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This review outlines the transition from simple hair follicle organoids to immune-competent microphysiological systems, addressing limitations in replicating native hair follicle immune features and discussing their applications in disease modeling and regenerative medicine.

This study found that incorporating dermal papillae cells and keratinocytes into dermal substitutes promoted better wound healing, reduced contraction, and enabled appendage formation in tissue-engineered skin on mice.

This special issue reviews advancements in engineering cell microenvironments for tissue engineering, highlighting various studies on interventions like silk fibroin and platelet-rich plasma, but presents no new empirical findings.

Researchers created a fully functional, bioengineered skin system with hair from stem cells that successfully integrated when transplanted into mice.

This study found that CLD-hFGF2 hydrogels improved healing in deep second-degree burn wounds more effectively than hydrogels alone or direct administration of CLD-hFGF2.

This study developed in vitro methods to regenerate hair follicles and erector muscles by mimicking their native structures and mechanical conditions, reconstructing hair follicle-like structures and forming muscle-like tissues.

This study explored the development of GelMet, an electrospun hybrid nanofiber scaffold made from gelatin and PEG methacrylate, which demonstrated strong mechanical properties and effectively supported cell growth in vitro, suggesting its potential for skin tissue engineering applications.

This study developed and tested continuous implanters for dermal papilla cell aggregates, finding that the bar-cartridge type implanter is the most effective design for continuous cell implantation in androgenetic alopecia research.

This study developed keratin-based hydrogels with improved water solubility and tunable properties, demonstrating excellent cytocompatibility, suggesting potential for biomedical applications.

In this study, forced expression of the transcription factor cDermo-1 in chicken dermis led to the formation of ectopic feather buds and enhanced feather growth, demonstrating its role in initiating skin appendage development.

This study demonstrated in rodent models that artificial dermal template treatment can induce full-thickness skin regrowth including skin epidermis and adnexa without the need for autologous skin grafts.

This study suggests that activating the hexosamine pathway may enhance skin homeostasis, potentially increasing hair follicle stem cells and modifying extracellular matrix components like hyaluronic acid in vitro.

This study found that murine epidermal stem cells implanted subcutaneously in a biodegradable carrier could survive and differentiate into structures resembling native dermis without significant rejection in recipient mice.

This study demonstrates the use of microscopy-guided laser ablation to create a highly structured 3D hydrogel-based organotypic skin model with folliculoid structures, potentially useful for studying hair follicle development or bioactive substance screening.

This chapter reviews laboratory models used for studying alopecia therapies but provides no new experimental findings.

Human hair follicles can be used to create skin-like tissue for wound healing and drug testing.

This study used 3D bioprinting to implant epidermal stem cells, skin-derived precursors, and Matrigel into mouse wounds, successfully regenerating hair follicles and skin components within four weeks, with minimal impact on stem cell viability and stemness.

This study achieved a first by successfully forming large quantities of dermal papilla spheroidal microtissues, which retained their hair induction potential, using a micropatterned culture system.

This review discusses the potential use of cultured primary fetal cells from a single organ donation to produce therapeutic products, emphasizing the need for process consistency and safety verification, but reports no clinical results.

This study demonstrated that prevascularized human skin constructs containing engineered hair follicles can successfully induce human hair growth when grafted onto mice by promoting blood supply to the grafted skin.

This review discusses recent advances in developmental tissue engineering for regenerating ectodermal appendages like teeth and glands, emphasizing biomaterial selection and cell culture strategies, but reports no new experimental results.

In this study, using stirred-suspension bioreactors to expand dermal stem cells resulted in larger numbers, but had reduced efficiency in forming hair follicle structures compared to static culture conditions.

This study found that inadequate thickness of deep dermal tissue in pigs is a key factor leading to fibrosis, with fibrosis likely serving a compensatory function for skin thickness.

This study reported that a decellularized porcine amniotic membrane hydrogel can alleviate inflammation and promote tissue repair in a UVB-induced skin inflammation model, suggesting its potential as a regenerative treatment for photodamage-associated skin injuries.

This review discusses the genetic basis of ectodermal dysplasia, highlighting that identification of gene pathologies enhances diagnosis and supports prenatal DNA testing, but it reports no new clinical results.

This protocol describes a method for regenerating hair follicles using a bioengineering technique called the Organ Germ Method, but it reports no new clinical results.

This review discusses various tissue engineering approaches for hair follicle regeneration and biomaterials used, emphasizing its potential despite current clinical challenges.

In this review, researchers summarize key factors in constructing skin organoids, including cell source and assembly methods, and emphasize advances such as air-liquid interface culture for improving tissue development, aiming to guide standardized protocols and future clinical applications.