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Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.

The guidelines suggest a detailed approach to diagnosing and treating lupus, with a focus on regular check-ups, personalized medicine, and a range of drug options for different cases.

Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.

The document concludes that recognizing and treating cutaneous lupus erythematosus early is crucial for managing the skin and potential systemic symptoms.

Most people with systemic lupus erythematosus have skin problems, and skin symptoms are often the first sign of the disease.

Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.

Liposomes improve drug delivery and reduce skin irritation in dermatology.

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

The paper concludes that the 1982 criteria for diagnosing systemic lupus erythematosus need updating to improve accuracy and involve dermatologists in the process.

Correct skin biopsy techniques are crucial to avoid misdiagnosis of skin diseases.

UV radiation can help sterilize wounds and promote healing but requires careful use to avoid damaging cells.

Male pattern baldness involves smaller hair follicles, larger oil glands, and other tissue changes, but not major blood supply issues.

NF-κB is crucial for zebrafish heart repair, affecting heart cell growth and repair processes.

Restoring mitochondrial function in mice reversed their skin wrinkling and hair loss.

Most dermatologic medications are safe during pregnancy and breastfeeding, but some should be avoided due to potential risks.

Pregnancy causes skin changes like darkening, hair thickening, nail changes, and increased risk of skin growths, most of which usually resolve after birth.

Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.

Different types of facial fat affect aging and treatment outcomes; more research is needed to enhance anti-aging procedures.

Some plant-based treatments can help with benign prostatic hyperplasia symptoms, but more research is needed to confirm their safety and effectiveness.

Wnt signaling may be linked to heart diseases in aging and could be a target for future treatments.

K16 can partially replace K14 but causes hair loss and skin issues.

The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.

Use "female pattern hair loss" term, assess androgen excess, treat with minoxidil and other medications if needed.

The document concludes that future heart disease research should account for sex-specific differences to improve diagnosis, treatment, and outcomes.

Disrupting Smad4 in mouse skin causes early hair follicle stem cell activity that leads to their eventual depletion.

Hair and nail changes can indicate health issues, including cancer and side effects from cancer treatments.

Low serum complement levels in SLE patients don't always match with disease flares; monitoring C3 and C4 is useful, but cell-bound complement products might better indicate disease activity.

Using steroids can increase the risk of heart problems.

Common acne treatments can cause various side effects, like skin irritation and more serious issues, but combination therapies are often more effective and better tolerated.