36 citations
,
November 2018 in “American Journal of Clinical Dermatology” This review discusses the significant burden of disease and psychosocial implications associated with alopecia, highlighting its comorbidities and the impact on quality of life despite being viewed traditionally as an aesthetic concern, but reports no clinical results.
35 citations
,
February 2012 in “The New England Journal of Medicine” Early diagnosis and treatment of TPP can prevent complications.
35 citations
,
August 2010 in “The American journal of pathology” This study reports that hypomorphic alleles of the Ass1 gene in mice resemble human CTLN1, providing a potential model for preclinical studies and indicating that standard treatments for CTLN1 can rescue phenotypes.
35 citations
,
June 2005 in “The Milbank Quarterly” This article describes a framework for evaluating new health technologies by integrating quantitative evidence with qualitative assessments and using precedents to guide policy decisions, without reporting new clinical results.
35 citations
,
August 2001 in “Journal of Cutaneous Medicine and Surgery” This paper reviews the use of tacrolimus for various conditions, noting its effectiveness in treating certain skin disorders but highlighting that some findings remain anecdotal due to limited case numbers.
34 citations
,
September 2020 in “BMC Endocrine Disorders” This review highlights that while dexamethasone may reduce mortality in severe COVID-19, no other drugs have proven effectiveness for treatment, emphasizing the need for clinical trials of existing medications.
34 citations
,
September 2009 in “International Journal of Dermatology” This article reviews the skin effects of anabolic-androgenic steroid use in athletes but reports no clinical results.
33 citations
,
January 2015 in “Journal of Cosmetic Dermatology” This study reports that familial frontal fibrosing alopecia was diagnosed earlier in premenopausal women compared to postmenopausal women, though long-term outcomes remain uncertain without a definitive treatment.
33 citations
,
November 2012 in “Journal of The American Academy of Dermatology” This study reported that female pattern hair loss was prevalent in 11.8% of women aged 30 and older and was associated with high fasting glucose, fewer childbirths, oral contraceptive use, and excessive ultraviolet exposure.
33 citations
,
November 2008 in “European Journal of Pharmaceutical Sciences” This study found that St. John's wort treatment for two weeks induced finasteride metabolism and reduced its plasma exposure in healthy men.
32 citations
,
January 2021 in “Molecules” This review compiles studies on the antidiabetic potential of plants from the Middle East, particularly from the Asteraceae and Lamiaceae families, but reports no clinical results.
32 citations
,
July 2018 in “Scientific Reports” In this study, the authors reported that feeding cashmere goats with essential oil-cobalt significantly enhanced their growth, meat quality, and fiber quality, while stimulating immune-related physiological changes.
31 citations
,
September 2012 in “Human Brain Mapping” In this study, patients with seasonal affective disorder were found to have increased functional connectivity in certain brain networks and higher low-frequency fluctuations compared to healthy controls, which aligns with their attentional and psychomotor symptoms.
30 citations
,
July 2018 in “Scientific Reports” In this study, a high-fat, high-cholesterol diet in atherosclerotic mice led to skin inflammation and hair problems, which could be reversed by inhibiting glycosphingolipid synthesis.
30 citations
,
March 2001 in “Environmental Health Perspectives” This review explores the significant impacts of hormonal changes within normal physiological ranges and suggests examining low-dose effects from chemicals disrupting hormonal activity; it presents no new clinical results.
29 citations
,
January 2009 in “Gynecological Endocrinology” This study found that women with polycystic ovary syndrome have significantly higher plasma levels of thrombin-activatable fibrinolysis inhibitor and other hemostatic markers compared to age- and BMI-matched healthy controls.
28 citations
,
January 2007 in “Journal of dermatology” This case report describes instances of lipedematous scalp and lipedematous alopecia in white adults, indicating these rare conditions may be more widespread and frequent in this population than previously thought.
28 citations
,
August 2000 in “Current Opinion in Chemical Biology” This article reviews current osteoporosis treatments, focusing on the potential of selective androgen receptor modulators and other agents to enhance bone formation, but provides no new clinical data.
27 citations
,
December 2020 in “Experimental Dermatology” This study reported that COVID-19 was causally associated with postinfectious hair shedding, which varied with disease severity, but hair completely recovered.
27 citations
,
June 2017 in “International Journal of Dermatology” This study found that acne keloidalis nuchae was associated with pseudofolliculitis barbae, chronic scalp folliculitis, and aspects of the metabolic syndrome, particularly hypertension, in the examined population.
26 citations
,
October 2020 in “Pediatric Dermatology” This study found that oral tofacitinib led to clinically significant improvement in alopecia areata severity scores among pre-adolescents, though results varied and further evaluation in clinical trials is needed.
26 citations
,
April 2019 in “Journal of Cosmetic Dermatology” This review discusses the potential of herbal treatments like Saw palmetto, Green tea, and Rosemary as alternatives to conventional drugs for androgenetic alopecia, noting that these herbs may inhibit the 5-alpha-reductase enzyme and reduce hair loss with fewer side effects.
26 citations
,
October 2017 in “Clinical Reviews in Allergy & Immunology” This review explores skin manifestations associated with autoimmune liver diseases and highlights known and probable links, such as vitiligo's strong association with autoimmune hepatitis.
26 citations
,
February 2002 in “Urologic clinics of North America” This review examines the placebo response in conditions such as allergies and weight loss, highlighting its significance in both conventional and alternative medicine randomized trials, without reporting any new results.
25 citations
,
July 2019 in “Experimental Dermatology” This review discusses the role of cholesterol homeostasis in hair follicle biology and its potential connections to various hair disorders, but it reports no new findings.
25 citations
,
April 2018 in “Journal of Cosmetic Dermatology” This study found that platelet-rich plasma injections improved hair density and diameter in women with androgenetic alopecia not responding to other treatments over 24 weeks, with no adverse events reported.
25 citations
,
October 2015 in “Dermatology” This study observed that dapsone may be effective for treating pustular psoriasis, as four out of five patients showed improvement after previously failing other treatments.
25 citations
,
September 2014 in “Dermatologic Surgery” This study found that hair transplantation using round grafts improved hair growth in African American women with end-stage CCCA, showing no postoperative scarring in the donor or recipient areas.
25 citations
,
July 2013 in “Actas Dermo-Sifiliográficas” This review discusses consensus guidelines for the use of acitretin in psoriasis, highlighting its ongoing utility in both mono and combination therapies, despite not always being recognized in treatment guidelines.
24 citations
,
November 2023 in “NEWPORT INTERNATIONAL JOURNAL OF SCIENTIFIC AND EXPERIMENTAL SCIENCES” This article reviews the various short- and long-term side effects of antiretroviral therapy for HIV, highlighting issues like dyslipidemia and hypertension, but reports no new clinical results.