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This study found that IGF-1 injections increased hair follicle number and growth phase duration in wild-type mice, suggesting potential for baldness treatment.

This study suggests that using growth factors and ADSC-conditioned medium can enhance keratinocyte viability and migration in epidermal transplantation, potentially improving chronic wound healing rates with a patient-dependent effect.

In this study, an innovative microneedle platform loaded with IGF-1 and modified collagen was reported to significantly promote hair regeneration, enhance neovascularization, and reduce inflammation in a mouse model of androgenetic alopecia, outperforming the commonly used minoxidil treatment.

This article reviews the role of IGF-1 in acne pathogenesis and discusses how diet and smoking may influence insulin/IGF-1 signaling, but reports no new clinical results.

The researchers reported that several m6A-related genes, particularly IGF2BP3, were differentially expressed in keloid tissue compared to normal skin, indicating potential targets for understanding keloid pathogenesis and treatment.

This study reported that IGF2BP2 rs1470579 and IGFBP3 rs2854744 may increase the risk of polycystic ovary syndrome in a Southeastern Iranian population.

This study reviewed competing endogenous RNA networks related to skin aging and wound healing, finding mechanisms like UVB-induced senescence and photoaging, as well as potential therapeutic targets for improving skin health and recovery.

This study found that a single 8Gy dose of superficial 50kV X-ray radiation minimizes keloid recurrence after excision, and identified genomic pathways and potential molecular targets for improved keloid therapy.

This study found that the IGF2 gene Apa1 A820G polymorphism is associated with an increased risk of developing PCOS in the studied population.

In this study, researchers explored hair follicle development in Qianhua Mutton Merino sheep, identifying key genes like KRT27 and IGF-2 that impact this process, with findings suggesting significant molecular changes as sheep mature from newborn to one year old.

This study identified m6A-related genes, particularly IGF2BP3, as significantly up-regulated in keloid patients, potentially implicating them in the condition's molecular mechanisms and suggesting targets for therapy.

This article discusses the role of growth hormone, insulin, and IGF-1 in acne development and highlights how diet and syndromic evidence support their involvement, but presents no new clinical findings.

This study found that dermal papilla cells from balding scalp follicles secrete significantly less insulin-like growth factor-1 and its binding proteins, suggesting a mechanism contributing to male pattern baldness.

The document concludes that there are still unknowns about the effectiveness, risks, and detection of performance-enhancing drugs, and doping remains a challenge.

This review discusses the diagnostic challenges of androgen and estrogen-secreting adrenal tumors and highlights that the presence of metastases is the most reliable indicator of malignancy; it reports no new clinical findings.

This review explores the molecular controls of hair follicle cycling and highlights the challenge of developing effective treatments for common hair disorders without providing new clinical results.

In a murine model of androgenetic alopecia, this study found that the newly designed IGF-1 biomimetic peptide Ac-GFFY-IGF led to faster and superior hair regrowth compared to minoxidil, suggesting potential for improved human therapies.

This study observed that IGF-1R expression significantly decreased in basal keratinocytes of sacrococcygeal pilonidal sinus tissues, suggesting a potential role in its etiology, although further data are needed to evaluate its treatment implications.

This study found that supplementing Angora goats with whole field bean seeds postpartum did not prevent weight and body condition losses but was associated with improved mohair growth and kid weight gain, likely due to better nutrient partitioning towards lactation and hair growth.

This review discusses hormones that affect acne and highlights a statistically significant link between a low-glycemic-load diet and reduced acne activity, but reports no new experimental findings.

This review discusses the complex relationship between anabolic substances and colorectal cancer risk, reporting ambiguous findings on their carcinogenic properties, potential synergy with risk factors, and protective roles.

This study found that SARS-CoV-2 hijacks the host factor IGF2BP1 to stabilize its RNA and enhance translation, and identified Cepharanthine and Trifluoperazine as potential treatments against the virus.

This study found that the protein Foxn1 is crucial for the development and fat-storing capacity of dermal white adipose tissue in mice, influencing both lipid metabolism and adipogenesis in the skin through Bmp2 and Igf2 signaling pathways.

This study found that in mice, epidermal Wnt/β-catenin signaling influences adipocyte differentiation and hair growth, suggesting its critical role in synchronizing adipogenesis with the hair growth cycle.

This study analyzed the transcriptome of the Tianzhu white yak, identifying differential transcripts that shed light on the molecular mechanisms influencing hair length growth variation in this species.

This commentary highlights the potential of using transgenic and genome-edited mouse models to validate findings from livestock genomic and multi-omic analyses, aiding in the understanding of economically significant animal traits.

This review highlights that genetically engineered mouse models are valuable for studying melanoma development and progression by mimicking human skin biology, revealing key signaling pathways and molecular mechanisms that contribute to melanoma heterogeneity and offering insights into potential therapeutic targets.

mIGF-1 in skin cells speeds up wound healing and hair growth in mice without harmful effects.

In this study, deleting the Igf1 receptor in specific skin cells of mice affected hair follicle cycling but not overall skin health, suggesting Igf1r's role in hair cycle regulation through Bmp-4 activation.

This study found that GLI2 plays a key role in activating follistatin, an activin/BMP antagonist, in response to hedgehog signaling in human epidermal cells, with implications for hair follicle development and basal cell carcinoma.