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    Glossary Marie Unna Hereditary Hypotrichosis

    rare genetic disorder causing sparse or absent hair growth

    Marie Unna Hereditary Hypotrichosis (MUHH) is a rare genetic disorder characterized by abnormal hair growth, leading to sparse or absent hair on the scalp and other parts of the body. It is inherited in an autosomal dominant pattern, meaning only one copy of the altered gene is necessary for the condition to manifest.

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    1. [Congenital hereditary hypotrychosis. Generalized autosomal dominant hypotrichosis with pili torti (hypotrichosis congenita hereditaria Marie Unna)]. PubMed · 1979 · 5 citations
    2. Significant Hair Regrowth With 5% Topical Minoxidil in a Child With Marie Unna Hereditary Hypotrichosis Caused by a Recurrent <i>HRURF</i> Variant Journal of Cosmetic Dermatology · 2025
    3. Clinical and molecular genetic studies in hereditary hair loss 2021
    4. Polarized microscopy in genetic hair disorders: case series 2025
    5. Recalcitrant Female Pattern Hair Loss Like Alopecia Unveils Unexpected Rare Entity Clinical Cosmetic and Investigational Dermatology · 2025
    6. Marie Unna hereditary hypotrichosis: A Turkish family with loss of eyebrows and a <i>U2HR</i> mutation American Journal of Medical Genetics - Part A · 2010 · 11 citations
    7. A distinct gene close to the hairless locus on chromosome 8p underlies hereditary Marie Unna type hypotrichosis in a German family British Journal of Dermatology · 2000 · 36 citations
    8. Clinical course of the first Japanese family with Marie Unna hereditary hypotrichosis: a follow-up report European Journal of Dermatology · 2018
    9. Marie Unna Hereditary Hypotrichosis Gene Maps to Human Chromosome 8p21 Near Hairless Journal of Investigative Dermatology · 2000 · 29 citations
    10. Marie Unna Hereditary Hypotrichosis Gene Maps to Human Chromosome 8p21 Near Hairless Journal of Investigative Dermatology · 2000 · 4 citations
    11. Marie-unna hereditary hypotrichosis International Journal of Trichology · 2014 · 4 citations
    12. Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis Nature Genetics · 2009 · 181 citations
    13. A newly identified missense mutation of the HR gene is associated with a novel, unusual phenotype of Marie Unna Hereditary Hypotrichosis 1 including limb deformities Archives of Dermatological Research · 2012 · 6 citations
    14. A novel mutation in Hr causes abnormal hair follicle morphogenesis in hairpoor mouse, an animal model for Marie Unna Hereditary Hypotrichosis Mammalian genome · 2009 · 21 citations
    15. Two females with hair loss Journal der Deutschen Dermatologischen Gesellschaft · 2019
    16. Differential diagnosis of hair loss in children. Differentialdiagnose des Haarausfalls bei Kindern Journal der Deutschen Dermatologischen Gesellschaft · 2004 · 30 citations
    17. Poly(rC) binding protein 2 acts as a negative regulator of IRES-mediated translation of Hr mRNA 2018 · 3 citations
    18. Biology and Genetics of Hair Annual Review of Genomics and Human Genetics · 2010 · 89 citations
    19. A KRT71 Loss-of-Function Variant Results in Inner Root Sheath Dysplasia and Recessive Congenital Hypotrichosis of Hereford Cattle Genes · 2021 · 2 citations
    20. The stem cell quiescence and niche signaling is disturbed in the hair follicle of the hairpoor mouse, an MUHH model mouse Stem cell research & therapy · 2022 · 2 citations
    21. Congenital hypotrichosis due to short anagen British Journal of Dermatology · 2000 · 42 citations
    22. Autosomal recessive hypotrichosis simplex with woolly hair: a report of a new family Dermatology Reports · 2011 · 1 citations
    23. Alopezien und Hypotrichosen im Kindesalter Der Hautarzt · 2014 · 5 citations
    24. A Missense Mutation within the Helix Initiation Motif of the Keratin K71 Gene Underlies Autosomal Dominant Woolly Hair/Hypotrichosis Journal of Investigative Dermatology · 2012 · 78 citations
    25. Diseases of Periocular Hair Survey of Ophthalmology · 2011 · 7 citations
    26. Hair Shaft Dysplasias International Journal of Dermatology · 1988 · 19 citations
    27. Current Genetics in Hair Diseases InTech eBooks · 2013 · 1 citations
    28. To grow or not to grow: Hair morphogenesis and human genetic hair disorders Seminars in Cell & Developmental Biology · 2013 · 43 citations
    29. <i>DSG4</i> Gene Variants as a Cause of Hypotrichosis in the Child with Severe Atopic Dermatitis: Clinical Case Вопросы современной педиатрии · 2023
    30. Secondary cicatricial and other permanent alopecias Dermatologic Therapy · 2008 · 20 citations