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    Glossary Hypospadias

    congenital condition where urethral opening is on penis underside

    Hypospadias is a congenital condition in males where the opening of the urethra is located on the underside of the penis rather than at the tip. This can affect urination and, later in life, sexual function. Treatment often involves surgical correction to reposition the urethral opening and ensure proper function.

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    Research 30 of 173

    1. Morphological Features of External Genitalia in Hypospadiac Rat Model: 3-Dimensional Analysis The Journal of Urology · 2004 · 18 citations
    2. Surgical Atlas. Primary hypospadias repair with buccal mucosa BJU international · 2006 · 17 citations
    3. Involvement of Activation of Mitogen-Activated Protein Kinase (MAPK)/Extracellular Signal-Regulated Kinase (ERK) Signaling Pathway in Proliferation of Urethral Plate Fibroblasts in Finasteride-Induced Rat Hypospadias Medical Science Monitor · 2018 · 10 citations
    4. [The establishment of hypospadias rat model and embryoteratogenic test of Atrazine]. PubMed · 2007 · 9 citations
    5. Genetic and other epidemiological risk factors of infants and children with hypospadias: a case control study African Journal of Urology · 2023 · 4 citations
    6. Retardation of Preputial Wound Healing in Rats with Hypospadias Induced by Flutamide Journal of Investigative Surgery · 2020 · 2 citations
    7. Urethral Hair Bezoar Management With Transcutaneous Neodymium-Doped Yttrium Aluminum Garnet Laser Post-hypospadias Repair: A Clinical Case Curēus · 2023 · 1 citations
    8. Re: The Efficacy of Dihydrotestosterone Transdermal Gel Before Primary Hypospadias Surgery: A Prospective, Controlled, Randomized Study The Journal of Urology · 2008 · 1 citations
    9. DNMT1 targets SRD5A2 to induce mitochondrial homeostasis and EMT in urothelial cells of hypospadias Molecular Biology Reports · 2025
    10. Case Report: Disorder of Sex Development 46, XY with Proximal Hypospadias in a 10-Year-Old Twin Boy: Disorder of Sex Development 46, XY with Proximal Hypospadias Journal of Health, Medicine and Nursing · 2020
    11. Pesticides Exposure and Risk of Hypospadias InTech eBooks · 2011
    12. A rabbit model of hypospadias induced by finasteride Zhonghua miniao waike zazhi · 2006
    13. The distribution of Preputial vessels in different severity of rat congenital hypospadias model: imaging study using micro-computerized tomography BMC urology · 2019 · 2 citations
    14. The Distribution of Preputial Vessels in Different Severity of Rat Congenital Hypospadias Model: Imaging study using Micro-Computerized Tomograph Research Square (Research Square) · 2019
    15. The Distribution of Preputial Vessels at Different Severity of Rat Congenital Hypospadias Model Research Square (Research Square) · 2019
    16. Molecular epidemiology of hypospadias: Review of genetic and environmental risk factors Birth Defects Research · 2003 · 103 citations
    17. Challenges of using tissue engineering methods in the treatment of hypospadias Frontiers in Bioengineering and Biotechnology · 2025
    18. Preoperative hormonal stimulation in hypospadias: a systematic review ˜The œAnnals of african surgery · 2023
    19. The role of pre-operative androgen stimulation in hypospadias surgery. PubMed · 2014 · 4 citations
    20. The rare association of congenital glaucoma, giant melanocytic nevus, alopecia, and hypospadias in an Egyptian child with neurofibromatosis type 1: a case report Egyptian Journal of Medical Human Genetics · 2024
    21. Finasteride Drugs · 1999 · 125 citations
    22. External genitalia abnormalities in male rats exposed in utero to finasteride, a 5α-reductase inhibitor Teratology · 1990 · 122 citations
    23. Effects of in Utero Exposure to Finasteride on Androgen-Dependent Reproductive Development in the Male Rat Toxicological Sciences · 2003 · 118 citations
    24. Critical Developmental Periods for Effects on Male Rat Genitalia Induced by Finasteride, a 5α-Reductase Inhibitor Toxicology and Applied Pharmacology · 1993 · 86 citations
    25. Effects of finasteride, a type 2 5-alpha reductase inhibitor, on fetal development in the rhesus monkey (Macaca mulatta) Teratology · 1997 · 67 citations
    26. Regulation of masculinization: androgen signalling for external genitalia development Nature Reviews Urology · 2018 · 45 citations
    27. Systematic analyses of murine masculinization processes based on genital sex differentiation parameters Development Growth & Differentiation · 2015 · 21 citations
    28. ODP398 A Novel NR5A1 Gene Mutation Causing 46, XY DSD Without Adrenal Insufficiency in an Immigrant Boy from Dominican Republic Journal of the Endocrine Society · 2022
    29. Modelling androgen synthesis and action during human sexual differentiation ePrints Soton (University of Southampton) · 2010
    30. Disorders linked to insufficient androgen action in male children 2001