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GlossaryHypoxia-Inducible Factor 1-alpha

protein that helps cells adapt to low oxygen levels

Hypoxia-Inducible Factor 1-alpha (HIF-1α) is a protein that helps cells respond to low oxygen levels (hypoxia). It activates various genes that enable cells to adapt to hypoxic conditions, such as those involved in increasing blood supply and altering metabolism. This protein is crucial in processes like wound healing and can also play a role in diseases like cancer, where it can help tumors grow by improving their oxygen supply.

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research Immunohistochemical Analysis of the Mechanistic Target of Rapamycin and Hypoxia Signalling Pathways in Basal Cell Carcinoma and Trichoepithelioma

15 citations , September 2014 in “PloS one”

The study found that analyzing certain cell signaling pathways is not a reliable method to tell apart two types of skin tumors.

research Overexpression of hypoxia-inducible factor-1α in hidradenitis suppurativa: the link between deviated immunity and metabolism

5 citations , March 2023 in “Archives of dermatological research”

Increased HIF-1α is linked to the inflammation and severity of hidradenitis suppurativa, suggesting treatments that lower HIF-1α could help.

research Hypoxia inducible factor-1α promotes trichogenic gene expression in human dermal papilla cells

2 citations , January 2023 in “Scientific Reports”

HIF-1α is important for hair growth and could be a treatment target for hair loss.

research Insights into male androgenetic alopecia using comparative transcriptome profiling: hypoxia-inducible factor-1 and Wnt/β-catenin signalling pathways

1 citations , July 2022 in “British Journal of Dermatology”

research KRT17 promotes endometrial cancer cell migration as well as angiogenesis by regulating HIF-1α/VEGF pathway

January 2023 in “European journal of gynaecological oncology”

KRT17 may be a new target for endometrial cancer treatment because it helps cancer cells move and form new blood vessels.

research Scarless wound healing: Transitioning from fetal research to regenerative healing

79 citations , January 2018 in “Wiley Interdisciplinary Reviews-Developmental Biology”

Understanding how baby skin heals without scars could help develop treatments for adults to heal wounds without leaving scars.

research Oxygen, Metabolism, and Regeneration: Lessons from Mice

35 citations , November 2017 in “Trends in Molecular Medicine”

Mice with enhanced regeneration abilities may help develop new regenerative medicine therapies.

research Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

695 citations , October 2011 in “Cell stem cell”

Low oxygen areas help maintain and protect blood stem cells by using a simple sugar breakdown process for energy and managing their activity levels.

research An Exploratory In Vivo Study on the Effect of Annurca Apple Extract on Hair Growth in Mice

1 citations , December 2022 in “Current Issues in Molecular Biology”

Annurca apple extract improved hair growth in mice and could potentially prevent hair loss.

Mechanical Stretch Upregulates SDF-1α in Skin Tissue and Induces Migration of Circulating Bone Marrow-Derived Stem Cells into the Expanded Skin

research Mechanical Stretch Upregulates SDF-1α in Skin Tissue and Induces Migration of Circulating Bone Marrow-Derived Stem Cells into the Expanded Skin

43 citations , December 2013 in “Stem Cells”

Stretching skin increases a certain protein that attracts stem cells, helping skin regeneration.

research Minoxidil Induction of VEGF Is Mediated by Inhibition of HIF-Prolyl Hydroxylase

22 citations , December 2017 in “International Journal of Molecular Sciences”

Minoxidil boosts hair growth by increasing blood flow and nutrients to hair follicles.

research Finasteride Reduces Microvessel Density and Expression of Vascular Endothelial Growth Factor in Renal Tissue of Diabetic Rats

7 citations , June 2015 in “The American Journal of the Medical Sciences”

Finasteride helps reduce blood vessel growth in diabetic rat kidneys.

research Possible Therapeutic Effects of Ozone Mixture on Hypoxia in Tumor Development

25 citations , February 2017 in “Anticancer Research/Anticancer research”

Ozone therapy might improve cancer treatment and reduce its side effects.

research Human hair follicles are an extrarenal source and a nonhematopoietic target of erythropoietin

71 citations , May 2007 in “The FASEB journal”

Human hair follicles produce and respond to erythropoietin, helping protect against stress.

research Regulatory T Cells: the Many Faces of Foxp3

125 citations , September 2019 in “Journal of Clinical Immunology”

Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.

research Extraskeletal actions of vitamin D

119 citations , July 2016 in “Annals of the New York Academy of Sciences”

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

research The role of lysophosphatidic acid in the physiology and pathology of the skin

24 citations , March 2019 in “Life sciences”

Lysophosphatidic acid is important for skin health and disease, and could be a target for new skin disorder treatments.

research Evaluation of hydro-alcoholic extract of Eclipta alba for its anticancer potential: An in vitro study

50 citations , June 2011 in “Journal of Ethnopharmacology”

Eclipta alba extract shows potential as an anticancer agent by inhibiting cancer cell growth and promoting cell death.

research Role of Growth Factors-Rich Plasma, Gel and Membrane in Dermal Wound Healing and Injured Tissue Restoration and Regeneration

1 citations , November 2021 in “European journal of medical and health sciences”

Growth factors-rich plasma treatments can significantly speed up wound healing and tissue regeneration.

research Wound Healing Impairment in Type 2 Diabetes Model of Leptin-Deficient Mice—A Mechanistic Systematic Review

10 citations , August 2022 in “International Journal of Molecular Sciences”

Leptin-deficient mice, used as a model for Type 2 Diabetes, have delayed wound healing due to impaired contraction and other dysfunctional cellular responses.

research NF-κB in biology and targeted therapy: new insights and translational implications

1 citations , March 2024 in “Signal transduction and targeted therapy”

NF-κB signaling is crucial in many diseases and can be targeted for new treatments.

research Mammalian Fetal Organ Regeneration

32 citations , January 2005 in “Advances in Biochemical Engineering / Biotechnology”

Fetal wounds heal without scarring because of different biological factors, which could help improve adult wound healing.

research Molecular Mechanisms Responsible for Therapeutic Potential of Mesenchymal Stem Cell-Derived Secretome

271 citations , May 2019 in “Cells”

The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.

Quantitative proteomic analysis of dermal papilla from male androgenetic alopecia comparing before and after treatment with low‐level laser therapy

research Quantitative proteomic analysis of dermal papilla from male androgenetic alopecia comparing before and after treatment with low‐level laser therapy

12 citations , September 2019 in “Lasers in Surgery and Medicine”

Low-level laser therapy improves hair growth and dermal papilla cell function.

research Alleviation of Multidrug Resistance by Flavonoid and Non-Flavonoid Compounds in Breast, Lung, Colorectal and Prostate Cancer

45 citations , January 2020 in “International Journal of Molecular Sciences”

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

Bioactive Molecules for Skin Repair and Regeneration: Progress and Perspectives

research Reversing Gray Hair: Inspiring the Development of New Therapies Through Research on Hair Pigmentation and Repigmentation Progress

2 citations , January 2023 in “International journal of biological sciences”

Gray hair can potentially be reversed, leading to new treatments.