278 citations
,
March 2013 in “Gut” In this study, nearly 5% of anti-TNF-treated patients with IBD developed psoriasiform skin lesions, with smoking identified as a main risk factor, and ustekinumab proved highly effective in severe cases.
70 citations
,
February 2016 in “EMBO reports” This study identified a subtype of itch-sensing neurons in mice, which express Ret and somatostatin, and found that their ablation reduces scratching induced by certain pruritogens.
63 citations
,
March 1995 in “International Journal of Dermatology” Some drugs can cause hair loss, and stopping these drugs often leads to hair regrowth.
58 citations
,
September 2019 in “EMBO Molecular Medicine” This study found that the CDK4/6 inhibitor palbociclib may protect human hair follicles from the damaging effects of taxane chemotherapy by inducing G1 arrest in stem/progenitor cells.
53 citations
,
September 2004 in “American journal of medical genetics. Part C, Seminars in medical genetics” This review discusses the range of diseases caused by mutations in keratin intermediate filament genes and presents no new clinical findings; the authors note the diverse phenotypes within this molecular category.
47 citations
,
November 2012 in “Pharmaceutical research” This study found that surface modified nanoparticles showed increased skin permeation and improvement in allergic contact dermatitis, independent of the follicular pathway.
40 citations
,
January 2017 in “Intestinal Research” This study found that among Japanese IBD patients, the NUDT15 p.Arg139Cys variant was significantly associated with thiopurine-induced leukopenia and severe hair loss, suggesting its genotyping is important for predicting these adverse events.
34 citations
,
March 2015 in “Clinical and Experimental Dermatology” This study observed that patients with pemphigus have a higher incidence of hypothyroidism, inflammatory bowel disease, and diabetes compared to the general population.
29 citations
,
February 2016 in “Scandinavian journal of urology” This study suggests a possible link between late puberty onset and decreased prostate cancer risk, while over-the-counter ibuprofen use was associated with increased risk.
28 citations
,
March 2018 in “Scientia Horticulturae” This study found that 3-indolebutyric acid (IBA) increased root-hair growth in trifoliate orange by elevating auxin levels, while 2-naphthoxyacetic acid (2-NOA) had the opposite effect, inhibiting root-hair growth.
26 citations
,
October 2017 in “Clinical Reviews in Allergy & Immunology” This review explores skin manifestations associated with autoimmune liver diseases and highlights known and probable links, such as vitiligo's strong association with autoimmune hepatitis.
21 citations
,
September 2021 in “New Phytologist” This study found that the transcription factor HB24 plays a critical role in root hair elongation in Arabidopsis thaliana by promoting the conversion of indole-3-butyric acid to indole-3-acetic acid through regulation of IBR1 expression.
18 citations
,
April 2013 in “Inflammatory Bowel Diseases” This review discusses the various potential causes of hair loss in patients with inflammatory bowel disease, including telogen effluvium from disease flares, but provides no prevalence data; the authors outline a practical assessment and management approach.
12 citations
,
March 2012 in “ATLA. Alternatives to laboratory animals” This study found that caffeine and flufenamic acid penetrated porcine skin more effectively through hair follicles, while the importance of the follicular pathway varied for other substances tested.
9 citations
,
January 2018 in “Acta Clinica Croatica” This review suggests that bendamustine, alone or in combination, shows effectiveness in treating indolent non-Hodgkin lymphoma and chronic lymphocytic leukemia, with recent studies highlighting its benefits especially in combination therapies, while balancing efficacy with a favorable toxicity profile.
5 citations
,
May 2016 in “Jahangirnagar University Journal of Biological Sciences” This study demonstrated that the most effective method for inducing multiple shoots and root development in Eclipta alba involved specific concentrations of plant hormones on MS medium, resulting in healthy, flowering plantlets.
3 citations
,
November 2016 in “Clinical Pediatrics” A girl with Crohn's disease developed hair loss from her medication, which improved with treatment but later returned.
3 citations
,
March 2015 in “Journal of the European Academy of Dermatology and Venereology” Some people with primary cicatricial alopecia also have inflammatory bowel disease, suggesting a possible connection.
2 citations
,
August 2017 in “Experimental Dermatology” This study developed a new melanocyte cultivation medium without chemical mitogens, melanogenesis enhancers, or bovine products, demonstrating successful proliferation and melanotic differentiation of human melanocytes from hair follicles.
1 citations
,
September 2025 in “Physiologia” This study found that systemic ovalbumin–aluminum sensitization followed by cutaneous challenge in mice induced thermal hyperalgesia, increased spinal cord gliosis, and sprouting of nociceptive fibers, along with elevated mast cell and nerve profile densities in the skin compared to controls.
1 citations
,
February 2021 in “Gastroenterology” This report discusses a case of vesiculopustular eruption in a patient with ulcerative colitis, highlighting the effective use of ustekinumab for treatment and suggesting its consideration in similar cases of IBD-related skin lesions.
1 citations
,
January 2020 in “Journal of Crohn's and colitis” In this case series, researchers observed that patients with inflammatory bowel disease often experienced vitamin C deficiency, which was linked to symptoms of scurvy, highlighting the need for dietary counseling.
January 2021 in “Springer eBooks” This chapter reviews skin manifestations in common rheumatic diseases, particularly those with polyarthritis, and offers a differential diagnosis of erythema nodosum without presenting new research findings.
May 2025 in “International Journal of Trichology” In this case report, the researchers observed scalp alopecia due to metastasis of breast cancer in a woman in her sixties, highlighting that scalp metastases can result in patchy hair loss and, although often accompanied by poor prognosis, can sometimes show comparatively better outcomes.
January 2025 in “International Journal of Advanced Research” In this case report, a 30-year-old male with alopecia universalis was diagnosed with ulcerative colitis, and despite treatment, he experienced no hair regrowth, highlighting that skin issues like alopecia can accompany inflammatory bowel diseases such as ulcerative colitis.
July 2024 in “Journal of Investigative Dermatology” Treating gastrointestinal issues can reduce rosacea flares, and treating rosacea can lower gastrointestinal problems.
April 2024 in “Research Square” IBD patients treated with TNF antagonists may develop autoimmune alopecia areata, with severe cases less likely to improve.
December 2022 in “Journal of Experimental Biology and Agricultural Sciences” This study found that a specific combination of plant growth regulators effectively enhanced in vitro propagation and rooting of Eclipta alba, potentially enabling commercial-scale plant production.
May 2020 in “International journal of biology, pharmacy and allied sciences” This review discusses the correlation between vitiligo and various autoimmune, systemic, and dermatological diseases, highlighting the need to increase awareness of these comorbidities.
December 2019 in “International journal of engineering applied science and technology” This review discusses the traditional uses of Tridax procumbens for wound healing, antifungal, and antibacterial purposes, but reports no clinical findings.