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This study found that deleting the CD98hc protein in mouse skin impairs wound healing and homeostasis, resembling aging effects, due to disrupted integrin signaling pathways.

This article reviews the role of polarity proteins in epidermal morphogenesis and homeostasis and discusses how their alteration may contribute to skin disease, but reports no new experimental findings.

In this study, the researchers observed that inducing and then withdrawing β-catenin expression in a bigenic mouse model caused reversible changes in skin morphology, indicating dependence on β-catenin signaling.

This review discusses the role of epidermal and other adult stem cells in skin repair, focusing on their potential therapeutic applications for non-healing wounds and other skin disorders, but reports no new research results.

This study identified a novel recessive mutation in mice causing lethal congenital lamellar ichthyosis, with skin and hair follicle alterations similar to human congenital ichthyoses, linked to a specific genetic defect affecting Fatp4.

This article reviews the anatomy and pathology of skin and hair to aid in diagnosing skin diseases and discusses potential therapies, without reporting new clinical results.

This study reported that wound-resident mesenchymal cells can be reprogrammed to generate epithelial tissues, aiding in the closure of large, non-healing ulcers without signs of malignant transformation.

This study found that AP-2α and AP-2β transcription factors are crucial for maintaining adult skin homeostasis, with their inactivation in keratinocytes leading to impaired differentiation, hair abnormalities, and inflammation, highlighting their key regulatory roles.

This study found that activin affects both stromal cells and keratinocytes in skin morphogenesis and repair, with dose-dependent effects on keratinocytes demonstrated through transgenic mouse models.

This study found that dysregulation of the folliculin-p0071 interaction may lead to changes in cell adhesion and signaling, contributing to conditions like emphysema and renal cell carcinoma.

This study found that overexpression of activin in transgenic mice led to enhanced granulation tissue formation after skin injury due to changes in keratinocyte proliferation and differentiation.

This review summarizes the roles of bone morphogenetic proteins in the development and regulation of normal and diseased skin, but it does not provide new clinical results.

This study reported significant upregulation and release of S100A4 in psoriatic skin, which may actively contribute to psoriasis pathogenesis.

This study found that reduced cell cohesiveness in eccrine sweat gland outgrowths contributed to delayed wound healing in elderly skin compared to younger skin.

This study found that 2MbisP increases epidermal thickening more rapidly than atRA in rhino mice, while both compounds similarly reduce utricle size.

This case report observed a dramatic improvement in a 15-year-old girl's pachyonychia congenita symptoms during chemotherapy for Ewing sarcoma, suggesting chemotherapy's potential role in managing hyperkeratotic conditions.

In this study, CTCF was found to play essential roles in epidermal differentiation and skin barrier formation, simultaneously acting as a suppressor of epithelial inflammatory responses in mouse skin.

This review discusses epidermal stem cell diversity, revealing previously unrecognized differences in stem cell populations, but reports no new experimental results; it highlights the need for further exploration of stem cell interactions and quiescence.

This study found that estrogen receptor beta, not alpha, is the main mediator of estrogen action in human skin and hair follicles, suggesting a distinct role in these tissues.

This review explores embryonic epidermal development and discusses key molecular regulators and roles of the sub-epidermal mesenchyme, but reports no new experimental results.

This case report describes a patient with untreated lepromatous leprosy developing Lucio's phenomenon, highlighting difficulties in distinguishing it from erythema nodosum leprosum with vasculonecrotic lesions.

This study found that the co-ablation of C/EBPalpha and C/EBPbeta in adult mouse skin disrupted sebocyte differentiation and epidermal homeostasis, highlighting their critical roles in these processes.

This study reports that the fatty acid composition in cell membranes of stratified squamous epithelium varies with keratinization patterns, showing a partial essential fatty acid-deficient state in cultured keratinocytes.

Deleting Rac1 in the skin depletes stem cells and damages hair follicles.

This study identifies KLK14 as a significant factor contributing to hair defects and skin inflammation in a mouse model of Netherton syndrome.

This study found that activating cannabinoid receptor 1 reduces the expression of keratins K6 and K16 in human keratinocytes, suggesting potential implications for psoriasis management.

This study reports that topical fish oil treatment in GsdmA3 Dfl/+ mice increased cellular proliferation and macrophages but did not affect COX-2 expression related to psoriasis-like skin changes.

This review summarizes existing evidence on how YAP and TAZ proteins are activated in epidermal keratinocytes and their role in coordinating with other signaling molecules to control transcription and influence epidermal cell fate, highlighting their importance beyond the Hippo pathway.

This study found that CB1 receptor activation reduced keratin K6 and K16 expression in human keratinocytes in vitro and in situ, suggesting potential relevance for both psoriasis management and wound healing.

This study found that in a mouse model, betamethasone dipropionate reduced epidermal thickness while fish oil unexpectedly increased it, validating optical coherence tomography as an effective measurement tool.