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    Did you mean Hypoxia-Inducible Factor 1-alpha?
    Glossary Hypoxia-Inducible Factor 1-alpha

    protein that helps cells adapt to low oxygen levels

    Hypoxia-Inducible Factor 1-alpha (HIF-1α) is a protein that helps cells respond to low oxygen levels (hypoxia). It activates various genes that enable cells to adapt to hypoxic conditions, such as those involved in increasing blood supply and altering metabolism. This protein is crucial in processes like wound healing and can also play a role in diseases like cancer, where it can help tumors grow by improving their oxygen supply.

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    1. Overexpression of hypoxia-inducible factor-1α in hidradenitis suppurativa: the link between deviated immunity and metabolism Archives of dermatological research · 2023 · 5 citations
    2. Hypoxia inducible factor-1a promotes trichogenic gene expression in human dermal papilla cells Research Square (Research Square) · 2022 · 1 citations
    3. HIF-1α Stimulators Function Equally to Leading Hair Loss Agents in Enhancing Dermal Papilla Growth Skin Pharmacology and Physiology · 2020 · 6 citations
    4. KRT17 promotes endometrial cancer cell migration as well as angiogenesis by regulating HIF-1α/VEGF pathway European journal of gynaecological oncology · 2023
    5. Scarless wound healing: Transitioning from fetal research to regenerative healing Wiley Interdisciplinary Reviews-Developmental Biology · 2018 · 79 citations
    6. UP-03.25 Urology · 2006
    7. A combination of pyridine‐2, 4‐dicarboxylic acid diethyl ester and resveratrol stabilizes hypoxia‐inducible factor 1‐alpha and improves hair density in female volunteers International Journal of Cosmetic Science · 2020 · 8 citations
    8. Hypoxia inducible factor-1α promotes trichogenic gene expression in human dermal papilla cells Scientific Reports · 2023 · 2 citations
    9. Insights into male androgenetic alopecia using comparative transcriptome profiling: hypoxia-inducible factor-1 and Wnt/β-catenin signalling pathways British Journal of Dermatology · 2022 · 1 citations
    10. Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production Journal of Medicinal Food · 2018 · 6 citations
    11. Immunohistochemical Analysis of the Mechanistic Target of Rapamycin and Hypoxia Signalling Pathways in Basal Cell Carcinoma and Trichoepithelioma PloS one · 2014 · 15 citations
    12. Spermidine/spermine-<i>N</i><sup>1</sup>-acetyltransferase: a key metabolic regulator AJP Endocrinology and Metabolism · 2008 · 305 citations
    13. FLCN regulates transferrin receptor 1 transport and iron homeostasis 2021 · 1 citations
    14. Hypoxia in Cell Reprogramming and the Epigenetic Regulations Frontiers in Cell and Developmental Biology · 2021 · 36 citations
    15. Understanding human aging and the fundamental cell signaling link in age-related diseases: the middle-aging hypovascularity hypoxia hypothesis Frontiers in Aging · 2023 · 4 citations
    16. Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche Cell stem cell · 2011 · 695 citations
    17. Transforming growth factor-β in stem cells and tissue homeostasis Bone Research · 2018 · 245 citations
    18. Functional enhancement strategies for immunomodulation of mesenchymal stem cells and their therapeutic application Stem Cell Research & Therapy · 2020 · 53 citations
    19. Insulin-like Growth Factor 1 (IGF-1) in Hair Regeneration: Mechanistic Pathways and Therapeutic Potential Current Issues in Molecular Biology · 2025
    20. Hypoxia Treatment of Adipose Mesenchymal Stem Cells Promotes the Growth of Dermal Papilla Cells via HIF-1α and ERK1/2 Signaling Pathways International Journal of Molecular Sciences · 2023 · 1 citations
    21. Hypoxic Preconditioning Prevents Oxidative Stress-Induced Cell Death in Human Hair Follicle Stem Cells. PubMed · 2024
    22. Referee report. For: Advances in Understanding Hair Growth [version 1; referees: 3 approved] Faculty of 1000 Research Ltd · 2016
    23. Referee report. For: Advances in Understanding Hair Growth [version 1; referees: 3 approved] Faculty of 1000 Research Ltd · 2016
    24. Conditioned media-integrated microneedles for hair regeneration through perifollicular angiogenesis Journal of Controlled Release · 2022 · 12 citations
    25. From Primary MSC Culture of Adipose Tissue to Immortalized Cell Line Producing Cytokines for Potential Use in Regenerative Medicine Therapy or Immunotherapy International Journal of Molecular Sciences · 2021 · 13 citations
    26. Potential mechanisms of exercise in maintaining skin homeostasis disrupted by protein deficiency (Review) World Academy of Sciences Journal · 2024
    27. Use of Botulinum Toxin for Androgenic Alopecia: A Systematic Review Skin appendage disorders · 2021 · 1 citations
    28. Identification of differentially expressed genes affecting hair and cashmere growth in the Laiwu black goat by microarray Molecular Medicine Reports · 2016 · 4 citations
    29. Primary Involvement of NADPH Oxidase 4 in Hypoxia-Induced Generation of Reactive Oxygen Species in Adipose-Derived Stem Cells Stem Cells and Development · 2011 · 67 citations
    30. The Role of Stem Cells in Cutaneous Wound Healing: What Do We Really Know? Plastic and Reconstructive Surgery · 2011 · 43 citations