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GlossaryInsulin-like Growth Factor 1 (IGF1)

hormone promoting cell growth and development, similar to insulin

Insulin-like Growth Factor 1 (IGF-1) is a hormone similar in structure to insulin that plays a crucial role in childhood growth and continues to have anabolic effects in adults. It is primarily produced in the liver and is stimulated by growth hormone (GH). IGF-1 is involved in cell growth, development, and repair, and has been studied for its potential effects on hair growth and the treatment of conditions like alopecia.

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research IGF1 and BM-MSC Incorporating Collagen-Chitosan Scaffolds Promote Wound Healing and Hair Follicle Regeneration

3 citations, January 2020 in “PubMed”

Adding insulin-like growth factor 1 and bone marrow-derived stem cells to a collagen-chitosan scaffold helps wounds heal faster and regrows hair follicles.

research Vitamin A Regulates Dermal Papilla Cell Proliferation and Apoptosis Under Heat Stress via IGF1 and Wnt10b Signaling

2 citations, August 2023 in “Ecotoxicology and environmental safety”

Vitamin A helps rabbit skin cells grow and survive heat stress.

research Overexpression of miR-122 Promotes Apoptosis of Dermal Papilla Cells by Directly Targeting IGF1R in Androgenetic Alopecia

2 citations, November 2021 in “Cell Biology International”

miR-122 causes hair loss by killing hair cells.

research EGFR Marks a Subpopulation of Dermal Mesenchymal Cells Highly Expressing IGF1 Which Enhances Hair Follicle Regeneration

1 citations, May 2023 in “PubMed”

A certain type of skin cell, marked by EGFR, produces a lot of IGF1 and helps hair follicles grow back faster.

research Hair Follicle Development of Rex Rabbits Is Regulated Seasonally by Wnt10b/β-Catenin, TGFβ-BMP, IGF1, and EGF Signaling Pathways

1 citations, December 2023 in “Animals”

Winter provides the best fur quality for Rex rabbits due to seasonal changes in specific signaling pathways.

research Regulation of Human Dermal Papilla Cell Production of Insulin-Like Growth Factor Binding Protein-3 by Retinoic Acid, Glucocorticoids, and Insulin-Like Growth Factor-1

37 citations, June 1996 in “Journal of cellular physiology”

Retinoic acid, glucocorticoids, and IGF1 increase IGFBP-3 production in human dermal papilla cells, affecting hair growth.

research Role of Insulin Resistance and Diet in Acne

39 citations, January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”

Eating high glycemic foods and drinking milk may worsen acne by increasing insulin and IGF-1 levels.

research M2 Macrophages Promote Wound-Induced Hair Neogenesis

27 citations, May 2018 in “Journal of Dermatological Science”

M2 macrophages, a type of immune cell, help in new hair growth on scars by producing growth factors.

research Expression of Steroidogenic Enzymes in Human Sebaceous Glands

25 citations, June 2014 in “Journal of Endocrinology/Journal of endocrinology”

Human sebaceous glands contain enzymes that affect androgen production and may influence sebum production and acne.

research Endocrinology of the Aging Prostate: Current Concepts

21 citations, February 2021 in “Frontiers in Endocrinology”

Hormones affect prostate health and disease, with certain hormone imbalances linked to prostate cancer and benign prostatic hyperplasia.

research Inhibition of Prolactin Promotes Secondary Skin Follicle Activation in Cashmere Goats

7 citations, March 2021 in “Journal of animal science/Journal of animal science ... and ASAS reference compendium”

Blocking prolactin increases the activity of secondary hair follicles in cashmere goats.

research Morphogenetic Mechanisms in the Cyclic Regeneration of Hair Follicles and Deer Antlers from Stem Cells

7 citations, January 2013 in “BioMed research international”

Hair follicles and deer antlers regenerate similarly through stem cells and are influenced by hormones and growth factors.

Antioxidant Efficacy and Effects on Expression of Growth Factors in Human Hair Follicle Dermal Papilla Cells of Rosa Multiflora Root Extracts

research Antioxidant Efficacy and Effects on Expression of Growth Factors in Human Hair Follicle Dermal Papilla Cells of Rosa Multiflora Root Extracts

6 citations, June 2017 in “Asian journal of beauty & cosmetology”

Rosa multiflora root extracts may help promote hair growth and have anti-aging benefits.

research Two-Cell Assemblage Assay: A Simple In Vitro Method for Screening Hair Growth-Promoting Compounds

5 citations, November 2020 in “Frontiers in Cell and Developmental Biology”

The "Two-Cell Assemblage" assay is a new, simple method to identify substances that may promote hair growth.

research Effects of Baicalin on Alopecia and the Associated Mechanism

2 citations, November 2022 in “BioMed Research International”

Baicalin may help treat hair loss by promoting hair follicle growth and activating specific cellular pathways.

research Change in Hair Growth-Related Gene Expression Profile in Human Isolated Hair Follicles Induced by 5-Alpha Reductase Inhibitors – Dutasteride and Finasteride – in the Presence of Testosterone

1 citations, June 2021 in “Singapore Medical Journal”

Dutasteride and finasteride can help increase hair growth gene expression but need further improvement.

research Analysis of Long Non-Coding and Messenger RNA Expression Profiles in the Skin Tissue of Super Merino and Small-Tailed Han Sheep

August 2024 in “Current Issues in Molecular Biology”

Key genes and RNAs related to hair growth in sheep were identified, aiding future breeding improvements.

research Identification of N6-Methyladenosine-Related Factors and the Prediction of the Regulatory Mechanism of Hair Follicle Development in Rex and Hycole Rabbits

November 2023 in “Biology”

N6-methyladenosine affects hair follicle development differently in Rex and Hycole rabbits.

The Formulation and In-Vitro Evaluation of WS Biotin, a Novel Encapsulated Form of D-Biotin with Improved Water Solubility for Hair and Skin Treatment Applications

research The Formulation and In-Vitro Evaluation of WS Biotin, a Novel Encapsulated Form of D-Biotin with Improved Water Solubility for Hair and Skin Treatment Applications

October 2023 in “International Journal of Cosmetic Science”

WS Biotin, a new form of D-Biotin, improves water solubility and shows potential for hair and skin care without being toxic at low levels.

research Hair Growth Effect of DN106212 in C57BL/6 Mouse and Its Network Pharmacological Mechanism of Action

June 2023 in “Current Issues in Molecular Biology”

DN106212, an extract from a plant, is better at promoting hair growth than other tested substances by affecting hair growth factors and follicle development.

research M2 Macrophages Promote Wound-Induced Hair Neogenesis Through the Production of Growth Factors

April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

M2 macrophages help hair regrowth in wounds by making growth factors.

research Hair Sciences: The Hair Cycle Discussed with Dr. Gilliam Westgate

May 2009 in “Hair transplant forum international”

Androgens affect hair growth and shedding, with genetic and non-genetic factors influencing baldness.

research Ganoderma Lucidum Extract Attenuates Corticotropin-Releasing Factor-Induced Cellular Senescence in Human Hair Follicular Cells

April 2023 in “Journal of Investigative Dermatology”

Ganoderma lucidum extract can potentially reduce stress-induced hair loss by slowing down premature hair aging and removing harmful substances.

research Water Extract of Cacumen Platycladi Promotes Hair Growth Through the Akt/GSK3β/β-Catenin Signaling Pathway

February 2023 in “Frontiers in Pharmacology”

Water extract of Cacumen Platycladi helps hair growth by activating specific cell pathways.

research Endocrine Disorders in Woodhouse-Sakati Syndrome: A Systematic Review of the Literature

31 citations, January 2014 in “Journal of endocrinological investigation”

Woodhouse-Sakati syndrome often causes sexual development issues, hair loss, learning disabilities, deafness, muscle contractions, limb pain, and diabetes.

Androgen Receptor Activation Integrates Complex Transcriptional Effects in Osteoblasts, Involving the Growth Factors TGF-β and IGF-I, and Transcription Factor C/EBPδ

research Androgen Receptor Activation Integrates Complex Transcriptional Effects in Osteoblasts, Involving the Growth Factors TGF-β and IGF-I, and Transcription Factor C/EBPδ

11 citations, July 2015 in “Gene”

DHT affects bone growth by altering gene activity in osteoblasts, potentially complicating steroid use.

research Transplanted Hair Follicle Mesenchymal Stem Cells Alleviated Small Intestinal Ischemia–Reperfusion Injury via Intrinsic and Paracrine Mechanisms in a Rat Model

6 citations, October 2022 in “Frontiers in Cell and Developmental Biology”

Transplanted hair follicle stem cells can heal damaged rat intestines.