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This review discusses changes in keratin structure or gene expression that result in various skin disorders and reports no new clinical findings.

This study found that transfecting keratinocytes with the 1α-OHase gene enhances local production of 1α,25-dihydroxyvitamin D3, suggesting a potential new therapy for skin conditions like psoriasis without causing hypercalcemia or resistance.

In this study, Rahim et al. found that keratinocyte differentiation requires changes in polyamine ratios mediated by AMD1, suggesting that targeting polyamine availability could be useful for treating hyperproliferative skin disorders.

This research identified that the constitutive and inducible expression of the Keratin 6 gene in transgenic mice skin is controlled by multiple regulatory elements spread throughout its 5' flanking region.

This study demonstrated that a specific 9-kbp fragment of the bovine keratin 6 gene effectively directs tissue-specific and inducible expression in transgenic mice, suggesting potential applications for targeted gene therapy in hyperproliferative skin conditions.

This research discusses a zebrafish model showing that nicastrin deficiency leads to tyrosinase-dependent depigmentation and melanophore cell death, suggesting implications for studying skin depigmentation disorders.

This study showed that knocking out the Ppp2ca gene in the epidermis of mice led to significant hair loss and disrupted hair follicle morphogenesis and regeneration.

The researchers reported that stress-induced keratins in human skin are expressed at lower levels than those in healthy skin and are co-regulated with genes involved in differentiation, inflammation, and immunity, rather than replacing keratins of normal differentiation or indicating cell proliferation.

This study found that high levels of human cytokeratin 16 expression in transgenic mice lead to skin lesions and altered keratinocyte structure, suggesting potential implications for human skin disorders and wound healing.

This study suggests PPAR isotypes play distinct roles in skin, influencing epidermal barrier formation, sebocyte differentiation, and lipid production, with potential implications for treating skin disorders.

This review discusses the pathophysiology of psoriasis and available treatment options but reports no clinical trial results.

This review discusses autoimmune skin disorders, including lupus erythematosus and scleroderma, and their common treatments, reporting no new clinical results.

This review discusses the unique dermatologic needs and conditions affecting women of color, noting specific skin and hair conditions but reports no clinical results.

This review discusses the potential of targeting the endocannabinoid system for treating skin disorders and reports no new clinical results, highlighting the need for further research.

This study suggests that fish oil, specifically its components EPA and DHA, play a beneficial role in promoting skin health by supporting epidermal growth and reducing proinflammatory cytokines.

This review outlines the potential of nanoemulsion-based hydrogels (nanoemulgels) for enhanced topical and transdermal drug delivery in treating skin disorders, highlighting their ability to improve therapeutic efficacy, control drug release, and boost patient compliance.

This study highlights the role of abnormal DNA methylation in skin disorders such as atopic dermatitis and psoriasis, suggesting these epigenetic changes may serve as biomarkers and targets for potential treatments.

This review discusses the role of microRNAs in skin function and potential therapeutic applications, emphasizing their importance in wound healing and disease management, though it reports no new experimental findings.

This study found that overexpressing Dsg3 in the suprabasal epidermis of transgenic mice resulted in flaking skin and abnormal hair growth, supporting Dsg3's role in regulating epidermal differentiation.

This study found that ablating centrosomes in developing epidermis alters keratinocyte division without majorly affecting differentiation, suggesting early epidermal development is driven by high proliferation and cell delamination.

This study found that centrosome ablation in developing epidermis triggers cell surveillance pathways, resulting in thinner skin and halted hair follicle growth, while later stages of epidermal growth may operate independently of basal progenitor division orientation.

This study found that ectopic expression of Whn in transgenic mice caused impaired differentiation in epidermis and hair follicles, with hair growth defects and severe urinary tract issues leading to hydronephrosis.

This review highlights the critical role of iron in skin functions and suggests potential dermatologic therapies targeting the iron-skin axis.

This chapter discusses the skin stem cell niche as a complex ecosystem and highlights the diverse components and interactions that influence stem cell function, but it reports no new experimental results.

In this study assessing post-menopausal Asian women, distinct shifts in Malassezia species prevalence on the skin were linked to increased inflammation and impaired skin barrier function, potentially driving disorders like psoriasis and seborrheic dermatitis.

This review discusses the role of epidermal and other adult stem cells in skin repair, focusing on their potential therapeutic applications for non-healing wounds and other skin disorders, but reports no new research results.

This review integrates studies on mouse models and human clinical observations to highlight the role of immune cells in skin development and how their dysregulation leads to skin disorders, suggesting potential therapeutic pathways for skin regeneration.

This review discusses the roles and characteristics of skin stem cells, their niches, and signaling pathways in skin maintenance, aging, and cancer, highlighting their potential in therapeutic applications but presenting no new clinical findings.

This study found that deleting the miRNA processing enzymes Drosha and Dicer from mouse skin epithelial cells disrupted normal hair follicle development and maintenance, leading to follicular degradation and stem cell loss during the growth phase.

This study identified the Hairless (Hr) gene-encoded protein as a corepressor that plays a crucial role in maintaining skin and hair by regulating epithelial stem cell differentiation and gene expression via chromatin remodeling, which may impact both development and disease.