Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review discusses the development and selectivity of 5 alpha-reductase inhibitors, particularly non-steroidal ones, and reports no new clinical trial results.

This study found that polymeric nanoparticles may effectively deliver finasteride topically to hair follicles, potentially improving alopecia treatment with fewer side effects than oral forms.

This study found that dutasteride-loaded nanostructured lipid carriers coated with a stearic acid-chitosan oligomer are stable, less cytotoxic, and suitable for topical delivery to promote hair growth.

This article reviews various strategies, primarily developed by the Turin University Pharmaceutical Technology group, for increasing entrapment efficiency of hydrophilic molecules in nanoparticulate systems and reports no clinical results.

This review discusses the role of pharmacological sciences in advancing regenerative medicine technologies but reports no new experimental findings; the authors advocate for increased pharmacologist involvement to drive innovations.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

This review compiles current information about Eclipta prostrata, traditional uses, and its promising pharmacological properties, like hepatoprotective and anti-inflammatory effects, but emphasizes that more research is needed to fully understand its mechanisms and ensure safety for clinical application.

This review suggests that brassinosteroids may have similar biological activities in both plants and other organisms, prompting further exploration of steroid regulation mechanisms across different life forms.

This review discusses the use of 5α-reductase inhibitors, particularly finasteride, for treating conditions like benign prostatic hyperplasia, male baldness, and hirsutism, and reports no new clinical results.

This study found that SRD5a-3 is a highly efficient enzyme for converting hormones into androgens, with dutasteride being a much more potent inhibitor of SRD5a-3 than SRD5a-2.

This study found that novel androgen antagonists incorporating a carborane moiety showed anti-androgenic activity comparable to flutamide in a laboratory setting.

This review discusses the pharmacological properties and analytical methods for determining fluconazole but reports no new experimental findings.

This study found that Piper nigrum leaf extract showed in vivo anti-androgenic activity and potent 5α-reductase inhibitory effects, with piperine and (−)-cubebin identified as active components.

This review explores the potential of selective 11β-HSD1 inhibitors to improve insulin sensitivity in type 2 diabetes, emphasizing the need for more clinical research and reports no new clinical results.

This review discusses baricitinib's applications for various inflammatory disorders and highlights its promising efficacy alongside potential adverse effects, advocating for further research before it becomes a standard treatment.

This study found that newly synthesized steroidal trienones demonstrated stronger 5α-reductase inhibitory activity compared to dienones in various biological models, suggesting potential for developing enhanced antiandrogenic drugs.

This review discusses the potential of JAK inhibitors as a promising treatment strategy for alopecia areata, highlighting their mechanism and recent FDA approval based on clinical trial efficacy.

This review discusses the data resources and computational models used in drug repositioning, highlighting their role in discovering unknown drug mechanisms and reports no new empirical results.

This review summarizes causes and treatments of androgenetic alopecia with a focus on herbs as potential alternatives, but reports no new results and suggests more research is needed to validate these options.

This review suggests that skin may largely protect itself from CYP-generated reactive metabolites due to higher conjugating enzyme activities, while highlighting limitations in modeling human skin metabolism experimentally.

This study reported that the aqueous ethanol extract of Lygodii Spora demonstrated in vitro testosterone 5alpha-reductase inhibition and in vivo anti-androgenic activity, potentially due to oleic, linoleic, and palmitic acids.

This study found that procyanidin B-2 may promote hair growth by reducing expression and inhibiting translocation of PKC isozymes in murine hair epithelial cells.

This review synthesizes knowledge on Prostaglandin E2's role in platelet biology and suggests that targeting PGE2 pathways could lead to personalized antiplatelet therapy without affecting hemostasis, but it presents no new results.

This study found that Puerariae Flos extract inhibited testosterone 5α-reductase and promoted hair growth in mouse models, suggesting its potential use for treating androgenic alopecia.

Cromakalim relaxes various blood vessels, while minoxidil sulphate is more selective; they likely act on different potassium channels.

This review compiles studies on the antidiabetic potential of plants from the Middle East, particularly from the Asteraceae and Lamiaceae families, but reports no clinical results.

In this study, procyanidin B-2 and C-1 were found to promote hair growth by selectively inhibiting protein kinase C, supporting their potential use for hair-growing activity.

This study suggests that silver nanoparticles synthesized using Grewia optiva leaf extract exhibit stronger antibacterial and antioxidant properties than the leaf extract alone.

This review reports on the traditional and ethnopharmacological uses of Ziziphus jujuba Mills, noting its increasing global popularity for treating various ailments, but highlights that its acceptance into the European Pharmacopoeia remains unresolved due to scientific and regulatory challenges.

This review discusses the traditional uses and pharmacological properties of Hedychium spicatum, noting that while some traditional uses are supported by scientific studies, further research on its applications is needed.