibrocyte Recruitment and Fibrosis via Suppression of FGF-9 Production in the TGF-β1 Exposed Murine Lung
Special immune cells called Tregs can help prevent lung scarring by blocking a specific growth factor.
research The Influence of Interferon on Healthy and Diseased Skin
Type I interferons play a key role in the development of various skin diseases.
research Breakdown of Immune Tolerance in AIRE-Deficient Rats Induces a Severe Autoimmune Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy–Like Autoimmune Disease
AIRE-deficient rats developed severe autoimmune disease similar to APECED, useful for testing treatments.
research Safety of Treatment Options for Spondyloarthritis: A Narrative Review
Most treatments for spondyloarthritis are safe, but monitoring and careful selection based on patient risks are important.
research Cutaneous Manifestations in Biologically Treated Inflammatory Bowel Disease Patients: A Narrative Review
Biologic treatments for Crohn's disease and ulcerative colitis can cause skin problems, and doctors should adjust treatment if these occur.
research Flightless I Exacerbation of Inflammatory Responses Contributes to Increased Colonic Damage in a Mouse Model of Dextran Sulfate Sodium-Induced Ulcerative Colitis
High levels of the protein Flightless I worsen ulcerative colitis symptoms in mice.
research Overexpression of Hypoxia-Inducible Factor-1α in Hidradenitis Suppurativa: The Link Between Deviated Immunity and Metabolism
Increased HIF-1α is linked to the inflammation and severity of hidradenitis suppurativa, suggesting treatments that lower HIF-1α could help.