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    Did you mean Hypoxia-Inducible Factor 1-alpha?
    Glossary Hypoxia-Inducible Factor 1-alpha

    protein that helps cells adapt to low oxygen levels

    Hypoxia-Inducible Factor 1-alpha (HIF-1α) is a protein that helps cells respond to low oxygen levels (hypoxia). It activates various genes that enable cells to adapt to hypoxic conditions, such as those involved in increasing blood supply and altering metabolism. This protein is crucial in processes like wound healing and can also play a role in diseases like cancer, where it can help tumors grow by improving their oxygen supply.

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    1. A combination of pyridine‐2, 4‐dicarboxylic acid diethyl ester and resveratrol stabilizes hypoxia‐inducible factor 1‐alpha and improves hair density in female volunteers International Journal of Cosmetic Science · 2020 · 8 citations
    2. Overexpression of hypoxia-inducible factor-1α in hidradenitis suppurativa: the link between deviated immunity and metabolism Archives of dermatological research · 2023 · 5 citations
    3. Hypoxia inducible factor-1α promotes trichogenic gene expression in human dermal papilla cells Scientific Reports · 2023 · 2 citations
    4. Insights into male androgenetic alopecia using comparative transcriptome profiling: hypoxia-inducible factor-1 and Wnt/β-catenin signalling pathways British Journal of Dermatology · 2022 · 1 citations
    5. Hypoxia inducible factor-1a promotes trichogenic gene expression in human dermal papilla cells Research Square (Research Square) · 2022 · 1 citations
    6. Iron Chelators in the Management of Autoimmune-Induced Alopecia: A Focus on Hypoxia-Inducible Factor 1 Modulation and Hair Restoration Journal of Clinical Medicine · 2025
    7. The potential role of hypoxia inducible factor 1 alpha in multipotent germ cells and neural stem/progenitor cells ScholarSpace (University of Hawaii at Manoa) · 2014
    8. Cepharanthine induces the proliferation of human dermal papilla cells and stimulates vascular endothelial growth factor expression through increased intracellular calcium mobilization and hypoxia‐inducible factor activation Clinical and Experimental Dermatology · 2020 · 7 citations
    9. Immunohistochemical Analysis of the Mechanistic Target of Rapamycin and Hypoxia Signalling Pathways in Basal Cell Carcinoma and Trichoepithelioma PloS one · 2014 · 15 citations
    10. Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production Journal of Medicinal Food · 2018 · 6 citations
    11. HIF-1α Stimulators Function Equally to Leading Hair Loss Agents in Enhancing Dermal Papilla Growth Skin Pharmacology and Physiology · 2020 · 6 citations
    12. FLCN regulates transferrin receptor 1 transport and iron homeostasis 2021 · 1 citations
    13. KRT17 promotes endometrial cancer cell migration as well as angiogenesis by regulating HIF-1α/VEGF pathway European journal of gynaecological oncology · 2023
    14. Spermidine/spermine-<i>N</i><sup>1</sup>-acetyltransferase: a key metabolic regulator AJP Endocrinology and Metabolism · 2008 · 305 citations
    15. Scarless wound healing: Transitioning from fetal research to regenerative healing Wiley Interdisciplinary Reviews-Developmental Biology · 2018 · 79 citations
    16. Gene therapy to enhance angiogenesis in chronic wounds Molecular Therapy — Nucleic Acids · 2022 · 36 citations
    17. Oxygen, Metabolism, and Regeneration: Lessons from Mice Trends in Molecular Medicine · 2017 · 35 citations
    18. UP-03.25 Urology · 2006
    19. Transcriptomic analysis identifies regulators of the Wnt signalling and hypoxia-inducible factor pathways as possible mediators of androgenetic alopecia British Journal of Dermatology · 2022
    20. Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia 2022 · 1 citations
    21. 321 Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia 2021 · 1 citations
    22. Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in <i>FoxD1</i>-lineage mesenchymal cells leads to congenital truncal alopecia bioRxiv (Cold Spring Harbor Laboratory) · 2021
    23. Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche Cell stem cell · 2011 · 695 citations
    24. 256 Expression patterns of the Siah genes in postnatal mouse skin Journal of Investigative Dermatology · 2017
    25. 1408 INDUCTION OF SECRETED WNT FACTOR WISP1/CCN4 BY HUMAN PROSTATE STROMAL CELLS BY MICROENVIORNMENTAL HYPOXIA The Journal of Urology · 2010
    26. Inhibition of the Hippo pathway by verteporfin reduces the proliferation and stemness of rat hair follicle neural crest stem cells under hypoxia FASEB BioAdvances · 2025
    27. Hypoxia in Cell Reprogramming and the Epigenetic Regulations Frontiers in Cell and Developmental Biology · 2021 · 36 citations
    28. Understanding human aging and the fundamental cell signaling link in age-related diseases: the middle-aging hypovascularity hypoxia hypothesis Frontiers in Aging · 2023 · 4 citations
    29. Hypoxia Treatment of Adipose Mesenchymal Stem Cells Promotes the Growth of Dermal Papilla Cells via HIF-1α and ERK1/2 Signaling Pathways International Journal of Molecular Sciences · 2023 · 1 citations
    30. Application of multi-omics techniques to androgenetic alopecia: Current status and perspectives Computational and Structural Biotechnology Journal · 2024