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Terazosin and finasteride effectively treat BPH, but combining them adds no extra benefit.

Hair growth is cyclic and influenced mainly by local factors.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

African spiny mice can regenerate skin, hair, and cartilage, but not muscle, and their unique abilities could be useful for regenerative medicine.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

Wnt1/βcatenin signaling is crucial for heart repair after injury.

Hair growth and pigmentation in mice involve specific stages crucial for research.

Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

Finasteride treats enlarged prostate and may help with baldness, but effects on sexual function and male fetuses are unclear.

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

Superficial granulomatous pyoderma is a unique, mild form of skin disease that often heals without strong medication and responds well to milder treatments.

Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.

Finasteride may help some male chronic pelvic pain patients, but more research needed.

Psoriasis skin changes are complex and might need several biopsies for a clear diagnosis.

Understanding the mouse hair cycle is crucial for cancer research.

Dihydrotestosterone gel improved well-being and sexual function in older men without negatively affecting prostate health.

Using platelet-rich plasma with microneedling works better for acne scars than microneedling with water.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Finasteride treats enlarged prostate, shrinks it, improves urination, but may cause sexual dysfunction and isn't for women or children.

A three-month treatment with a GnRH agonist significantly lowered androgen levels and 5α-reductase activity in men with benign prostatic hyperplasia.

Mice without the Sept4/ARTS gene heal wounds better due to more stem cells that don't die easily.

Mesenchymal stem cells show potential for skin healing and anti-aging, but more research is needed for safe use, especially regarding stem cells from induced pluripotent sources.

Imiquimod 5% cream reduced equine sarcoids in most cases.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Restoring mitochondrial function in mice reversed their skin wrinkling and hair loss.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.