research Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1 in Thymic Epithelial Cells
A specific DNA region is crucial for Foxn1 gene expression in thymus cells but not in hair follicles.
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research Mechanistic Analysis of Human Skin Distribution and Follicular Targeting of Adapalene-Loaded Biodegradable Nanospheres With Insight Into Hydrogel Matrix Influence, In Vitro Skin Irritation, and In Vivo Tolerability
Researchers developed a nanomedicine for acne treatment that delivers medication with less irritation and is non-irritating for oily skin.
research Rapid Intravenous Administration of Corticotropin as a Test of Adrenocortical Insufficiency
The rapid corticotropin test is a quick and simple way to diagnose adrenal insufficiency.
research TSPO Activation Modulates the Effects of High Pressure in a Rat Ex Vivo Glaucoma Model
Activating TSPO helps protect the retina from damage caused by high eye pressure in glaucoma.
research Specific Inhibition of FGF5-Induced Cell Proliferation by RNA Aptamers
RNA aptamers can specifically block FGF5-related cell growth, potentially treating related diseases or hair disorders.
research Development of Optimized Self-Nanoemulsifying Lyophilized Tablets to Improve Finasteride Clinical Pharmacokinetic Behavior
Improved tablets lead to faster, better drug absorption for hair loss treatment.
research Feline Dermatology: Comprehensive Overview of Skin Conditions in Cats
The document explains various skin conditions in cats and how to diagnose and treat them.
research A Systematic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia
Various treatments, including FDA-approved drugs, natural products, and oral supplements, can help with hair loss, but a patient's medical history and potential allergies should be considered when choosing a treatment.
research Single-Cell Transcriptomics Reveals Lineage Trajectory of Human Scalp Hair Follicle and Informs Mechanisms of Hair Graying
The study found new details about human hair growth and suggests that preventing a specific biological pathway could potentially treat hair graying.
research Homo- and Heteropolymer Self-Assembly of Recombinant Trichocytic Keratins
Recombinant keratins can form useful structures for medical applications, overcoming natural keratin limitations.
research In Vitro Selective Inhibition of Human UDP-Glucuronosyltransferase (UGT) 1A4 by Finasteride and Prediction of In Vivo Drug–Drug Interactions
Finasteride affects UGT1A4 enzyme, but not enough to cause issues when combined with other drugs.
research Modulation of the 6-Position of Benzopyran Derivatives and Inhibitory Effects on the Insulin Releasing Process
Changing the 6-position on benzopyran molecules affects insulin release, with some compounds showing strong inhibitory effects.
research Rat Steroid 5α-Reductase Kinetic Characteristics: Extreme pH-Dependency of the Type II Isozyme in Prostate and Epididymis Homogenates
The activity of a specific rat enzyme in the prostate and epididymis is highly dependent on the acidity level.
research An In Vitro Model for the Study of Human Hair Growth
Researchers created a lab model to study human hair growth, showing it can grow and self-regulate outside the body.
research Hair Regenerative Effect of Silk Fibroin Hydrogel with Incorporation of FGF-2-Liposome and Its Potential Mechanism in Mice with Testosterone-Induced Alopecia Areata
The silk fibroin hydrogel with FGF-2-liposome can potentially treat hair loss in mice.
research Mouse Hair Cycle Expression Dynamics Modeled as Coupled Mesenchymal and Epithelial Oscillators
The study concluded that hair growth in mice is regulated by a stable interaction between skin cell types, and disrupting this can cause hair loss.
research Anti-Zika Activity of a Library of Synthetic Carbohydrate Receptors
Some synthetic carbohydrate receptors, especially compounds 3 and 15, show strong potential for treating Zika virus.
research Early Plant Growth and Biochemical Responses Induced by Azospirillum Brasilense Sp245 Lipopolysaccharides in Wheat (Triticum Aestivum L.) Seedlings Are Attenuated by Procyanidin B2
Lipopolysaccharides boost wheat seedling growth, but procyanidin B2 weakens this effect.
research Polyphenols Rich Hibiscus Rosa Sinensis Linn. Petals Modulate Diabetic Stress Signaling Pathways in Streptozotocin-Induced Experimental Diabetic Rats
Hibiscus petals improved blood sugar and stress responses in diabetic rats.
research Environmental Exposure to Platinum Group Elements Released by Automotive Catalytic Converters: The Risk for Children
Children are at risk of health issues from exposure to platinum group elements from car exhausts.
research Flutamide-Loaded Zein Nanocapsule Hydrogel: A Promising Dermal Delivery System for Pilosebaceous Unit Disorders
The flutamide-loaded hydrogel is a promising, skin-friendly treatment for acne and hair loss, potentially requiring less frequent application.
research Bisphenol-A Antagonizes the Rapidly Modulating Effect of Dihydrotestosterone on Spinogenesis and Long-Term Potentiation of Hippocampal Neurons
Bisphenol-A (BPA) increases connections between brain cells and boosts their activity, but it blocks the effects of a male hormone on brain cell plasticity.
research Hibiscus Rosa Sinensis Linn. Petals Modulate Glycogen Metabolism and Glucose Homeostasis Signaling Pathway in Streptozotocin-Induced Experimental Diabetes
Hibiscus petals helped control blood sugar and improve liver and pancreas health in diabetic rats.
research The Peptide AC 2 Isolated from Bacillus-Treated Trapa Japonica Fruit Extract Rescues DHT-Treated Human Dermal Papilla Cells and Mediates mTORC1 Signaling for Autophagy and Apoptosis Suppression
The AC 2 peptide from Trapa japonica fruit helps protect hair cells and may treat hair loss.
research Fundamental Studies on the Interaction Between Moisture and Textiles. Part X. Moisture Sorption Properties of Wool and Hair Fibers
Wool and hair fibers absorb moisture similarly due to their keratin structure, with the amount of non-crystalline areas affecting the moisture uptake.
research Determination of Cystine and Cysteine in Altered Human Hair Fibers
Cold waving solutions quickly reduce cystine to cysteine in hair.
research Effect of Finasteride Particle Size Reduction on Its Pharmacokinetic, Tissue Distribution, and Cellular Permeation
Smaller finasteride particles increase effectiveness in treating hair loss.
research Adult-Onset Hair Loss in Chesapeake Bay Retrievers: A Clinical and Histological Study
Chesapeake Bay retrievers' hair loss is likely a breed-specific, hereditary condition linked to abnormal steroid levels and distinct skin changes.
![Synthesis of Spiro[cyclohexane-1,2'-[2H]indene] Derivatives as Inhibitors of Steroid 5α-Reductase](/images/research/d91300a7-4d66-4d2c-90ac-293b0dbc5ff5/small/21048.jpg)
research Synthesis of Spiro[cyclohexane-1,2'-[2H]indene] Derivatives as Inhibitors of Steroid 5α-Reductase
Compound 15a was effective in inhibiting 5α-reductase.
research Hair Growth Promoting Effect of 4HGF Encapsulated with PGA Nanoparticles by β-Catenin Activation and Related Cell Cycle Molecules
PGA-4HGF may help treat hair loss by activating hair growth pathways and extending the hair growth phase.