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This review outlines the structure and functions of the skin, emphasizing its role as a physical and immune barrier, its moisture regulation, the influence of its microbiome, and the supportive functions of its layers and adnexa.

This review discusses the potential of microneedles as a pain-free drug delivery method that improves medication distribution while addressing issues associated with traditional transdermal formulations.

This discussion of age-related changes in female scalp hair follicles reports no new results, highlighting the structural transformations that may contribute to thinning hair in women as they age.

This study presents a new surgical technique that frequently results in minimal scars visible to the naked eye, marking a significant improvement over traditional methods.

This study found that hypodermic injections of human dermal papilla cells conditioned medium led to hair regrowth in women with androgenetic alopecia, with an effective rate of 83.33%.

This study found that adipokines were expressed in the epidermis, hair follicles, sebocytes, apocrine glands, and vascular endothelium of normal canine skin, but not in the dermis or hypodermis.

In this study, researchers examined the histological structure of wild boar skin from three anatomical regions and found it comprises three main layers: epidermis, dermis, and hypodermis, containing various cell types and structures such as hair follicles, sebaceous glands, and fat cells.

Male and female mice have different skin thickness, and hormones affect their skin and hair growth differently.

This article lists essential items for a junior resident's bag in dermatology, detailing their uses to enhance clinical examination skills and preparedness during residency and exams.

In this study, deleting the Igf1 receptor in specific skin cells of mice affected hair follicle cycling but not overall skin health, suggesting Igf1r's role in hair cycle regulation through Bmp-4 activation.

Canine skin has two main layers: the epidermis and dermis, with a supportive subcutis layer.

This study found that using engineered skin with PGA-collagen scaffolds, combined with hair follicle stem cells and other cell types, effectively repaired full-thickness skin defects in nude mice.

This study found that human hair follicle dermal cells, specifically dermal sheath cells, can serve as an alternative and potentially superior cell source for constructing the dermal component of bioengineered skin in both in vitro and in vivo settings.

This review highlights the need for improved methods in cosmetic safety assessment, emphasizing the potential of engineered skin tissue for more effective detection and toxicological evaluation of cosmetic products, compared to traditional methods.

This study reports that incorporating Lef-1 transfected dermal papilla cells into human skin equivalents significantly promoted hair follicle differentiation and hair fiber growth, offering a potential advancement for managing skin loss.

In this study, researchers demonstrated that using 3D spheroid formation and genetic modification significantly enhanced the hair-inducing capacity of human dermal papilla cells in engineered skin constructs.

This study introduced a bioengineering platform that creates early-stage hair peg-like structures within tissue-engineered skin substitutes by integrating human keratinocytes and dermal papilla cells with laser-micropatterned collagen scaffolds, providing a foundation for future appendage-inclusive skin regeneration efforts.

This study demonstrates that human epidermal stem cells can adapt to environmental temperature changes through mTOR signaling, and prolonged inhibition of mTORC1 supports stem cell maintenance, which may be vital for regenerative medicine.

This study developed a method to convert fibroblasts into sweat gland-like cells, suggesting potential for regenerating damaged skin and restoring sweat gland function.

This study found that incorporating hair follicle-primed spheroids into skin constructs showed potential for developing hair-bearing skin mimetics with follicle-forming abilities in vitro.

This editorial discusses advances in engineering techniques for hair follicle regeneration and highlights future potential but reports no original research findings.

This study found that inserting isolated hair follicle units into engineered dermis promoted differentiation and maturation of tissue-engineered skin, maintaining hair follicle morphology and generating skin appendages like sebaceous glands.

This study found that the DexIEME hydrogel promotes complete skin regeneration and scar attenuation in murine and porcine models, suggesting potential for treating deep dermal injuries.

This study found that carefully engineered hydrogels and asymmetric morphogen gradients facilitated the formation of anatomically relevant skin organoids from iPSC-derived EBs, improving pigmentation and hair follicle generation.

This review discusses recent advancements in engineering bioengineered skin substitutes and highlights ongoing challenges, emphasizing the need for improvements in replicating uninjured skin; it reports no new experimental results.

This study reports that a new artificial skin system using multi-layered hydrogels can promote scarless wound healing and regenerate appendages like hair follicles without cell transplantation.

This study found that applying both dehydrothermal treatment and carbodiimide crosslinking improved the mechanical properties of porcine acellular dermal matrix scaffolds without added cytotoxicity, suggesting potential applications in tissue engineering.

This study developed a rapid, cost-effective three-dimensional skin equivalent model using human dermal fibroblasts, collagen, and hair follicles, which closely resembles natural human skin and can be used for autologous transplantation.

This study introduces a new multiaxial bioreactor system that uniformly stretches tissue-engineered skin grafts and improves skin tissue maturation through enhanced cellular distribution and environmental monitoring.