253 citations
,
March 2006 in “The Journal of Clinical Endocrinology and Metabolism” This review discusses the hypothesis that polycystic ovary syndrome may originate in fetal life due to prenatal androgen exposure, but reports no new clinical results.
200 citations
,
October 2009 in “European journal of endocrinology” This review discusses the multifaceted actions of metformin in polycystic ovary syndrome and reports no new clinical results; the authors emphasize metformin's potential benefits in both cardiometabolic and reproductive aspects of PCOS.
96 citations
,
February 2007 in “The Journal of Clinical Endocrinology & Metabolism” This review discusses the high prevalence of androgen excess and PCOS in women with type 1 diabetes but reports no new clinical findings; the authors highlight the underdiagnosis of hyperandrogenism in these patients.
86 citations
,
October 2017 in “Translational pediatrics” This review discusses how ophthalmic findings can reveal key endocrine disorders and reports no new clinical results, emphasizing the eye's role in diagnosing and managing systemic diseases like diabetes and Graves' ophthalmopathy.
69 citations
,
September 2006 in “Human Reproduction” This study found that CD45RO+ cells, a subtype of T lymphocytes, were notably reduced in the ovarian follicles of women with PCOS, which may contribute to the condition's pathogenesis.
60 citations
,
February 2010 in “Gynecological Endocrinology” This study suggests that adding metformin to diet and exercise improves insulin resistance and hyperandrogenism in women with PCOS, though lifestyle changes alone may enhance menstrual cycles.
43 citations
,
May 1988 in “British Journal of Dermatology” This study reported that patients with acanthosis nigricans and insulin resistance exhibited higher insulin levels and were associated with increased insulin resistance correlating with serum testosterone levels.
42 citations
,
July 2017 in “Scientific Reports” This study found that insulin resistance was significantly associated with PCOS among infertile women with central obesity, highlighting differences in insulin and phenotype severity.
40 citations
,
April 2008 in “European journal of endocrinology” In this study, treatment with insulin sensitizers significantly increased adipose tissue GLUT4 mRNA expression and improved insulin resistance, menstrual patterns, and androgen profiles in PCOS patients, with rosiglitazone being more effective than metformin.
39 citations
,
January 2012 in “Reproductive Biology and Endocrinology” In this study, the prevalence of polycystic ovary syndrome among women seeking primary healthcare in Salvador, Brazil, was found to be 8.5% using the Rotterdam criteria.
24 citations
,
July 2012 in “Current Opinion in Obstetrics & Gynecology” This review discusses the diagnostic criteria and treatment options for adolescent polycystic ovary syndrome, highlighting ongoing debates and the need for further research, without presenting new clinical results.
21 citations
,
December 2007 in “Primary Care” This article reviews the challenges in treating PCOS, noting the potential benefits of insulin sensitizers on ovulatory function and pregnancy outcomes, and calls for more long-term studies on metabolic interventions.
16 citations
,
December 2007 in “Expert Review of Pharmacoeconomics & Outcomes Research” This review discusses the impact of polycystic ovary syndrome on health-related quality of life, highlighting its negative effects which may be influenced by cultural perceptions, obesity, infertility, and menstrual issues.
14 citations
,
March 2023 in “Scientific Reports” This study found that in women with polycystic ovary syndrome, PCOS phenotype and oxidative stress markers were significantly related to free androgen index levels, but insulin resistance was not.
14 citations
,
September 2015 in “Expert Opinion on Therapeutic Targets” This review discusses potential treatments for androgen excess in polycystic ovary syndrome and reports no new findings, emphasizing the importance of individualized antiandrogenic management to minimize side effects.
14 citations
,
January 2012 in “Endocrine development” This article reviews the challenges in diagnosing mild hyperandrogenism in adolescent girls, discussing potential causes like PCOS and treatment options, but reports no new clinical results.
11 citations
,
July 2012 in “Current Opinion in Pediatrics” This review discusses dermatologic signs in childhood endocrine disorders and highlights their importance in early diagnosis and treatment, but it reports no new clinical findings.
9 citations
,
July 2009 in “Journal Of Endocrinology, Metabolism And Diabetes Of South Africa” The document concludes that managing PCOS involves treating symptoms and reducing long-term metabolic risks, with lifestyle changes being important.
4 citations
,
June 2019 in “Revista brasileira de ginecologia e obstetrícia” This article discusses the prevalence of hirsutism in women and highlights that many cases exhibit normal androgen levels, suggesting a need for broader diagnostic approaches.
3 citations
,
January 2018 in “Journal of South Asian Federation of Obstetrics and Gynaecology” This study compared letrozole and clomiphene citrate for ovulation induction in women with polycystic ovary syndrome and found that while clomiphene led to more follicles, monofollicular development and endometrial thickness were higher with letrozole, and pregnancy rates did not significantly differ between the two treatments.
2 citations
,
September 2004 in “Fertility and sterility” This review discusses the cosmetic and health implications of hirsutism and highlights its potential link to serious underlying disorders, but it presents no new clinical findings.
January 2024 in “Epidemiology international journal” This study observed a 19.7% prevalence of polycystic ovarian syndrome among Afro-Caribbean women in Tobago, a rate higher than that reported in North American studies.
March 2019 in “Journal of Investigative Dermatology” This review discusses a quiz related to seborrheic dermatitis diagnosis and key findings from a previous study, but reports no new clinical results.
January 2014 in “S. Karger AG eBooks” Type 2 diabetes in youth is increasing, with high treatment failure rates and more severe than Type 1; certain drugs can lower lipid levels effectively with varying side effects, and apples may benefit heart health like statins but with fewer side effects.
February 2012 in “InTech eBooks” This review discusses the impact of polycystic ovary syndrome on cardiovascular risk and reports no new clinical findings.
June 2008 in “CRC Press eBooks” PCOS may have evolved as an advantage in past environments with food scarcity.
2 citations
,
April 2023 in “Diabetes Metabolic Syndrome and Obesity” 2h-ICPR can help screen for insulin antibodies in type 2 diabetes patients.
2 citations
,
June 2009 in “The Nurse practitioner” This article highlights that many women with PCOS are unaware of their condition and its increased risks for type 2 diabetes and cardiovascular disease, and it offers no new clinical findings.
August 2026 in “Tropical Journal of Pharmaceutical and Life Sciences” This study highlights that insulin resistance is a key pathological feature for individuals with PCOS, particularly those with obesity, affecting the response of specialized cells and leading to increased inflammation, regardless of Body Mass Index differences within the PCOS population.
2 citations
,
December 2024 in “Sohag Medical Journal” This paper discusses insulin resistance's effects on skin physiology, emphasizes its role in keratinocyte balance, and reports no new experimental findings.