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This review discusses various nanotechnology-based strategies for managing melasma and reports no new clinical results, highlighting the potential of innovative drug delivery systems in treating hyperpigmentation.

This case report suggests that identifying hyperpigmentation on the upper eyelid with specific dermoscopy patterns could help diagnose facial lichen planus pigmentosus without needing a facial biopsy.

This case report highlights an atypical presentation of vitamin B12 deficiency in a 28-year-old man with reversible symptoms including localized hand hyperpigmentation and megaloblastic anemia, resolved after B12 supplementation.

This case report details a 57-year-old woman with frontal fibrosing alopecia who developed hyperpigmentation after treatment with dutasteride and pimecrolimus, highlighting no previously reported hyperpigmentation association with this combination.

This case study describes a Doberman Pinscher with a unique alopecic variant of chronic cutaneous lupus erythematosus that progressed to systemic lupus erythematosus, highlighting a rare autoimmune alopecia form in dogs.

This article discusses contact dermatitis linked to alopecia and hyperpigmentation, but it reports no new clinical results.

A rare skin condition causes red and dark patches on the face and limbs.

This case report describes a healthy 27-year-old woman with progressive alopecia and hyperpigmentation on her forehead and frontal scalp, with limited response to triamcinolone acetonide treatment.

This article reviews the need for multicenter clinical trials to establish reference data for ultrasound screening protocols for Down syndrome and reports no new findings.

In this case study, the researchers reported a rare incidence of bilateral hyperpigmented macules on a patient's lower legs, possibly due to cyclophosphamide, suggesting that this chemotherapy drug may directly stimulate hair follicles to cause skin discoloration.

This study found that hyperpigmented skin changes resembling Schamberg’s purpura occur in areas affected by CRPS and can also appear on mirror-image locations of unaffected limbs, potentially improving with the condition's treatment.

In this case report, a 13-year-old boy was diagnosed with a rare variant of cutaneous sarcoidosis presenting as Lichen Planus Pigmentosus-like hyperpigmentation, highlighting the diagnostic challenges associated with identifying uncommon manifestations of this disease.

This review provides an analysis of topical treatments with clinically proven efficacy for managing hyperpigmentation and concludes that the most effective approach is using combined therapies that target multiple aspects of skin pigmentation physiology.

Hyperpigmentation is common in pregnancy and may not fully fade after birth; melasma, also frequent, can persist but has limited treatment options during pregnancy.

This case report describes two instances of hyper-pigmentation induced by prolonged misuse of Betnovate cream, where cessation and appropriate treatment led to significant improvement within 15 days.

This study found that pigmentation following sclerotherapy is likely caused by hemosiderin deposition from red blood cells rather than post-inflammatory hyperpigmentation, with most cases resolving spontaneously within 6–24 months.

This report describes a case in which intramuscular cyanocobalamin treatment reversed skin and nail pigmentation changes and premature gray hair caused by vitamin B12 deficiency due to pernicious anemia.

This case report describes a black HIV-2 patient who experienced reversible nail, hair, and skin hyperpigmentation linked to ritonavir-boosted indinavir therapy, which resolved after discontinuation.

This case report describes a patient with skin and nail hyperpigmentation and premature gray hair due to vitamin B12 deficiency, which were reversed after treatment with cyanocobalamin.

This study found that six sessions of a modified phenol peel effectively reduced hyperpigmentation in patients with Lichen Planus Pigmentosus, with 76% of treated individuals experiencing at least a 25% improvement, and no serious side effects reported.

In this study, whole-genome sequencing of Lanping black-boned sheep identified ERBB4 and ROR1 genes as potentially important in their distinctive hyperpigmentation, enhancing understanding of their genetic evolution from Lanping normal sheep.

This case report describes the first instance of facial and oral mucosal hyperpigmentation and acanthosis nigricans linked to testosterone therapy in a patient with idiopathic hypogonadotropic hypogonadism.

This case report highlights a rare instance of severe multi-organ involvement following a single dose of methotrexate for ectopic pregnancy, requiring intensive care but ultimately successfully treated with leucovorin and supportive care.

This study found that spanlastic gel loaded with thymoquinone and ascorbic acid improved skin deposition and tyrosinase inhibition, suggesting potential as a treatment for hyperpigmentation.

Sodium valproate can rarely cause skin darkening, which may improve after stopping the drug.

In this study, ASC-enriched autologous fat grafting was found to be more effective and satisfying than conventional fat grafting for treating facial contour deformities with hyperpigmentation.

This report highlights hyperpigmentation as an underreported side effect of topical cidofovir treatment for trichodysplasia spinulosa.

This study reported the formulation of a new cream combining niacinamide and retinol aimed at reducing hyperpigmentation and providing anti-aging and moisturizing effects. It found that the cream remained stable under various environmental conditions and did not cause skin irritation in patch tests.

This case report describes a rare instance of reversible melasma-like hyperpigmentation linked to vitamin B12 deficiency due to pernicious anemia, and explores possible mechanisms for this association.

This study found that 830 nm LED light effectively treated post-inflammatory erythema and hyperpigmentation, while both 830 nm and 590 nm LEDs prevented post-inflammatory erythema.