July 2026 in “JAAD reviews.” This literature review highlights a potential but uncertain link between GLP-1 receptor agonist therapy for type 2 diabetes and obesity and hair loss, with variations among different medications.
March 2021 in “World rabbit science” This study found that taurine dietary supplementation could reduce lipid metabolism, enhance antioxidant capacity, and improve hormone levels in Angora rabbits, with 0.2% taurine increasing wool production.
April 2018 in “Journal of Investigative Dermatology” In this study, topical tofacitinib significantly promoted hair regrowth in mice, outpacing both minoxidil and controls over 21 days, with findings suggesting increased VEGF levels and decreased inflammation as possible mechanisms.
August 2023 in “Journal of Investigative Dermatology” In this study, researchers found that Ganoderma Lucidum extract and Ganoderic acid A significantly improved hair follicle growth and delayed hair loss progression, based on in vitro, ex vivo, and 24-week human clinical trials, suggesting potential as a therapeutic for androgenetic alopecia.
In this study, six-week-old male mice showed significantly increased hair regrowth rates and higher expression of hair growth-related factors when treated for 22 days with Lactobacillus strains and fermented Korean berry, suggesting these could be potential promoters of hair growth via gut microbiome regulation.
This study found that treating sheep hair follicles with IGFⅠ and EGF stimulated growth, with EGF also accelerating cell differentiation and altering the growth cycle.
1 citations
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January 2010 in “Shenyang Nongye Daxue xuebao” This study found that combining IGF-1 and EGF in specific concentrations significantly stimulated hair follicle growth in vitro for primary follicles from Liaoning cashmere goats.
39 citations
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January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” This article discusses the role of growth hormone, insulin, and IGF-1 in acne development and highlights how diet and syndromic evidence support their involvement, but presents no new clinical findings.
2 citations
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January 2014 in “Hair therapy & transplantation” This review explores the molecular controls of hair follicle cycling and highlights the challenge of developing effective treatments for common hair disorders without providing new clinical results.
138 citations
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July 2015 in “Clinical, Cosmetic and Investigational Dermatology” This review discusses how Western diet may contribute to acne vulgaris through insulin signaling and metabolomic changes, promoting a dietary approach for management, but reports no new experimental results.
3 citations
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June 2017 in “Journal of Biomaterials Applications” This study demonstrated that keratin extract can stimulate hair growth by inducing the anagen phase in telogenic mice.
1 citations
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January 2015 in “Hair therapy & transplantation” This investigation found that certain supplements, particularly whey protein isolate, growth hormones, and anabolic steroids, can negatively impact hair loss by affecting biochemical pathways.
113 citations
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November 2017 in “Scientific Reports” This study found that treatment with mesenchymal stem cell extracellular vesicles enhanced hair growth in mice and stimulated dermal papilla cell activity and growth factor production in vitro.
39 citations
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March 2008 in “Growth hormone & IGF research” Raspberry ketone may help grow hair and improve skin elasticity.
22 citations
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February 2017 in “Clinical and Experimental Dermatology” This study suggests that icariin promotes hair follicle growth in mice by enhancing IGF-1 expression in dermal papilla cells.
2 citations
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January 2021 in “Journal of Cosmetics, Dermatological Sciences and Applications” In this study, phenol-enriched olive mill wastewater extract positively influenced hair growth in vitro by promoting human dermal papilla cell proliferation, increasing insulin-like growth factor-1 secretion, and reducing reactive oxygen species, suggesting it may be beneficial for hair care.
146 citations
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January 2004 in “Hormones” This review explores the complex endocrine functions of human skin and its role as a peripheral endocrine organ, but reports no new clinical results.
75 citations
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October 2002 in “Journal of Dermatological Science” This study found that Sophora flavescens extract may promote hair growth in mice by inducing earlier hair cycle changes and regulating growth factors in dermal papilla cells.
28 citations
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September 2019 in “International Journal of Nanomedicine” This study found that minoxidil nanoparticles increased drug delivery to hair follicles and improved hair growth more effectively in mice than conventional minoxidil formulations.
24 citations
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May 2010 in “Hautarzt” This review explores various hormone influences on hair growth and loss beyond androgens, noting that clinical hormone therapies for aging may impact hair due to associated hormone level reductions, but reports no new empirical results.
21 citations
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February 2021 in “Frontiers in Endocrinology” This review explores the potential impact of hormonal changes during aging on benign prostate hyperplasia-related urinary symptoms and metabolic syndrome, highlighting the hypothesis of a male PCOS-equivalent but reports no new clinical results.
19 citations
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November 2001 in “Journal of Investigative Dermatology Symposium Proceedings” This study observed that human hair follicles with a completely destroyed bulb can regenerate after being grafted onto immunodeficient mice, entering a shortened dystrophic telogen followed by anagen phase.
7 citations
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March 2021 in “Evidence-based Complementary and Alternative Medicine” This study found that Nelumbinis Semen extract may promote hair growth and reduce hair loss by increasing VEGF and IGF-1 expression and decreasing TGF-β1 in human dermal papilla cells and mice.
5 citations
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May 2017 in “Current Opinion in Pediatrics” This review found that hormonal therapies, including FDA-approved combined oral contraceptive pills and spironolactone, are effective and well-tolerated treatments for acne vulgaris in adolescents with or without endocrine disorders, providing alternative options to antibiotics.
5 citations
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January 2004 in “Japanese journal of geriatrics” In this study, androgens were found to stimulate keratinocyte growth in co-culture with beard dermal papilla cells but inhibit it in co-culture with balding frontal scalp DPCs, mediated by TGF-beta1.
4 citations
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April 2012 in “Asian-australasian Journal of Animal Sciences” This study found that applying deer antler extract to rat skin wounds enhanced hair growth and increased IGF-I expression, suggesting potential use in hair growth products.
3 citations
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November 2005 in “Dermatologic Surgery” This study found that aminoguanidine induced increased VEGF mRNA expression in stored hair follicle micrografts, suggesting potential for developing growth-promoting storage solutions in hair restoration surgery.
2 citations
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July 2019 in “PeerJ” This study found that the vitamin D receptor plays a crucial role in hair follicle development in cashmere goats by regulating signaling pathways in dermal papilla cells.
2 citations
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January 2019 in “Annals of Dermatology” This preliminary study found that Melandrium firmum extract may promote hair growth and inhibit 5α-reductase, suggesting potential as a candidate for treating androgenetic alopecia.
2 citations
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January 2004 in “Enshou saisei” This study suggests that beard dermal papilla cells may produce androgen-dependent growth factors that stimulate keratinocyte proliferation, while frontal scalp cells can have an inhibitory effect mediated by TGF-β1.